AIDS‐assoziierte disseminierte Talaromyces marneffei‐Mykose (vormals Penicillium marneffei‐Mykose)

Li, Qiaofei; Wang, Chuqiang; Zeng, Kang; Peng, Xiaoming; Wang, Fang

doi:10.1111/ddg.13663_g

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Electronic medical records of HIV-infected patients diagnosed with TM bloodstream infection (defined by a culture positive for TM from patient blood) were searched. Information including place of birth or long-term residence, presenting complaints and physical examinations (fever, umbilical fovea-like rash [ 18 ], and superficial lymphadenopathy), and laboratory tests (routine blood test, biochemistry, PCT, CD4 and CD8 cell counts, CRP ) and outcomes during hospitalization were analyzed. Blood culture were performed on patients with fever, loss of weight, lymphadenopathy or other symptoms considering infection on the time of admission, and routine blood tests and tests for biochemistry, cellular immune function, PCT and CRP were measured at the same time.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

Sun

Tang

et al. 2021

BMC Infect Dis

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Background Talaromyces marneffei (TM) bloodstream infection is common in Acquired Immunodeficiency Syndrome (AIDS) patients with extreme immunodeficiency in Southeast Asia and South China, however, clinical case study on TM bloodstream infection is scarce. We retrospectively analyzed the clinical characteristics of TM bloodstream infection in hospitalized AIDS patients and determined the outcomes of hospitalization after diagnosis in our hospital over the past 5 years. Methods From January 2015 to July 2020, 87 cases of TM detected by blood culture in patients admitted to our center were collected. The admission complaints, blood cells, biochemistry, CD4 and CD8 cell counts and 1,3-β-D-glucan (BDG), procalcitonin (PCT), CRP level on the day of blood culture test, and outcomes during hospitalization were analyzed. Logistic regression analysis was performed for the risk factors for poor prognosis (60 cases). Spearman correlation analysis was used to analyze the correlation between peripheral blood cells, albumin and the time required for TM turnaround in blood culture. The difference was statistically significant when the P value was < 0.05. Results A total of 87 patients were collected, with a median age of 34 years, a median hemoglobin of 94 g/L and CD4 count of 7/μl. The rate of TM bloodstream infection among all in-hospital patients increased from 0.99% in 2015 to 2.09% in 2020(half year). Patients with TM bloodstream infection with CD8 count < 200/μl had a 12.6-fold higher risk of poor prognosis than those with CD8 count > 200/μl (p = 0.04), and those with BDG < 100 pg/mL had a 34.9-fold higher risk of poor prognosis than those with BDG > 100 pg/mL (p = 0.01). Conclusions TM bloodstream infection is becoming more common in advanced AIDS patients in endemic areas. For those patients with extremely low CD4 and CD8 cell counts below 200/μl is with an increased risk of poor prognosis.

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Section: Methodsmentioning

confidence: 99%

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

Sun

Tang

et al. 2021

BMC Infect Dis

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Dermatoscopy for the rapid diagnosis of Talaromyces marneffei infection: a case report

Jian

Huang

et al. 2019

BMC Infect Dis

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Background: Talaromyces marneffei is a thermally dimorphic fungus endemic in southeast Asia. It predominantly occurs in both immunocompromised and immunosuppressed patients and can be fatal if diagnosis and treatment are delayed. The clinical manifestations of T. marneffei infection are nonspecific and rapid diagnosis of T. marneffei infection remains challenging. Case presentation: A 24-year-old man came to our outpatient department with the sign of common skin lesions. The lesions were cuticolor follicular papules with or without central umbilication, nodules and acne-like lesions, which are common in syringoma, steatocystoma multiplex and trichoepithelioma. A dermatoscopy examination was performed to differentiate these skin lesions. The dermatoscopic images revealed circular or quasi-circular whitish amorphous structure with a central brownish keratin plug, providing the diagnostic clues of T. marneffei infection. Therefore, a skin scrapings culture, skin biopsy and serological detection for human immunodeficiency virus (HIV) were performed. The final diagnosis of this patient was T. marneffei and HIV co-infection. Conclusion: Rapid diagnosis of T. marneffei infection is clinically challenging since presenting clinical manifestations are nonspecific with significant overlap with other common conditions. This case highlights that dermatoscopy is a promising tool for the rapid diagnosis of T. marneffei infection in patients with nonspecific skin lesions, assisting clinicians to avoid delayed diagnosis or misdiagnosis.

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Named signs and metaphoric terminologies in dermoscopy: A compilation

Das¹,

Madke

Jakhar

et al. 2022

IJDVL

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Rosette signActinic keratosis, basal cell carcinoma, melanoma, discoid lupus erythematosus, molluscum Four white points arranged as four-leaf clover. Non-specific, initially described in AK but seen in many conditions Spoke wheel-like structures Basal cell carcinomaRadial projections surrounding a central darker point Strawberry pattern 13 Actinic keratosis Background erythema interrupted by multiple small keratin filled follicular ostia

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AIDS‐assoziierte disseminierte Talaromyces marneffei‐Mykose (vormals Penicillium marneffei‐Mykose)

Cited by 3 publications

References 2 publications

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

Clinical characteristics and risk factors for poor prognosis among HIV patients with Talaromyces marneffei bloodstream infection

Dermatoscopy for the rapid diagnosis of Talaromyces marneffei infection: a case report

Named signs and metaphoric terminologies in dermoscopy: A compilation

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