Aggressive advanced gastric cancer in a patient with autosomal dominant polycystic kidney disease

Yasuda, Takeshi; Ishikawa, Takeshi; Hirose, Ryohei; Doi, Takehiko; Inoue, Ken; Dohi, Osamu; Yoshida, Naohisa; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Takagi, Tomohisa; Konishi, Hideyuki; Inamori, Osamu; Morinaga, Yukiko; Konishi, Eiichi; Naito, Yuji; Itoh, Yoshito

doi:10.1007/s12328-021-01407-5

Cited by 1 publication

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yasuda et al conducted a population-based cohort which reported that PKD patients had a higher chance of developing gastric cancer [ 8 ]. In such patients, the cancer diagnosis and prognosis are related to the proliferation of cells and their differentiation, migration, polarity, and apoptosis [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…While each condition individually demands meticulous attention and tailored management, the juxtaposition of gastric cancer with polycystic kidney and liver disease raises intriguing questions about the intricate interplay of these disparate pathologies. To our knowledge, only eight cases have been reported so far which discuss the correlation and pathophysiology of gastric cancer's association with polycystic disease of the kidneys [3][4][5][6][7][8][9]. This case report aims to present a comprehensive analysis of the patient's clinical history, diagnostic journey, and subsequent management.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Report of the Coexistence of Gastric Cancer With Polycystic Kidney and Liver Disease: Unveiling the Complexity

Girme,

Gupta

2024

Cureus

View full text Add to dashboard Cite

Polycystic kidney disease (PKD) is a genetic disorder that comprises multiple cystic lesions in the kidneys. The association of PKD with gastric cancer has been studied. We present a rare presentation of stomach cancer with polycystic liver and kidney disease. A male patient in his 40s presented with epigastric pain, nausea, retrosternal burning, and occasional episodes of vomiting. Esophagogastroduodenoscopy revealed ulceroproliferative growth in the prepyloric region. Biopsies revealed moderately differentiated adenocarcinoma which was confirmed by contrast-enhanced computed tomography of the abdomen and pelvis. This showed a chance finding of polycystic kidney and liver disease. After confirmation with a positron emission tomography scan, the patient was diagnosed with gastric carcinoma (cT3N1M0, Stage IIB) with polycystic kidney and liver disease. We provide a case of early-stage stomach cancer in a patient with PKD. More extensive research is needed for a better understanding of this association between polycystic kidney and liver disease and gastric cancer development, to achieve earlier diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%