Aggregation of magnetic microparticles in the context of targeted therapies actuated by a magnetic resonance imaging system

Mathieu, Jean-Baptiste

doi:10.1063/1.3159645

Cited by 47 publications

(34 citation statements)

References 30 publications

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“…Shear‐enhanced magnetic aggregation (19) of the particles takes place. As reported in (20), with the same experimental conditions, manual length measurement of the magnetic aggregates formed in the imaging magnet with 0 mT/m gradient amplitude yields aggregates with lengths of 650 ± 410 μm. The average length is likely to have been overestimated since the pixel size of the camera is not adequate to resolve the smallest aggregates.…”

Section: Resultssupporting

confidence: 54%

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

Mathieu

Martel

2010

Magnetic Resonance in Med

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101

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Upgraded gradient coils can effectively enhance the MRI steering of magnetic microparticles in a branching channel. Applications of this method include MRI targeting of magnetic embolization agents for oncologic therapy. A magnetic suspension of Fe 3 O 4 magnetic particles was injected inside a yshaped microfluidic channel. Magnetic gradients of 0, 50, 100, 200, and 400 mT/m were applied to the magnetic particles perpendicularly to the flow by a custom-built gradient coil inside a 1.5-T MRI scanner. Measurement of the steering ratio was performed both by video analyses and quantification of the mass of the particles collected at each outlet of the microfluidic channel, using atomic absorption spectroscopy. Magnetic particles steering ratios of 0.99 and 0.75 were reached with 400 mT/m gradient amplitude and measured by video analyses and atomic absorption spectroscopy, respectively. Experimental data shows that the steering ratio increases with higher magnetic gradients. Moreover, theory suggests that larger particles (or aggregates), higher magnetizations, and lower flows can also be used to improve the steering ratio. The technological limitation of the approach is that an MRI gradient amplitude increase to a few hundred milliteslas per meter is needed. A simple analytical method based on magnetophoretic velocity predictions and geometric considerations is proposed for steering ratio calculation. Magn Reson Med 63:1336-1345,

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Section: Resultssupporting

confidence: 54%

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

Mathieu

Martel

2010

Magnetic Resonance in Med

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101

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“…(ii) Augmenting the magnetic volume of the guided therapeutic agents either by performing aggregation techniques (86)(87)(88) or by encapsulating the therapeutic agents inside biodegradable polymers (89).…”

Section: Discussionmentioning

confidence: 99%

“…The formation of aggregations, due to the MRI field, increases the magnetic volume, which in turn gives rise to larger ratio of magnetic forces over drag forces (86)(87)(88). An alternative approach is followed in (89),…”

Section: Magnetic Propulsion and Steeringmentioning

confidence: 99%

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Vartholomeos

Fruchard

Ferreira

et al. 2011

Annu. Rev. Biomed. Eng.

103

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International audienceThis review presents the state of the art of magnetic resonance imaging(MRI)-guided nanorobotic systems that can perform diagnostic, curative,and reconstructive treatments in the human body at the cellular and subcellular levels in a controllable manner. The concept of an MRI-guided nanorobotic system is based on the use of an MRI scanner to induce the required external driving forces to propel magnetic nanocapsules to a specific target. It is an active targeting mechanism that provides simultaneous propulsion and imaging capabilities, which allow the implementation of real-time feedback control of the targeting process. The architecture of the system comprises four main modules: (a) the nanocapsules, (b) the MRI propulsion module, (c) theMRI trackingmodule (for image processing), and (d ) the controller module. A key concept is the nanocapsule technology, which is based on carriers such as liposomes, polymermicelles, gold nanoparticles, quantum dots, metallic nanoshells, and carbon nanotubes. Descriptions of the significant challenges faced by theMRI-guided nanorobotic system are presented, and promising solutions proposed by the involved research community are discussed. Emphasis is placed on reviewing the limitations imposed by the scaling effects that dominate within the blood vessels and also on reviewing the control algorithms and computational tools that have been developed for real-time propulsion and tracking of the nanocapsules

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“…These predictions fit the experimental data assuming that the aggregate size does not change significantly. The importance of magnetic dipole interactions for targeting applications have been described previously [21][22][23]. Also there have been previous publications where a similar bifurcation has been modelled but in the context of permanent magnets and without cell aggregation [24,25].…”

Section: Effect Of Viscosity and Cell Concentrationmentioning

confidence: 95%

Magnetically assisted delivery of cells using a magnetic resonance imaging system

Riegler¹,

Allain²,

Cook³

et al. 2011

J. Phys. D: Appl. Phys.

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To cite this version:J Riegler, B Allain, R J Cook, M F Lythgoe, Q A Pankhurst. Magnetically assisted delivery of cells using a magnetic resonance imaging system. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (5) AbstractA simple analytical model is presented which enables rapid interactive prediction and control of magnetically labelled cells in an arterial bifurcation using magnetic field gradients produced by a magnetic resonance imaging system (MRI). This model is compared against experimental results for human mononuclear cells labelled with micron sized superparamagnetic iron oxide particles. Experimental and theoretical results highlight the importance of cell aggregation for magnetic targeting in a strong magnetic field. These predicted aggregates are confirmed via confocal endoscopy which allows the visualisation of cell aggregates and their movement inside a vascular flow model in a 9.4T preclinical MRI scanner.

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Aggregation of magnetic microparticles in the context of targeted therapies actuated by a magnetic resonance imaging system

Cited by 47 publications

References 30 publications

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner

MRI-Guided Nanorobotic Systems for Therapeutic and Diagnostic Applications

Magnetically assisted delivery of cells using a magnetic resonance imaging system

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