Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass

Wang, Zhifa; Wang, Yunya; Han, Yuehu; Yin, Qiang; Hu, Sheng; Zhao, Ting; Chen, Tao; Ma, Heng; Gu, Chengxiong

doi:10.1016/j.lfs.2019.116734

Cited by 12 publications

(6 citation statements)

References 59 publications

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“…The absorption peak observed at 920.32 cm −1 was attributed to the β ‐type glycosidic bond 27 . The characteristic absorption peak of PSPP‐A observed at 830.54 cm −1 showed that PSPP‐A had an α ‐type glycosidic bond 28 . Finally, the peak at 535.91 cm −1 was attributed to the bending vibration of ‐OH out of plane 29 …”

Section: Resultsmentioning

confidence: 99%

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Extraction, purification, structural characterization, and hepatoprotective effect of the polysaccharide from purple sweet potato

Feng

et al. 2022

J Sci Food Agric

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BACKGROUND Purple sweet potato Ipomoea batatas (L.) has long been used as a medicine and a food. It contains various bioactive substances such as polysaccharides, anthocyanins, and flavonoids. Purple sweet potato polysaccharides are known to have anti‐oxidant, anti‐tumor, and immunomodulatory functions. Nevertheless, studies on the structural characterization of purple sweet potato polysaccharides and their ability to prevent non‐alcoholic fatty liver disease (NAFLD) have rarely been reported. RESULTS A novel polysaccharide (PSPP‐A) was extracted and isolated from purple sweet potato, and its structural characteristics and preventive effects on NAFLD were investigated. The results indicated that PSPP‐A was composed of l‐rhamnose, d‐arabinose, d‐galactose, d‐glucose, and d‐glucuronic acid with molar ratios of 1.89:8.45:1.95:1.13:1. Its molecular weight was 2.63 × 103 kDa. Methylation and nuclear magnetic resonance (NMR) analysis indicated that the glycosidic linkages were →3)‐α‐L‐Araf‐(1→, α‐L‐Araf‐(1→, →2,4)‐α‐L‐Rhap‐(1→, 4‐O‐Me‐β‐D‐GlcAp‐(1→, →4)‐α‐D‐Glcp‐(1→, →4)‐β‐D‐Galp‐(1→, and →6)‐β‐D‐Galp‐(1→. Scanning electron microscopy (SEM) indicated that the structure of PSPP‐A was irregular. Subsequently, the protective effect of PSPP‐A on NAFLD was investigated. The results indicated that bodyweight, liver index, and triglyceride (TG), total cholesterol (TC), aspartate transaminase (AST), and alanine transaminase (ALT) content were significantly reduced by intervention of purple sweet potato polysaccharide‐A (PSPP‐A) compared with the ‐ high‐fat diet group. Liver histopathological analysis indicated that PSPP‐A attenuated irregular hepatocyte patterns and excessive lipid vacuoles. CONCLUSIONS The novel polysaccharide, PSPP‐A, mainly contains arabinose, which has certain preventive effects on NAFLD. This study provides a theoretical basis for further elucidating the hepatoprotective effect of purple sweet potatoes as a functional food. © 2022 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

“…wileyonlinelibrary.com/jsfa glycosidic bond. 28 Finally, the peak at 535.91 cm −1 was attributed to the bending vibration of -OH out of plane. 29…”

Section: The Fourier-transform Infrared (Ftir) Analysis Of Pspp-amentioning

confidence: 98%

Extraction, purification, structural characterization, and hepatoprotective effect of the polysaccharide from purple sweet potato

Feng

et al. 2022

J Sci Food Agric

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“…state of IR, and the membrane glucose transportation and myocardial glucose uptake can be reduced. 34 Acute hyperglycemia and hyperinsulinemia can cause various synergistic effects for myocardium demand ischemia. Our present study demonstrated that both changes in CFV and changes in CFVR directly evaluated by transthoracic Doppler echocardiography during an OGTT were useful for elucidation of the association between acute hyperglycemia, hyperinsulinemia and coronary microvascular dysfunction.…”

Section: Advance Publicationmentioning

confidence: 99%

Association Between Insulin Resistance, Oxidative Stress, Sympathetic Activity and Coronary Microvascular Function in Patients With Early Stage Impaired Glucose Metabolism

Takei

Tomiyama

Tanaka

et al. 2022

Circ J

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“…In the case of insulin resistance, reduced IRS-1 tyrosine phosphorylation reduces the activation of PI3K-Akt signaling pathway and inhibits downstream insulin-mediated metabolic regulation 86 . The decrease of Akt phosphorylation directly leads to the decrease of GLUT4 translocation, which reduces the uptake of glucose in myocardium 86 87 . Reduced insulin signaling also inhibits glucose utilization by regulating the role of enzymes in the glycolysis pathway, such as hexokinase and phosphofructokinase 2 88 89 .…”

Section: Insulin Resistance and Cardiac Energy Metabolismmentioning

confidence: 99%

Effects of Lipid Overload on Heart in Metabolic Diseases

Xie

Ding

et al. 2021

Horm Metab Res

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Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed.

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Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass

Cited by 12 publications

References 59 publications

Extraction, purification, structural characterization, and hepatoprotective effect of the polysaccharide from purple sweet potato

Extraction, purification, structural characterization, and hepatoprotective effect of the polysaccharide from purple sweet potato

Association Between Insulin Resistance, Oxidative Stress, Sympathetic Activity and Coronary Microvascular Function in Patients With Early Stage Impaired Glucose Metabolism

Effects of Lipid Overload on Heart in Metabolic Diseases

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