Age Prevalence of Antibody to Human Herpesvirus 6

Briggs, Moya; Fox, Julie D.; Tedder, Richard S.

doi:10.1016/s0140-6736(88)91883-1

Cited by 160 publications

(85 citation statements)

References 3 publications

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“…Initial studies suggested a low prevalence of antibody to HHV-6 in the general population (l), although it now appears that it is a relatively common viral infection, with 52% of the UK population (3) and 72% of the US population (4) being reported as seropositive. Antibody prevalence studies suggest that infection occurs very early in life (4), with a consistent decline in antibody levels with age (43).…”

Section: To the Editormentioning

confidence: 99%

Antibodies to human herpesvirus‐6 in Sjögren's syndrome

Baboonian

Venables

Maini

et al. 1990

Arthritis & Rheumatism

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Section: To the Editormentioning

confidence: 99%

Antibodies to human herpesvirus‐6 in Sjögren's syndrome

Baboonian

Venables

Maini

et al. 1990

Arthritis & Rheumatism

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“…Sera positive by immunofluorescence were scored +, + +, or + + + depending on the intensity of the fluorescent staining as previously described [9]. On evaluating the test it was found that the titre by end-point dilution closely correlated with the score given at a fixed dilution.…”

Section: Introductionmentioning

confidence: 99%

“…Initial serological studies using an indirect immunofluorescence (IF) test to detect antibody to our strain (AJ) of HHV6 showed that 52 % of healthy adults were seropositive for anti-HHV6 IgG and that infection with the virus occurred very early in life [9]. To assess any serological cross-reaction between HHV6 and other human herpesviruses we examined sera from 96 infected with the AJ strain of HHV6 were placed on multispot slides, air-dried and fixed with acetone.…”

Section: Introductionmentioning

confidence: 99%

Production of IgM antibody to HHV6 in reactivation and primary infection

Fox¹,

Ward²,

Briggs³

et al. 1990

Epidemiol. Infect.

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SUMMARYThe cross-reaction of HHV6 antibody with that to the other herpesviruses was studied in 96 blood donors whose sera were tested for IgG antibody to human herpesvirus type 6 (HHV6), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zostervirus (VZV) and herpes simplex virus (HSV). No correlation was found between IgG antibody to HHV6 and that to any of the other herpesviruses in these individuals. Antibodies to HHV6 and CMV were measured in patients undergoing documented serological responses to HHV6. Eleven cases of primary HHV6 infection associated with roseola infantum in babies, 1 of whom suffered from gastroenteritis as well as pyrexia and rash, are reported. Three cases of HHV6 reactivation, 1 in a 3-year-old child and 2 in adults, 1 of whom simultaneously underwent a primary CMV infection are also reported. Our results suggest that indirect immunofluorescence is a specific way of measuring HHV6 antibody, that HHV6 IgG and IgM can be detected in the absence of antibody to CMV and that HHV6 IgM is present both in primary HHV6 infections and in reactivations.

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“…A possible site of latent virus DNA has been identified in monocytes or macrophages (Kondo et al, 1991) and initial infection may occur through epithelial cells in salivary glands which can harbour the virus (Fox et al, 1990;Levy et al, 1990a). Primary infection is inapparent or causes a mild skin rash in infants, 'exanthem subitum' (Yamanishi et al, 1988;Dewhurst et al, 1992); seroconversion (60 % to 90% of 0001-1373 © 1993 SGM the population) occurs usually before 1 year of age (Briggs et al, 1988;Okuno et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients

Gompels

Carrigan

Carss

et al. 1993

Journal of General Virology

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Fifteen human herpesvirus 6 (HHV-6) strain variants were analysed by PCR amplifications, restriction enzyme site polymorphism and sequence analyses. Three DNA regions were chosen for study: a fragment of a variable glycoprotein gene (210 bp), the conserved glycoprotein H (gH) gene complete with intergenic sequences (2381 bp) and the 5' intergenic region with the Nterminal coding sequence of gH up to a polymorphic BamHI site (427 bp). Infected cell DNA from five laboratory reference strains including GS, Ul102, AJ, Z29 and KF were examined together with DNA from peripheral blood lymphocytes infected with HHV-6 reactivated from blood and/or marrow from five bone marrow transplant (BMT) patients. Separate blood and marrow isolates were obtained from four BMT patients. In addition, HHV-6 sequences were examined directly from one of six Hodgkin's lymphomas and six B cell proliferations which contained HHV-6 DNA as detected by PCR amplification. The results show two groups of very closely related but heterogeneous strains which correlate with previous groupings by antigenic and restriction site differences. These are variant A strains (including laboratory strains GS, Ul102 and AJ) and variant B strains (including laboratory strains Z29 and KF, the Hodgkin's lymphoma strain, and the nine BMT patient isolates). Variations between the groups were 4 to 6 % in nucleotide sequence and 5 to 8.5 % in amino acid sequence. Within each group maximum heterogeneity was observed in different genes. Variant A strains differed by 2-0% in the variable glycoprotein gene sequence whereas variant B strains were identical in this region; conversely, variant B strains differed by 2 to 3 % in the gH N-terminal and intergenic sequences whereas variant A strains differed there by less than 0'2%. There was evidence for sequence drift independent of selection: relationships between the groups were shown by analyses of amino acid sequence, coding nucleotide sequence as well as intergenic sequence, and the B variant-specific BamHI site in the gH gene was due to a non-coding nucleotide substitution. There was little evidence for in vivo or in vitro variation: the gH nucleotide sequence from the uncultured lymphoma strain (first variant B gH gene identified) was almost identical to the gH sequence from four BMT isolates, and matched BMT isolates from blood and marrow were identical or with a single nucleotide substitution. The overall variation observed between the HHV-6 strain groups was similar or less than that seen between human cytomegalovirus strains such as AD169 or Towne, but deafly distinct from the much greater divergence between currently designated herpesvirus species.

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Age Prevalence of Antibody to Human Herpesvirus 6

Cited by 160 publications

References 3 publications

Antibodies to human herpesvirus‐6 in Sjögren's syndrome

Antibodies to human herpesvirus‐6 in Sjögren's syndrome

Production of IgM antibody to HHV6 in reactivation and primary infection

Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients

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