Aglycone solanidine and solasodine derivatives: A natural approach towards cancer

Hameed, Abdul; Ijaz, S.; Mohammad, Imran Shair; Muhammad, Kiran Sher; Akhtar, Naveed; Khan, Haji Muhammad Shoaib

doi:10.1016/j.biopha.2017.07.147

Cited by 30 publications

(19 citation statements)

References 99 publications

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“…Solasodine, a naturally occurring aglycone of glycoalkaloid, displayed antitumor activity in different cancers by inhibiting the GSK-3β pathway and inducing apoptosis. 92,93 AR-A014418, a highly specific GSK-3β inhibitor, enhanced the cytotoxic effects of temozolomide and gemcitabine in models of GBM and pancreatic cancer, respectively. 75 A preclinical study using AR-A014418 demonstrated that inhibition of GSK-3 decreased gastric cancer cell survival and proliferation through decreasing telomerase reverse transcriptase expression and telomerase activity.…”

Section: Gsk-3β Inhibitorsmentioning

confidence: 99%

Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses

Şahin

Eturi

Souza

et al. 2019

Cancer Biology & Therapy

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As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3β) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3β inhibitor has been approved for the treatment of cancer. The regulatory role of GSK-3β in apoptosis, cell cycle, DNA repair, tumor growth, invasion, and metastasis reflects the therapeutic relevance of this target and provides the rationale for drug combinations. Emerging data on GSK-3β as a mediator of anticancer immune response also highlight the potential clinical applications of novel selective GSK-3β inhibitors that are entering clinical studies. This manuscript reviews the preclinical and early clinical results with GSK-3β inhibitors and delineates the developmental therapeutics landscape for this potentially important target in cancer therapy.

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Section: Gsk-3β Inhibitorsmentioning

confidence: 99%

Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses

Şahin

Eturi

Souza

et al. 2019

Cancer Biology & Therapy

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“…Thus, play a pivotal role to prevent and cure oxidative stress based diseases (Niki, 2010). In this respect, many plants have been proved an important source of naturally occurring antioxidants (Mohammad et al, 2015;Phil et al, 2018) and showed numerous promising therapeutic effects (Hameed et al, 2017;Mohammad, He, Yin, 2018).…”

Section: Introductionmentioning

confidence: 99%

Polymeric emulgel carrying Cinnamomum tamala extract: promising delivery system for potential topical applications

Arshad

Khan

Akhtar

et al. 2020

Braz. J. Pharm. Sci.

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Currently, the use of natural compounds obtained from plants tremendously increased due to their promising therapeutic properties. The aim of this study was to formulate a stable emulgel formulation loaded with Cinnamomum tamala (CT) extract. The antioxidant activity of plant extract was determined by DPPH inhibition assay. The extract was successfully loaded into an emulgels using different concentrations of carbopol-940, liquid paraffin, emulsifying agents and preservatives. Preliminary stability study was performed of 17 CT emulgel formulations at accelerated temperature of 50 °C for 2-months. Organoleptic evaluation, centrifugation, globule size, pH, electrical conductivity and rheological studies were performed for a period of 90-days at different temperature including 8, 25, 40 and 40 °C ±75% RH. The CT extract showed promising antioxidant activity of about 81%. On the other hand, the CT loaded emulgel formulation displayed high physical stability at all tested conditions of temperature and time. However, slight decrease in pH and minimum increase in conductivity was observed at 40 and 40 °C±75% RH. The rheological examination of CT emulgel indicated the flow index values of all the samples kept at different temperatures were less than 1, demonstrated non-newtonian and pseudo-plastic nature of CT emulgel. Taken together, the CT emulgel formulation has been evinced to be an excellent addition in the field of topical formulations.

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“…These plants produce different classes of compounds including alkaloids and glycoalkaloids (GAs). GAs exhibit also a wide range of pharmacological properties, including anticancer activity or acetylcholinesterase (AChE) inhibitory activity [7,8]. This latter is associated with the treatment of several diseases such as Alzheimer’s (AD) or Parkinson diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Glycoalkaloids (GAs), a class of nitrogen-containing secondary metabolites, are commonly found in the Solanaceae family and play an important role in the defence of the plant against pests [6]. Although toxic for human health at certain levels, GAs also exhibit a wide range of pharmacological properties, including anticancer activity [7,8,9,10]. Many GAs exhibit acetylcholinesterase (AChE) inhibitory activity, which is associated with the treatment of several diseases such as Alzheimer’s disease (AD), Myasthenia gravis , and glaucoma as well as the mechanisms of insecticidal activity and anthelmintic drugs [11].…”

Section: Introductionmentioning

confidence: 99%

A Complete Survey of Glycoalkaloids Using LC-FTICR-MS and IRMPD in a Commercial Variety and a Local Landrace of Eggplant (Solanum melongena L.) and their Anticholinesterase and Antioxidant Activities

Lelario

Maria

Rivelli

et al. 2019

Toxins

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Eggplant contains glycoalkaloids (GAs), a class of nitrogen-containing secondary metabolites of great structural variety that may have both adverse and beneficial biological effects. In this study, we performed a complete survey of GAs and their malonylated form, in two genotypes of eggplants: A commercial cultivated type, Mirabella (Mir), with purple peel and bitter taste and a local landrace, named Melanzana Bianca di Senise (Sen), characterized by white peel with purple strip and a typical sweet aroma. Besides the analysis of their morphological traits, nineteen glycoalkaloids were tentatively identified in eggplant berry extracts based upon LC-ESI-FTICR-MS analysis using retention times, elution orders, high-resolution mass spectra, as well as high-resolution fragmentation by IRMPD. The relative signal intensities (i.e., ion counts) of the GAs identified in Mir and Sen pulp extracts showed as solamargine, and its isomers are the most abundant. In addition, anticholinesterase and antioxidant activities of the extracts were evaluated. Pulp tissue was found to be more active in inhibiting acetylcholinesterase enzyme than peel showing an inhibitory effect higher than 20% for Mir pulp. The identification of new malonylated GAs in eggplant is proposed.

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Aglycone solanidine and solasodine derivatives: A natural approach towards cancer

Cited by 30 publications

References 99 publications

Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses

Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses

Polymeric emulgel carrying Cinnamomum tamala extract: promising delivery system for potential topical applications

A Complete Survey of Glycoalkaloids Using LC-FTICR-MS and IRMPD in a Commercial Variety and a Local Landrace of Eggplant (Solanum melongena L.) and their Anticholinesterase and Antioxidant Activities

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