Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin

Heredia, Fátima Pérez de; Larqué, Elvira; Portillo, María del Puy; Canteras, Manuel; Zamora, Salvador; Garaulet, Marta

doi:10.1016/j.nut.2008.03.022

Cited by 23 publications

(16 citation statements)

References 42 publications

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“…Adipose tissue shows a decrease of saturates and increase of monounsaturates with aging [54], and a similar age-related increase in monounsaturated FAs has been also reported in liver [55]. These reports are consistent with our observations that monounsaturates concentration was found to be higher in aged rats and that both groups followed similar pattern, thus confirming that this is probably an age-related effect.…”

Section: Discussionsupporting

confidence: 92%

High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

et al. 2009

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Section: Discussionsupporting

confidence: 92%

High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

et al. 2009

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“…The higher adiposity in HF males could be related to their low energy expenditure and whole body oxygen consumption, which we have previously described in the same experimental model [37]. In addition, only male rats show a significant negative correlation between adipose PUFA content and adiposity index in both adipose tissues, which suggests the existence of sex differences in the adipogenic effect of PUFA depending on their dietary content [38]. In this sense, we also found a positive correlation between PUFA intake and adiposity index for male rats (r = 0.881, p < 0.05) but not for females.…”

Section: Discussionmentioning

confidence: 71%

Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats

et al. 2011

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BackgroundHigh-fat (HF) diet feeding usually leads to hyperphagia and body weight gain, but macronutrient proportions in the diet can modulate energy intake and fat deposition. The mechanisms of fat accumulation and mobilization may differ significantly between depots, and gender can also influence these differences.AimTo investigate, in rats of both sexes, the effect of an isocaloric intake of a diet with an unbalanced proportion of macronutrients on fatty acid composition of visceral and subcutaneous adipose tissues and how this is influenced by both dietary fatty acids and levels of proteins involved in tissue lipid handling.MethodsEight-week-old Wistar rats of both sexes were fed a control diet (3% w/w fat) or high-fat diet (30% w/w fat) for 14 weeks. Fatty acid composition was analyzed by gas-chromatography and levels of LPL, HSL, α2-AR, β3-AR, PKA and CPT1 were determined by Western blot.ResultsThe HF diet did not induce hyperphagia or body weight gain, but promoted an increase of adiposity index only in male rats. HF diet produced an increase of the proportion of MUFA and a decrease in that of PUFA in both adipose depots and in both sexes. The levels of proteins involved in the adrenergic control of the lipolytic pathway increased in the gonadal fat of HF females, whereas LPL levels increased in the inguinal fat of HF males and decreased in that of females.ConclusionSexual dimorphism in adiposity index reflects a differential sex response to dietary fatty acid content and could be related to the levels of the proteins involved in tissue lipid management.

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“…In our experimental model, despite the similar gains in body density and intra-abdominal fat mass, the 19S group showed an increase in the size and a decrease in the number of retroperitoneal adipocytes compared to the 19C group. Other authors studying models of obesity induced by a high-fat diet intake have observed that the development of body fat compartments and the adipocyte fatty acid composition are affected by the type of fat contained in the diet 36-39. When a high-fat diet containing omega-6 is consumed, peroxisome proliferator-activated receptor gamma (PPARγ) helps to convert unspecialized cells into adipocytes to store extra fat 40.…”

Section: Discussionmentioning

confidence: 99%

Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil

Costa

Carlos²,

Santos³

et al. 2011

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OBJECTIVES:A low ratio of omega-6/omega-3 polyunsaturated fatty acids is associated with healthy bone properties. However, fatty diets can induce obesity. Our objective was to evaluate intra-abdominal adiposity, insulin, and bone growth in rats fed a high-fat diet containing low ratios of omega-6/omega-3 provided in canola oil.METHODS:After weaning, rats were grouped and fed either a control diet (7S), a high-fat diet containing soybean oil (19S) or a high-fat diet of canola oil (19C) until they were 60 days old. Differences were considered to be significant if p<0.05.RESULTS:After 60 days, the 19S and 19C groups showed more energy intake, body density growth and intra-abdominal fat mass. However, the 19S group had a higher area (200%) and a lower number (44%) of adipocytes, while the 7S and 19C groups did not differ. The serum concentrations of glucose and insulin and the insulin resistance index were significantly increased in the 19C group (15%, 56%, and 78%, respectively) compared to the 7S group. Bone measurements of the 19S and 19C groups showed a higher femur mass (25%) and a higher lumbar vertebrae mass (11%) and length (5%). Computed tomography analysis revealed more radiodensity in the proximal femoral epiphysis and lumbar vertebrae of 19C group compared to the 7S and 19S groups.CONCLUSIONS:Our results suggest that the amount and source of fat used in the diet after weaning increase body growth and fat depots and affect insulin resistance and, consequently, bone health.

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Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin

Cited by 23 publications

References 42 publications

High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats

Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil

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