Age‐Related Changes in Resting‐State Networks of A Large Sample Size of Healthy Elderly

Huang, Chun; Hsieh, Wen Jin; Lee, Pei-Lin; Peng, Li Ning; Liu, Li Kuo; Lee, Wei Ju; Huang, Jon Kway; Chen, Liang Kung; Lin, Ching Po

doi:10.1111/cns.12396

Cited by 89 publications

(74 citation statements)

References 62 publications

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“…However, in line with previous findings of greater resting-state functional connectivity in young men than women (Gur et al, 1995), and in young compared to older adults (Huang et al, 2015), young men in our study had the highest resting-state functional connectivity in the placebo condition, compared with the other age-by-sex groups. Thus, functional connectedness at rest in young men was already at a high level under placebo, and oxytocin administration in this group did not result in further increase in amygdala mPFC connectedness.…”

Section: Discussionsupporting

confidence: 93%

“…In accord with some previous work, we found trendwise enhanced amygdala mPFC resting-state functional connectivity for young compared to older adults (Huang et al, 2015), which may be affected by both reduced integrity of white matter tracts as well as neurotransmitter changes with age. We also found significantly greater amygdala mPFC resting-state functional coupling for men compared to women (Gur et al, 1995).…”

Section: Discussionsupporting

confidence: 92%

“…There is evidence of age (Huang et al, 2015) and sex (Gur et al, 1995) effects on resting-state functional connectivity. Going beyond previous work, the aim of the present study was to determine effects of intranasal oxytocin administration on resting-state functional connectivity between amygdala and mPFC, as two central regions involved in social cognition and affective processing, in an age- and sex-heterogeneous sample.…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin’s effect on resting-state functional connectivity varies by age and sex

Ebner

Chen

Porges

et al. 2016

Psychoneuroendocrinology

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The neuropeptide oxytocin plays a role in social cognition and affective processing. The neural processes underlying these effects are not well understood. Modulation of connectivity strength between subcortical and cortical regions has been suggested as one possible mechanism. The current study investigated effects of intranasal oxytocin administration on resting-state functional connectivity between amygdala and medial prefrontal cortex (mPFC), as two central regions involved in social-cognitive and affective processing. Going beyond previous work that largely examined young male participants, our study comprised young and older men and women to identify age and sex variations in oxytocin's central processes. This approach was based on known hormonal differences among these groups and emerging evidence of sex differences in oxytocin's effects on amygdala reactivity and age-by-sex-modulated effects of oxytocin in affective processing. In a double-blind design, 79 participants were randomly assigned to self-administer either intranasal oxytocin or placebo before undergoing resting-state functional magnetic resonance imaging. Using a targeted region-to-region approach, resting-state functional connectivity strength between bilateral amygdala and mPFC was examined. Participants in the oxytocin compared to the placebo group and men compared to women had overall greater amygdala mPFC connectivity strength at rest. These main effects were qualified by a significant three-way interaction: while oxytocin compared to placebo administration increased resting-state amygdala mPFC connectivity for young women, oxytocin did not significantly modulate connectivity in the other age-by-sex subgroups. This study provides novel evidence of age-by-sex differences in how oxytocin modulates resting-state brain connectivity, furthering our understanding of how oxytocin affects brain networks at rest.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxytocin’s effect on resting-state functional connectivity varies by age and sex

Ebner

Chen

Porges

et al. 2016

Psychoneuroendocrinology

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“…Our subjects are older than those in Gordon and colleagues' article, and we may assume that our subjects are also older than the overall cohort in Smith and colleagues' article. A recent article by Huang et al (2015) found that five resting state networks showed an age-related decline in functional connectivity in a study of 430 older adults, while a study by Betzel et al (2014) demonstrated age-related changes in functional connectivity both between and within resting state networks. The impact of age on resting state functional connectivity should therefore be noted while interpreting our results in conjunction with other studies.…”

Section: Resting State Network Involved In Executive Function 371mentioning

confidence: 99%

Identification of Resting State Networks Involved in Executive Function

et al. 2016

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The structural networks in the human brain are consistent across subjects, and this is reflected also in that functional networks across subjects are relatively consistent. These findings are not only present during performance of a goal oriented task but there are also consistent functional networks during resting state. It suggests that goal oriented activation patterns may be a function of component networks identified using resting state. The current study examines the relationship between resting state networks measured and patterns of neural activation elicited during a Stroop task. The association between the Stroop-activated networks and the resting state networks was quantified using spatial linear regression. In addition, we investigated if the degree of spatial association of resting state networks with the Stroop task may predict performance on the Stroop task. The results of this investigation demonstrated that the Stroop activated network can be decomposed into a number of resting state networks, which were primarily associated with attention, executive function, visual perception, and the default mode network. The close spatial correspondence between the functional organization of the resting brain and task-evoked patterns supports the relevance of resting state networks in cognitive function.

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“…The central trend regarding age-induced alterations in resting-state FC is a widespread reduction throughout the brain during the lifespan that has been more commonly reported after 60 years of age for the DMN (Damoiseaux et al 2008; Mowinckel et al 2012; Huang et al 2015; Marstaller et al 2015). Additionally, task-induced deactivation studies have also reported impaired DMN deactivation in older adults (Grady et al 2006; Harrison et al 2011; Hafkemeijer et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The association between stress and mood across the adult lifespan on default mode network

et al. 2016

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Aging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the structure and function of the default mode network (DMN), both during rest and task-induced deactivation, throughout the adult lifespan. Data confirmed a decreased functional connectivity (FC) and task-induced deactivation of the DMN during the aging process and in subjects with lower mood; on the contrary, an increased FC was observed in subjects with higher perceived stress. Surprisingly, the association of aging with DMN was altered by stress and mood in specific regions. An increased difficulty to deactivate the DMN was noted in older participants with lower mood, contrasting with an increased deactivation in individuals presenting high stress, independently of their mood levels, with aging. Interestingly, this constant interaction across aging was globally most significant in the combination of high stress levels with a more depressed mood state, both during resting state and task-induced deactivations. The present results contribute to characterize the spectrum of FC and deactivation patterns of the DMN, highlighting the crucial association of stress and mood levels, during the adult aging process. These combinatorial approaches may help to understand the heterogeneity of the aging process in brain structure and function and several states that may lead to neuropsychiatric disorders.

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Age‐Related Changes in Resting‐State Networks of A Large Sample Size of Healthy Elderly

Cited by 89 publications

References 62 publications

Oxytocin’s effect on resting-state functional connectivity varies by age and sex

Oxytocin’s effect on resting-state functional connectivity varies by age and sex

Identification of Resting State Networks Involved in Executive Function

The association between stress and mood across the adult lifespan on default mode network

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