Age-related deficit in behavioural extinction is counteracted by long-term ethanol consumption: Correlation between 5-HIAA/5HT ratio in dorsal raphe nucleus and cognitive parameters

Oliveira-Silva, Ieda F.; Pinto, Lucas; Pereira, Simone Cardoso Lisboa; Ferraz, Vany; Barbosa, Alfredo José Afonso; Coelho, Vívian Andrade Araújo; Gualberto, Felipe F.A.S.; Souza, V. F. A. de; Faleiro, Rosiane R.M.; Franco, G. A. P.; Ribeiro, Ângela Maria

doi:10.1016/j.bbr.2007.03.012

Cited by 22 publications

(19 citation statements)

References 84 publications

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“…The results of the acquisition task are similar to those previously obtained by our group (Oliveira-Silva et al 2007), except that in these earlier reported results, middle-aged rats have shown worse memory performance during the probe trial and a lower EI. All serotonergic parameters assessed were not changed by ageing in any of the studied brain area (neocortex, hippocampus, thalamus and amygdala), also not in accordance with the results reported by Oliveira-Silva et al (2007), who found an ageing effect on hippocampal 5-HIAA level. One possible explanation for these inconsistencies is the differences in experimental design.…”

Section: Discussionsupporting

confidence: 90%

“…However, one could argue that compared to the ETM, the aversive motivation in the MWM is stronger, given that the animal has to swim to stay alive. Another argument against the first hypothesis is that in a previous study carried out in the same laboratory, comparison between adult and middle-aged groups showed no significant differences in rota-rod performance (Oliveira-Silva et al 2007). However, considering that rota-rod performance depends on motor coordination and equilibrium, dysfunction of other motor functions cannot be discarded.…”

Section: Discussionmentioning

confidence: 93%

“…In addition, an age-dependent decrease in serotonin metabolite (5-HIAA) levels was observed in the hippocampus and dorsal raphe nucleus of these animals (Oliveira-Silva et al 2007). The behavioural test used to assess the spatial cognitive aspects in that study and in many others (Li et al 2009;Nakajima et al 2009;Topic et al 2005) was the Morris water maze (MWM), which is a task that can be considered aversive.…”

mentioning

confidence: 94%

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Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze

Oliveira

Graeff²,

Pereira

et al. 2010

AGE

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Emotion and spatial cognitive aspects were assessed in adult and middle-aged rats using the elevated T-maze (ETM) and the Morris water maze (MWM) tasks. Both adult and middle-aged rats were able to acquire inhibitory avoidance behaviour, though the middle-aged subjects showed larger latencies along the trials, including the baseline, which was significantly longer than that showed by adult rats. Further, compared to adult rats, middle-aged rats had longer escape latency. In spite of the worse performance in the second session of the spatial cognitive task, the middle-aged rats were able to learn the task and remember the information along the whole probe trial test. Both thalamic serotonin (5-HT) concentration and amygdala serotonergic activity (5-HIAA/5-HT) are significantly correlated, respectively, to escape latency and behavioural extinction in the MWM only for middle-aged rats. A significant correlation between the 5-HIAA/5-HT ratio in the amygdala and behavioural extinction for middle-aged, but not for adult, rats was observed. This result suggests that serotonergic activity in the amygdala may regulate behavioural flexibility in aged animals. In addition, a significant negative correlation was found between hippocampal 5-HIAA/5-HT ratio and the path length at the second training session of the MWM task, although only for adult subjects. This was the only session where a significant difference between the performance of middle-aged and adult rats has occurred. Although the involvement of the hippocampus in learning and memory is well established, the present work shows, for the first time, a correlation between a serotonergic hippocampal parameter and performance of a spatial task, which is lost with ageing.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 94%

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Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze

Oliveira

Graeff²,

Pereira

et al. 2010

AGE

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“…A number of studies suggest that aged rats are slower to extinguish learned responses (Bevilaqua et al, 2008; Oliveira-Silva et al, 2007; Schneider-Rivas, Paredes-Carbajal, Mascher, Angoa-PéRez, Jaramillo-Gonzaléz, Borgonio-PéRez, & Rivas-Arancibia, 2007; Schneider-Rivas, Rivas-Arancibia, Vazquez-Pereyra, Vázquez-Sandoval, & Borgonio-Pérez, 1995; Topic, Dere, Schulz, de Souza Silva, Jocham, Kart, & Huston 2005; Topic, Huston, Namestkova, Zhu, Mohammed, & Schulz, 2008). However in the current study, we found that aged rats were unimpaired at extinguishing their behavior in the initial extinction session and were even faster to extinguish during the subsequent session.…”

Section: Discussionmentioning

confidence: 99%

Enhanced performance of aged rats in contingency degradation and instrumental extinction tasks.

Samson¹,

Venkatesh²,

Patel³

et al. 2014

Behavioral Neuroscience

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Normal aging in rats affects behavioral performance on a variety of associative learning tasks under Pavlovian conditions. There is little information, however, on whether aging also impacts performance of instrumental tasks. Young (9–12 mo) and aged (24–27 mo) Fisher 344 rats were trained to press distinct levers associated with either maltodextrin or sucrose. The rats in both age groups increased their lever press frequency at a similar rate, suggesting that the initial acquisition of this instrumental task is not affected by aging. Using a contingency degradation procedure, we then addressed whether aged rats could adapt their behavior to changes in action-outcome contingencies. We found that young and aged rats do adapt, but that a different schedule of reinforcement is necessary to optimize performance in each age group. Finally, we also addressed whether aged rats can extinguish a lever press action as well as young rats, using two forty minute extinction sessions on consecutive days. While extinction profiles were similar in young and aged rats on the first day of training, aged rats were faster to extinguish their lever presses on the second day, in spite of their performance levels being similar at the beginning of the session. Together these data support the finding that acquisition of instrumental lever press behaviors is preserved in aged rats, and suggest that they have a different threshold for switching strategies in response to changes in action-outcome associations. This pattern of result implies that age-related changes in the brain are heterogeneous and widespread across structures.

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“…Behavioral and molecular aspects of this decline have been studied extensively in the last two decades (see [80]). Recent studies have specifically demonstrated a decline of the capacity to extinguish in aged rats [81–84]. Perhaps the first to study this systematically in laboratory animals was Schneider-Rivas and his group.…”

Section: Aging and Extinctionmentioning

confidence: 99%

The Role of the Entorhinal Cortex in Extinction: Influences of Aging

et al. 2008

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The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex. Lesions or biochemical impairments of the entorhinal cortex hinder extinction. Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction. Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex.

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Age-related deficit in behavioural extinction is counteracted by long-term ethanol consumption: Correlation between 5-HIAA/5HT ratio in dorsal raphe nucleus and cognitive parameters

Cited by 22 publications

References 84 publications

Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze

Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze

Enhanced performance of aged rats in contingency degradation and instrumental extinction tasks.

The Role of the Entorhinal Cortex in Extinction: Influences of Aging

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