Age-related changes in the expression of NMDA, serotonin, and GAD in the central auditory system of the rat

Shim, Hyun Joon; Lee, Lae Hyung; Huh, Youngbuhm; Lee, So Yoon

doi:10.3109/00016489.2011.622785

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…This reduction in NMDA receptors (NMDARs) expression may be involved in the change of synaptic plasticity driven by the age-related decease in sensory input, resulting in age-related impairment in the function of the NMDAR/NO signaling pathway in the CNS [44]. However, in our study, the expression of NMDARs was increased in the CN, MGB, and AC during aging, although it was found that the expression of NMDARs was decreased in the superior olivary nucleus and IC [45]. Thus, these findings also indicated that age-related changes in the NMDARs in the central auditory system were region-specific.…”

Section: Regional Changes In Nadph-d In the Aging Brainmentioning

confidence: 56%

Alterations in Nitric Oxide Synthase in the Aged CNS

Jung

Huh

2012

Oxidative Medicine and Cellular Longevity

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Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric oxide (NO) production contributes to the aging process. However, it is still unclear how NO plays a role in the aging process. This paper describes age-related changes in the activity of NADPH-diaphorase (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS), in many CNS regions. Understanding these changes may provide a novel perspective in identifying the aging mechanism.

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Section: Regional Changes In Nadph-d In the Aging Brainmentioning

confidence: 56%

Alterations in Nitric Oxide Synthase in the Aged CNS

Jung

Huh

2012

Oxidative Medicine and Cellular Longevity

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“…Age influences both the density of serotonergic fibers and acute changes in serotonin, such that both fiber density and serotonin release during social encounters decline over young adulthood in mice (Hall et al, 2011; Papesh and Hurley, 2012). In older animals, serotonin content may rise again in the IC or other auditory regions (Cransac et al, 1996; Shim et al, 2012). Reproductive readiness, via gonadal hormones, also increases serotonergic fiber density in the avian auditory midbrain (Matragrano et al, 2012).…”

Section: Serotonin-auditory Plasticity; a Channel For Past Experiencementioning

confidence: 99%

From behavioral context to receptors: serotonergic modulatory pathways in the IC

Hurley¹,

Sullivan²

2012

Front. Neural Circuits

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In addition to ascending, descending, and lateral auditory projections, inputs extrinsic to the auditory system also influence neural processing in the inferior colliculus (IC). These types of inputs often have an important role in signaling salient factors such as behavioral context or internal state. One route for such extrinsic information is through centralized neuromodulatory networks like the serotonergic system. Serotonergic inputs to the IC originate from centralized raphe nuclei, release serotonin in the IC, and activate serotonin receptors expressed by auditory neurons. Different types of serotonin receptors act as parallel pathways regulating specific features of circuitry within the IC. This results from variation in subcellular localizations and effector pathways of different receptors, which consequently influence auditory responses in distinct ways. Serotonin receptors may regulate GABAergic inhibition, influence response gain, alter spike timing, or have effects that are dependent on the level of activity. Serotonin receptor types additionally interact in nonadditive ways to produce distinct combinatorial effects. This array of effects of serotonin is likely to depend on behavioral context, since the levels of serotonin in the IC transiently increase during behavioral events including stressful situations and social interaction. These studies support a broad model of serotonin receptors as a link between behavioral context and reconfiguration of circuitry in the IC, and the resulting possibility that plasticity at the level of specific receptor types could alter the relationship between context and circuit function.

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“…Dynamic shifts in postsynaptic receptor expression accompany normal auditory learning (Sun et al 2005;Cai et al 2010) and development (Caicedo and Eybalin 1999;Kotak et al 1998;Sanes and Kotak, 2011). Agerelated hearing loss is accompanied by changes in GABA receptor distributions across the IC and ACtx (Gutiérrez et al, 1994;Milbrandt et al, 1994Milbrandt et al, , 1997Raza et al, 1994;Caspary et al, 1995Caspary et al, , 2013Yu et al, 2006), alongside changes in NMDA receptor distributions (Shim et al, 2012). Further, acute cochlear trauma leads to altered distributions of excitatory and inhibitory postsynaptic receptors in the brainstem (Suneja et al, 2000;Dong et al, 2009Dong et al, , 2010a, IC (Holt et al, 2005;Dong et al, 2010b), and ACtx (Wang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Transcriptional Changes in AMPA and GABAA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss

2019

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Debilitating perceptual disorders including tinnitus, hyperacusis, phantom limb pain and visual release hallucinations may reflect aberrant patterns of neural activity in central sensory pathways following a loss of peripheral sensory input. Here, we explore short- and long-term changes in gene expression that may contribute to hyperexcitability following a sudden, profound loss of auditory input from one ear. We used fluorescence in situ hybridization to quantify mRNA levels for genes encoding AMPA and GABA receptor subunits (Gria2 and Gabra1, respectively) in single neurons from the inferior colliculus (IC) and auditory cortex (ACtx). Thirty days after unilateral hearing loss, Gria2 levels were significantly increased while Gabra1 levels were significantly decreased. Transcriptional rebalancing was more pronounced in ACtx than IC and bore no obvious relationship to the degree of hearing loss. By contrast to the opposing, synergistic shifts in Gria2 and Gabra1 observed 30 days after hearing loss, we found that transcription levels for both genes were equivalently reduced after 5 days of hearing loss, producing no net change in the excitatory/inhibitory transcriptional balance. Opposing transcriptional shifts in AMPA and GABA receptor genes that emerge several weeks after a peripheral insult could promote both sensitization and disinhibition to support a homeostatic recovery of neural activity following auditory deprivation. Imprecise transcriptional changes could also drive the system toward perceptual hypersensitivity, degraded temporal processing and the irrepressible perception of non-existent environmental stimuli, a trio of perceptual impairments that often accompany chronic sensory deprivation.

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Age-related changes in the expression of NMDA, serotonin, and GAD in the central auditory system of the rat

Cited by 10 publications

References 20 publications

Alterations in Nitric Oxide Synthase in the Aged CNS

Alterations in Nitric Oxide Synthase in the Aged CNS

From behavioral context to receptors: serotonergic modulatory pathways in the IC

Synergistic Transcriptional Changes in AMPA and GABAA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss

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