Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice

Tsukano, Hiroaki; Horie, Minoru; Honma, Yuusuke; Ohga, Shinpei; Hishida, Ryuichi; Takebayashi, Hirohide; Takahashi, Sugata; Shibuki, Katsuei

doi:10.1016/j.neulet.2013.10.015

Cited by 7 publications

(16 citation statements)

References 26 publications

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“…These data confirmed the presence of apparently separated AI high-frequency areas in mice. The regions overlapped to the places where Stiebler et al (1997) drew the UF and DP in their auditory cortical map, hereby referred to as Stiebler's UF and DP in this report, were confirmed by several studies ( Honma et al 2013 ; Joachimsthaler et al 2014 ; Stiebler et al 1997 ), and both areas are known to be activated by directional changes of slow FM sounds ( Honma et al 2013 ; Tsukano et al 2013b ). Moreover, cortical responses to ultrasonic sounds are not specific enough to divide the broad area into specific subareas.…”

Section: Resultssupporting

confidence: 82%

“…Optical imaging also revealed that a vacant region insensitive to pure tones containing vocalization-specific neurons is located between the AAF and AI dorsal high-frequency area ( Issa et al 2014 ), and we have already reported that the region between the AAF and DM is responsive to slow FM components, regardless of tonal frequency range ( Fig. 1 D ) ( Honma et al 2013 ; Tsukano et al 2013b ). These facts indicate that the distinct FM-sensitive region exists in this area in the mouse auditory cortex, similar to that observed in bats ( Suga and Jen 1976 ).…”

Section: Discussionmentioning

confidence: 59%

“…In vivo flavoprotein fluorescence imaging was performed, as described in our previous studies ( Takahashi et al 2006 ; Tsukano et al 2013b ). Mice were deeply anesthetized with urethane (1.7 g/kg ip; Wako, Osaka, Japan), and their rectal temperatures were maintained at 37°C.…”

Section: Methodsmentioning

confidence: 99%

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Delineation of a frequency-organized region isolated from the mouse primary auditory cortex

Tsukano

Horie

et al. 2015

Journal of Neurophysiology

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102

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The primary auditory cortex (AI) is the representative recipient of information from the ears in the mammalian cortex. However, the delineation of the AI is still controversial in a mouse. Recently, it was reported, using optical imaging, that two distinct areas of the AI, located ventrally and dorsally, are activated by high-frequency tones, whereas only one area is activated by low-frequency tones. Here, we show that the dorsal high-frequency area is an independent region that is separated from the rest of the AI. We could visualize the two distinct high-frequency areas using flavoprotein fluorescence imaging, as reported previously. SMI-32 immunolabeling revealed that the dorsal region had a different cytoarchitectural pattern from the rest of the AI. Specifically, the ratio of SMI-32-positive pyramidal neurons to nonpyramidal neurons was larger in the dorsal high-frequency area than the rest of the AI. We named this new region the dorsomedial field (DM). Retrograde tracing showed that neurons projecting to the DM were localized in the rostral part of the ventral division of the medial geniculate body with a distinct frequency organization, where few neurons projected to the AI. Furthermore, the responses of the DM to ultrasonic courtship songs presented by males were significantly greater in females than in males; in contrast, there was no sex difference in response to artificial pure tones. Our findings offer a basic outline on the processing of ultrasonic vocal information on the basis of the precisely subdivided, multiple frequency-organized auditory cortex map in mice.

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Section: Resultssupporting

confidence: 82%

Section: Discussionmentioning

confidence: 59%

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Delineation of a frequency-organized region isolated from the mouse primary auditory cortex

Tsukano

Horie

et al. 2015

Journal of Neurophysiology

Self Cite

102

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“…Therefore, we used 30-kHz and 60-kHz tones to obtain response shifts in the DM. To visualize neural responses in the frequency-unorganized regions of the DA and DP, which were localized on both sides of the DM, we used frequency modulation (FM) directional reverse stimuli 5 7 30 .…”

Section: Resultsmentioning

confidence: 99%

“…3b ) is similar to that already elucidated in the rat 26 34 38 . Moreover, the unspecific region (UR) in the rat auditory cortex 39 is in the same location as the non-tonotopical DA region in the mouse 4 5 7 30 . The agreement between these published investigations suggests a possibility that regions in the auditory cortex of the mouse and rat could be homologized in the future.…”

Section: Discussionmentioning

confidence: 99%

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Tsukano

Horie

Hishida

et al. 2016

Sci Rep

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Optical imaging studies have recently revealed the presence of multiple auditory cortical regions in the mouse brain. We have previously demonstrated, using flavoprotein fluorescence imaging, at least six regions in the mouse auditory cortex, including the anterior auditory field (AAF), primary auditory cortex (AI), the secondary auditory field (AII), dorsoanterior field (DA), dorsomedial field (DM), and dorsoposterior field (DP). While multiple regions in the visual cortex and somatosensory cortex have been annotated and consolidated in recent brain atlases, the multiple auditory cortical regions have not yet been presented from a coronal view. In the current study, we obtained regional coordinates of the six auditory cortical regions of the C57BL/6 mouse brain and illustrated these regions on template coronal brain slices. These results should reinforce the existing mouse brain atlases and support future studies in the auditory cortex.

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Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex

Horie¹,

Tsukano

Takebayashi³

et al. 2015

Neuroscience Letters

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Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice

Cited by 7 publications

References 26 publications

Delineation of a frequency-organized region isolated from the mouse primary auditory cortex

Delineation of a frequency-organized region isolated from the mouse primary auditory cortex

Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain

Specific distribution of non-phosphorylated neurofilaments characterizing each subfield in the mouse auditory cortex

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