Covid19-induced lockdown measures caused modifications in atmospheric pollutant and greenhouse gas emissions. Urban road traffic was the most impacted, with 48–60% average reduction in Italy. This offered an unprecedented opportunity to assess how a prolonged (∼2 months) and remarkable abatement of traffic emissions impacted on urban air quality. Six out of the eight most populated cities in Italy with different climatic conditions were analysed: Milan, Bologna, Florence, Rome, Naples, and Palermo. The selected scenario (24/02/2020–30/04/2020) was compared to a meteorologically comparable scenario in 2019 (25/02/2019–02/05/2019). NO
2
, O
3
, PM
2.5
and PM
10
observations from 58 air quality and meteorological stations were used, while traffic mobility was derived from municipality-scale big data.
NO
2
levels remarkably dropped over all urban areas (from −24.9% in Milan to −59.1% in Naples), to an extent roughly proportional but lower than traffic reduction. Conversely, O
3
concentrations remained unchanged or even increased (up to 13.7% in Palermo and 14.7% in Rome), likely because of the reduced O
3
titration triggered by lower NO emissions from vehicles, and lower NO
x
emissions over typical VOCs-limited environments such as urban areas, not compensated by comparable VOCs emissions reductions. PM
10
exhibited reductions up to 31.5% (Palermo) and increases up to 7.3% (Naples), while PM
2.5
showed reductions of ∼13–17% counterbalanced by increases up to ∼9%. Higher household heating usage (+16–19% in March), also driven by colder weather conditions than 2019 (−0.2 to −0.8 °C) may partly explain primary PM emissions increase, while an increase in agriculture activities may account for the NH
3
emissions increase leading to secondary aerosol formation. This study confirmed the complex nature of atmospheric pollution even when a major emission source is clearly isolated and controlled, and the need for consistent decarbonisation efforts across all emission sectors to really improve air quality and public health.