Age-related deterioration of saccule-related neural function is associated with decreased estimated glomerular filtration rate and increased free thyroxine

Jung, Inhwa; Ahn, Su Hyun; Lee, Juyoung; Lee, Sun-Uk; Oh, Hui Jong; Kim, Hyo Jung; Choi, Jeong Yoon; Kim, Ji Soo

doi:10.1016/j.clinph.2019.02.002

Cited by 8 publications

(9 citation statements)

References 42 publications

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“…Aging affects the saccular function and its central processing in the vestibular nucleus and vestibulospinal tract (25). It is particularly true for the period from pre-school age to puberty and elderly patients (5,12,25). These findings are consistent with our results that VM patients with a longer history had more severe attacks.…”

Section: Discussionsupporting

confidence: 91%

“…Considering that VM and migraine partly share same neural circuits, including thalamus and amygdala, hormone triggering may play an important role in age-related variability in the clinical presentation of VM (4,12,26). A recent study showed systemic hormone factors like hyperthyroidism could hasten age-related deterioration of saccule-related neural function (25). Among the participants, especially among the elderly, women were obviously dominant, which indirectly demonstrated this point (23).…”

Section: Discussionmentioning

confidence: 94%

“…Although there were few studies on the natural history and related mechanisms in patients with VM, some reasonable hypotheses have been put forward on the fact that migraine and VM may share some common pathophysiology. This phenomenon may be related to the sharing of central and peripheral vestibular structures in older age (25). Aging affects the saccular function and its central processing in the vestibular nucleus and vestibulospinal tract (25).…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon may be related to the sharing of central and peripheral vestibular structures in older age (25). Aging affects the saccular function and its central processing in the vestibular nucleus and vestibulospinal tract (25). It is particularly true for the period from pre-school age to puberty and elderly patients (5,12,25).…”

Section: Discussionmentioning

confidence: 99%

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Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study

et al. 2020

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Objective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM.Methods: Adult participants with the diagnosis of VM or probable VM were enrolled according to the 2012 International Headache Society-Bárány Society Criteria. Every outpatient was followed up for 6 months to record the occurrence of VM attacks. Clinical data such as age, sex, number of VM attacks, severity on the visual analog scale, and lipid intake were collected and analyzed. Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Horne and Ostberg Morningness-Eveningness Questionnaires, and Pittsburgh Sleep Quality Index were also administered to find contributing factors.Results: During a 6-month clinical follow-up, 313 VM attack were reported. According to the Visual Analog Scale, the patients were divided into two groups. Then univariate and multivariable analyses were conducted. Among the risk factors, duration of illness (adjusted OR, 1.041; 95% CI, 1.010–1.073; P = 0.009), time of onset: 00:00:00–12:00:00 (adjusted OR, 3.961; 95% CI, 1.966–7.979; P < 0.001) and PSQI scores (adjusted OR, 1.086; 95% CI, 1.002–1.178; P = 0.046) were significantly associated with the severity of VM attack assessed by VAS.Conclusion: The data suggest that patients tended to experienced more severe VM attacks in early hours of a day, especially for those sufferers with longer duration of illness or poor sleep quality. Targeted management of such factors is required to reduce the severity of attacks.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study

et al. 2020

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“…For patients who were willing to undergo an evaluation for dizziness, the laboratory audio‐vestibular function tests were evaluated selectively using three‐dimensional (3D) video‐oculography, video head impulse tests (video‐HITs), cervical and ocular vestibular evoked myogenic potentials (VEMPs), active orthostatic blood pressure, the tilt table test, and pure tone audiometry. The protocols of 3D video‐oculography, video‐HITs, and cervical and ocular VEMPs have been presented elsewhere 11–14 . For the active orthostatic blood pressure test, we measured the baseline pressure and heart rate in the supine position after a 3‐min rest and at 1, 3, and 5 min after standing up 15 .…”

Section: Methodsmentioning

confidence: 99%

Vestibular syncope: clinical characteristics and mechanism

Kwon

Kim

et al. 2022

Ann Clin Transl Neurol

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Background and Objectives: Vestibular syncope is a condition in which vertigo-induced hemodynamic changes cause syncope. This study investigated the clinical and laboratory findings of vestibular syncope and tried to refine our knowledge of the mechanism underlying this newly recognized entity. Methods: This study retrospectively analyzed 53 patients (33 women, median age = 63 years [interquartile range = 54-71 years]) with vestibular syncope from January 2017 to December 2021. To explain the mechanism of vestibular syncope, we incorporated a velocity-storage model into the dual reflex pathways comprising the vestibulo-sympathetic reflex and baroreflex and predicted the cardiovascular responses. Results: Twenty (37.7%) patients had multiple episodes of vestibular syncope, and seven (13.2%) had potentially life-threatening injuries. Meniere's disease (20.8%) and benign paroxysmal positional vertigo (9.4%) were the most common underlying vestibular disorders. Abnormal vestibular function tests included impaired cervical vestibular-evoked myogenic potentials (57.5%) and positive head impulse tests (31.0%). Orthostatic hypotension was found in 19.5% of patients. Dyslipidemia (30.2%) and hypertension (28.3%) were common medical comorbidities. The dual reflex pathways incorporating the function of the velocity-storage circuit in the brainstem and cerebellum suggest that vestibular syncope is a neurally mediated reflex syncope associated with a sudden hemodynamic change during vertigo. This change can be arterial hypertension triggered by a false downward inertial cue, as suggested previously, or hypotension driven by a false upward inertial cue. Conclusions: Vestibular syncope is associated with various vestibular disorders and requires careful evaluation and intervention to prevent recurrent falls and significant injuries.

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Linear Vertigo in Benign Paroxysmal Positional Vertigo: Prevalence and Mechanism

et al. 2020

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Age-related deterioration of saccule-related neural function is associated with decreased estimated glomerular filtration rate and increased free thyroxine

Cited by 8 publications

References 42 publications

Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study

Severity and Its Contributing Factors in Patients With Vestibular Migraine: A Cohort Study

Vestibular syncope: clinical characteristics and mechanism

Linear Vertigo in Benign Paroxysmal Positional Vertigo: Prevalence and Mechanism

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