Age-related changes in regional cerebral blood flow among young to midlife adults

Schultz, Susan K.; O'Leary, Daniel S.; Ponto, Laura L. Boles; Watkins, G. Leonard; Hichwa, Richard D.; Andreasen, N.C.

doi:10.1097/00001756-199908200-00011

Cited by 101 publications

(58 citation statements)

References 2 publications

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“…Age-associated reduction in blood flow is well documented (Iwata and Harano, 1986; Schultz et al, 1999; Takahashi et al, 2005). However, the correlation between age and cerebral hypoperfusion is stronger in individuals with vascular risk factors (de la Torre, 2012; Fazekas et al, 1988; Kawamura et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

et al. 2014

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One of the cellular markers of neuroinflammation is increased microglia activation, characterized by overexpression of mitochondrial 18 kDa Translocator Protein (TSPO). TSPO expression can be quantified in-vivo using the positron emission tomography (PET) radioligand [18F]-FEPPA. This study examined microglial activation as measured with [18F]-FEPPA PET across the adult lifespan in a group of healthy volunteers. We performed genotyping for the rs6971 TS.PO gene polymorphism to control for the known variability in binding affinity. Thirty-three healthy volunteers (age range: 19–82 years; 22 high affinity binders (HAB), 11 mixed affinity binders (MAB)) underwent [18F]-FEPPA PET scans, acquired on the High Resolution Research Tomograph (HRRT) and analyzed using a 2-tissue compartment model. Regression analyses were performed to examine the effect of age adjusting for genetic status on [18F]-FEPPA total distribution volumes (VT) in the hippocampus, temporal, and prefrontal cortex. We found no significant effect of age on [18F]-FEPPA VT (F (1,30) = 0.918; p = 0.346), and a significant effect of genetic polymorphism (F (1,30) = 8.767; p = 0.006). This is the first in-vivo study to evaluate age-related changes in TSPO binding, using the new generation TSPO radioligands. Increased neuroinflammation, as measured with [18F]-FEPPA PET was not associated with normal aging, suggesting that healthy elderly individuals may serve as useful benchmark against patients with neurodegenerative disorders where neuroinflammation may be present.

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Section: Discussionmentioning

confidence: 99%

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

et al. 2014

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“…20 Resolution was reduced from a voxel size of 1.08 mm‫ן‬ ‫84.1ן53.1‬ to 3.0 mm‫7.2ן‬ mm‫2ן‬ mm to decrease the time required to compute the large number of correlations. In assessing the correlation matrix, the probability levels were adjusted to reflect the number of independent resolution elements or "resels."…”

Section: Regional Blood Flow Analysismentioning

confidence: 99%

Cerebral Blood Flow Changes Associated With Schneiderian First-Rank Symptoms in Schizophrenia

Franck

O'Leary²,

Flaum³

et al. 2002

JNP

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The authors examined the severity of Schneiderian first-rank symptoms in relation to regional cerebral blood flow (rCBF) with the use of PET. Eighty-seven schizophrenic patients were imaged during an eyes-closed condition during which they were instructed to relax and not perform any specific task (random episodic silent thought, or REST). Schneiderian symptoms were rated by using structured assessment instruments. The Schneiderian score of the patients was positively correlated with rCBF in right superior parietal cortex and negatively correlated with rCBF in left posterior cingulate gyrus and in left lingual gyrus. The results of this study demonstrate a cerebral pattern of activation related to Schneiderian symptoms and reinforce the hypothesis of an involvement of cortical areas that mediate space and body representation in such phenomena.

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“…In the brain, the number of endothelial cells is very similar to that of neurons (GarciaAmado and Prensa 2012) and nearly every neuron is supplied by its own capillary, with an average distance of 8-20 μm between the neuron and the microvessels. Importantly, there is strong evidence that aging is associated with a decline in cerebral capillary density ("microvascular rarefaction") and that decreases in cerebromicrovascular density contribute to the agerelated decline in regional cerebral blood flow (Mitschelen et al 2009;Riddle et al 2003;Khan et al 2001;Lynch et al 1999;Sonntag et al 1997;Martin et al 1991;Moeller et al 1996;Farkas and Luiten 2001;Kawamura et al 1993;Krejza et al 1999;Schultz et al 1999;Bentourkia et al 2000;Hagstadius and Risberg 1989;Pagani et al 2002). The resulting mismatch between energy supply and demand has been causally linked to significant cognitive impairment (reviewed in Sonntag et al 1997;Ingraham et al 2008;Sonntag et al 2000;Warrington et al 2011;Warrington et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini

Tucsek

Valcarcel‐Ares

et al. 2016

AGE

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Strong epidemiological and experimental evidence indicate that both age and hypertension lead to significant functional and structural impairment of the cerebral microcirculation, predisposing to the development of vascular cognitive impairment (VCI) and Alzheimer's disease. Preclinical studies establish a causal link between cognitive decline and microvascular rarefaction in the hippocampus, an area of brain important for learning and memory. Age-related decline in circulating IGF-1 levels results in functional impairment of the cerebral microvessels; however, the mechanistic role of IGF-1 deficiency in impaired hippocampal microvascularization remains elusive. The present study was designed to characterize the additive/synergistic effects of IGF-1 deficiency and hypertension on microvascular density and expression of genes involved in angiogenesis and microvascular AGE (2016) 38:273-289

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Age-related changes in regional cerebral blood flow among young to midlife adults

Cited by 101 publications

References 2 publications

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

Cerebral Blood Flow Changes Associated With Schneiderian First-Rank Symptoms in Schizophrenia

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

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