2019
DOI: 10.1016/j.abb.2019.108164
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Agonism of GPR39 displays protective effects against advanced glycation end-product (AGE)-induced degradation of extracellular matrix in human SW1353 cells

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Cited by 15 publications
(12 citation statements)
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“…The expression of GPR39 in the hippocampus and hippocampal cells (HT-22) was upregulated following administration of TC-G 1008 [21,28]. Advanced glycation end products reduced GPR39 expression in a dose-dependent manner and TC-G 1008 reversed the effects of AGEs [47]. In this study, GPR39 was upregulated post TC-G 1008 administration as seen from our immuno uorescence staining and mechanism studies, which is consistent with previous studies.…”
Section: Discussionsupporting
confidence: 91%
“…The expression of GPR39 in the hippocampus and hippocampal cells (HT-22) was upregulated following administration of TC-G 1008 [21,28]. Advanced glycation end products reduced GPR39 expression in a dose-dependent manner and TC-G 1008 reversed the effects of AGEs [47]. In this study, GPR39 was upregulated post TC-G 1008 administration as seen from our immuno uorescence staining and mechanism studies, which is consistent with previous studies.…”
Section: Discussionsupporting
confidence: 91%
“…The expression of GPR39 in the hippocampus and hippocampal cells (HT-22) was upregulated following administration of TC-G 1008 [ 21 , 28 ]. Advanced glycation end-products reduced GPR39 expression in a dose-dependent manner and TC-G 1008 reversed the effects of AGEs [ 47 ]. In this study, GPR39 was upregulated post-TC-G 1008 administration as seen from our immunofluorescence staining and mechanism studies, which is consistent with previous studies.…”
Section: Discussionmentioning
confidence: 99%
“…The activation of GPR39 has been associated with reduced monocyte-to-endothelial adhesion [50] and reduced cardiovascular calcification [21,23]. GPR39 agonism further ameliorates the extracellular matrix degradation in chondrocytes induced by advanced glycation end-products [51]. The antiinflammatory effects of GPR39 activation can be observed in fibroblast-like synoviocytes after TNFα treatment [52].…”
Section: Discussionmentioning
confidence: 99%