Aggressive necrotizing pseudomonal sinonasal infections

Kuan, Edward C.; Tajudeen, Bobby A.; Welch, Kevin C.; Chandra, Rakesh K.; Glasgow, Ben J.; Suh, Jeffrey D.

doi:10.1002/alr.21981

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Moreover, impaired epithelial integrity is accompanied with increased cytotoxic effect of P. aeruginosa on host epithelial cells (Fleiszig et al, 1997a; Lee et al, 1999) (Figure 1B). In some cases, aggressive, recalcitrant P. aeruginosa sinonasal infections have been shown associated with severe tissue necrosis (Kuan et al, 2017).…”

Section: Evidence For Epithelial Integrity Alterations By Pseudomonasmentioning

confidence: 99%

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

Ruffin

Brochiero

2019

Front. Cell. Infect. Microbiol.

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Epithelial tissues protecting organs from the environment are the first-line of defense against pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain epithelial integrity. However, these healing processes can be insufficient to restore epithelial integrity, notably in infectious conditions. Pseudomonas aeruginosa infections in cutaneous, corneal, and respiratory tract epithelia are of particular concern because they are the leading causes of hospitalizations, disabilities, and deaths worldwide. Pseudomonas aeruginosa has been shown to alter repair processes, leading to chronic wounds and infections. Because of the current increase in the incidence of multi-drug resistant isolates of P. aeruginosa , complementary approaches to decrease the negative impact of these bacteria on epithelia are urgently needed. Here, we review the recent advances in the understanding of the impact of P. aeruginosa infections on the integrity and repair mechanisms of alveolar, airway, cutaneous and corneal epithelia. Potential therapeutic avenues aimed at counteracting this deleterious impact of infection are also discussed.

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Section: Evidence For Epithelial Integrity Alterations By Pseudomonasmentioning

confidence: 99%

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

Ruffin

Brochiero

2019

Front. Cell. Infect. Microbiol.

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“…It also releases exopolysaccharide alginate [12], which is utilized to build biofilm [13]. Lipases and phospholipases, which target lipids in the surfactant and host cell membranes, are further pathogenic agents of the bacteria [14]. As well as exoenzymes S, T, U, and Y [15].…”

mentioning

confidence: 99%

Virulence factors in Pseudomonas aeruginosa: The arms race between bacteria and humans

AL-Khikani

2021

Microbes and Infectious Diseases

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“…The abundance of inflammatory cells and the culture of specific bacteria, particularly Klebsiella and Pseudomonas species, point to a bacterial cause of the necrotic sinonasal infection. 5,6 Authors' Note…”

mentioning

confidence: 99%

Necrotizing Bacterial Rhinitis in an Immunocompromised Patient

et al. 2020

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Specific bacterial infections can cause rapid necrosis of the nasal mucosa in immunocompromised patients, mimicking an invasive fungal infection. The exclusion of the latter is a priority because rapid deterioration and death may ensue within hours to days. The time lag between investigations and final diagnosis warrants empiric administration of Amphotericin B but patients are exposed to significant side effects. Histopathology and culture of the nasal tissues provide the necessary diagnostic clues to avoid inappropriate treatment.

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Aggressive necrotizing pseudomonal sinonasal infections

Cited by 7 publications

References 11 publications

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

Virulence factors in Pseudomonas aeruginosa: The arms race between bacteria and humans

Necrotizing Bacterial Rhinitis in an Immunocompromised Patient

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