Aggravierung der durch Staphylococcus aureus bei Ratten ausgelösten Pyelonephritis durch Morphin und D-Aspartinsäure

Koyuncuoğlu, H; Güngör, Mehmet Ali̇; Anǧ, Özdem; Inanç, D; Anğ-Küçüker, Mine; Sağduyu, H.; Uysal, Murat

doi:10.1007/bf01646931

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…d-Asp. d-Asp aggravated the nephritis in rats induced by Staphylococcus aureus bacteria [151] and prevented K and Mg depletion in rats induced by diuretics [152].…”

Section: 4mentioning

confidence: 99%

Origin, Microbiology, Nutrition, and Pharmacology of D‐Amino Acids

Friedman

2010

Chemistry & Biodiversity

162

108

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Exposure of food proteins to certain processing conditions induces two major chemical changes: racemization of all L-amino acids (LAAs) to D-amino acids (DAAs) and concurrent formation of cross-linked amino acids such as lysinoalanine (LAL). The diet contains both processing-induced and naturally-formed DAA. The latter include those found in microorganisms, plants, and marine invertebrates. Racemization impairs digestibility and nutritional quality. Racemization of LAA residues to their D-isomers in food and other proteins is pH-, time-, and temperature-dependent. Although racemization rates of LAA residues in a protein vary, relative rates in different proteins are similar. The nutritional utilization of different DAAs varies widely in animals and humans. Some DAAs may exert both adverse and beneficial biological effects. Thus, although D-Phe is utilized as a nutritional source of L-Phe, high concentrations of D-Tyr in such diets inhibit the growth of mice. Both D-Ser and LAL induce histological changes in the rat kidney. The wide variation in the utilization of DAAs is illustrated by the fact that, whereas D-Meth is largely utilized as a nutritional source of the L-isomer, D-Lys is not. Similarly, although L-CysSH has a sparing effect on L-Meth when fed to mice, D-CysSH does not. Since DAAs are consumed as part of their normal diet, a need exists to develop a better understanding of their roles in foods, microbiology, nutrition, and medicine. To contribute to this effort, this overview surveys our present knowledge of the chemistry, nutrition, safety, microbiology, and pharmacology of DAAs. Also covered are the origin and distribution of DAAs in food and possible roles of DAAs in human physiology, aging, and the etiology and therapy of human diseases.

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“…d-Asp. d-Asp aggravated the nephritis in rats induced by Staphylococcus aureus bacteria [151] and prevented K and Mg depletion in rats induced by diuretics [152].…”

Section: 4mentioning

confidence: 99%

Origin, Microbiology, Nutrition, and Pharmacology of D‐Amino Acids

Friedman

2010

Chemistry & Biodiversity

162

108

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“…Overall, respiratory tract infections caused by S. pneumoniae, S. aureus, K. pneumoniae, Mycobacterium, Staphylococcus, Haemophilus, and other bacteria are among the most common diagnoses of this IDUs (Hind 1990; Perlman et al 1995). The data from animal model showed that opioid treatment causes increased susceptibility and mortality to various bacterial infections, including S. pneumoniae (Wang et al 2005b, 2008a), K. pneumoniae (Tubaro et al 1983), acute Toxoplasma gondii (Chao et al 1990), oral Salmonella typhimurium (Feng et al 2006a), Candida albicans (Szabo et al 1993), Acinetobacter baumannii (Lee et al 2007), S. aureus (Koyuncuoglu et al 1988), and Listeria monocytogenes (Asakura et al 2006). Although opiate addiction has been identified as a risk factor for clinical tuberculosis (Durante et al 1998), an in vitro infection study (Peterson et al 1995; Rock et al 2004), contrary to other bacterial infection studies, showed that morphine stimulated the phagocytosis of M. tuberculosis by human microglial cells, the resident macrophages of the brain.…”

Section: Opiates and Microtranslocationmentioning

confidence: 99%

Opioids and HIV/HCV Infection

Wang

Zhang

2011

J Neuroimmune Pharmacol

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Since human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share the same modes of transmission and common risk factors for infection, co-infections with HIV and HCV are frequently found in injection drug users (IDUs). IDUs represent one of the largest reservoirs of HIV as well as HCV in the United States. These two pathogens are also likely to be responsible for the highest infectious disease morbidity and mortality rates among IDUs. IDUs frequently involve the abuse of heroin, the most common abused opiate. Opiates have been suggested to have a cofactor role in the immunopathogenesis of HIV disease, as they have the potential to compromise host immune responses and enhances microbial infections. Although in vitro studies have yielded relatively agreeable data that morphine, the active metabolite of heroin, exacerbate HIV infection/replication, epidemiologic studies as well as in vivo non-human primate investigations on the impact of opiate abuse on HIV disease progression have yielded the conflicting data. Given immunomodulation and immunocompromising effect as well as demonstrated impact to enhance HIV replication in vitro, it is reasonable to believe that opiate abuse is a facilitator in HIV and/or HCV disease progression. However, much remain to be learned about the mechanisms of opiate-mediated broad influence on host immunity and viral expression. Thus, more extensive studies are needed in order to determine the effects of different conditions of opiate abuse and to define the understanding of the role of opiate in modulating HIV and/ or HCV disease progression.

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“…Experimental animal studies showed that opioid treatment causes increased susceptibility and mortality to various bacterial infections, including S. pneumoniae [87,88], K. pneumoniae [86], acute Toxoplasma gondii [11], oral Salmonella typhimurium [24], Candida albicans [81], Acinetobacter baumannii [40], S. aureus [38], and Listeria monocytogenes [2]. Although opiate addiction has been identified as a risk factor for clinical tuberculosis [17], an in vitro infection study, contrary to other bacterial infection studies, showed that morphine stimulated the phagocytosis of M. tuberculosis by human microglial cells, the resident macrophages of the brain.…”

Section: Opiate Abuse Affects Bacterial Infection In Animal Modelsmentioning

confidence: 99%

Opiate abuse, innate immunity, and bacterial infectious diseases

Wang

Barke

et al. 2008

Arch. Immunol. Ther. Exp.

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The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body's first line of defense against harmful external bacteria. Opiate, for example morphine, abuse degrades physical and physiologic barriers, and modulates phagocytic cells (macrophages, neutrophils) and, nonspecific cytotoxic T cells (gammadelta T), natural killer cells, and dendritic cells, that are functionally important for carrying out a rapid immune reaction to invading pathogens. In vitro studies with innate immune cells from experimental animals and humans and in vivo studies with animal models have shown that opiate abuse impairs innate immunity and is responsible for increased susceptibility to bacterial infection. However, to better understand the complex interactions between opiates, innate immunity, and bacterial infection and develop novel approaches to treat and even prevent bacterial infection in the opiate-abuse population, there is an urgent need to fill the numerous gaps in our understanding of the cellular and molecular mechanisms by which opiate abuse increases susceptibility to bacterial infection.

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Aggravierung der durch Staphylococcus aureus bei Ratten ausgelösten Pyelonephritis durch Morphin und D-Aspartinsäure

Cited by 9 publications

References 21 publications

Origin, Microbiology, Nutrition, and Pharmacology of D‐Amino Acids

Origin, Microbiology, Nutrition, and Pharmacology of D‐Amino Acids

Opioids and HIV/HCV Infection

Opiate abuse, innate immunity, and bacterial infectious diseases

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