Albendazole plus praziquantel versus albendazole alone as a pre‐operative treatment in intra‐abdominal hydatidosis caused by <i>Echinococcus granulosus</i>

Cobo, Francisco; Yárnoz, Concepción; Sesma, Benigno Ruíz; Fraile, Paula García; Aizcorbe, M.; Trujillo, R.; Diaz-de-Liaño, A; Ciga, M. A.

doi:10.1046/j.1365-3156.1998.00257.x

Cited by 146 publications

(124 citation statements)

References 16 publications

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“…[19][20][21][22] Over the past few decades, other anthelmintic chemotherapies such as praziquantel and nitazoxanide have also been tested against Echinococcus spp., but their efficacies are inferior to those of benzimidazoles. 16,23,24 Despite this, the combination of albendazole with praziquantel has shown synergistic activity against Echinococcus spp. In fact, observational studies suggest that the combined therapy could improve the cure rates obtained with albendazole alone [23][24][25][26] ; regarding the safety of medical therapy, an increase in transaminases levels is the most frequent adverse reaction related to albendazole treatment, 27 whereas digestive symptoms are the most frequent adverse effects associated with praziquantel in monotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…16,23,24 Despite this, the combination of albendazole with praziquantel has shown synergistic activity against Echinococcus spp. In fact, observational studies suggest that the combined therapy could improve the cure rates obtained with albendazole alone [23][24][25][26] ; regarding the safety of medical therapy, an increase in transaminases levels is the most frequent adverse reaction related to albendazole treatment, 27 whereas digestive symptoms are the most frequent adverse effects associated with praziquantel in monotherapy. Anaphylactic reactions related to praziquantel have also been described.…”

Section: Introductionmentioning

confidence: 99%

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Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease

Alvela-Suárez

Velasco‐Tirado

Belhassen-García³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and hydatid cyst size. When surgery is not possible, medical treatment is indicated. Traditionally, albendazole was used in monotherapy as the standard treatment. However, combined therapy with albendazole plus praziquantel appears to improve anti-parasitic effectiveness. To date, no safety studies focusing on such combined therapy have been published for the treatment of hydatidosis. In this work, we analyze the adverse effects seen in 57 patients diagnosed with hydatidosis who were treated with praziquantel plus albendazole combined therapy between 2006 and 2010.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease

Alvela-Suárez

Velasco‐Tirado

Belhassen-García³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…This indicates that the bioactive fraction in our crude extract might have some compound that has activity like pyrazinoisoquinoline derivative and selectively active on tegumental surface. In few of the recent studies, it was observed that praziquantel have substantial effect when used in combination of other scolicidal agents such as albendazole (Cobo et al 1998). Therefore, we speculate that our extract together with other synthetic drug/s might be more effective.…”

Section: Discussionmentioning

confidence: 76%

Osmoregulatory and tegumental ultrastructural damages to protoscoleces of hydatid cysts Echinococcus granulosus induced by fungal endophytes

2013

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Characteristic ultrastructural changes were observed when protoscoleces of hydatid cysts Echinococcus granulosus was treated with extract of endophytic fungi Eupenicillium and Chaetomium sp. isolated from Azadirachta indica and Piper longum plants respectively. A sharp decrease in viability of protoscoleces was observed after 6 h of incubation with fungal extracts. The ultrastructural changes included rosteller disorganization, loss of hooks and shedding of the microtriches of scolex region. The formation of digitiform projections on tegument layer which, increased in size as prolong incubation with extract and get burst, leading to a osmoregulatory damage into tegumental layers of parasite. This osmoregulatory damages caused the loss of turgidity due to leakage of cell contents, which might be the major cause of the mortality in treated parasites. It is remarkable, since very similar type of ultrastructural changes were observed with some pyrazinoisoquinoline derivatives, as praziquantel. Our initial results indicate that extract of endophytic Eupenicillium and Chaetomium spp. are having significant anti-cestodal activity and have selective activity on tegument layer. Further chemical prospection is required through rigorous bioassay guided fractionation coupled with robust high resolution mass spectrometric analysis to get final stereostructures responsible for the parasiticidal activity. This initial strain selection outcome will serve a platform for isolation and characterization of new drug lead that can be useful in tailoring novel, safe and effective anthelmintics.

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“…Moreover Albendazole at daily 40 mg/kg dose combined with another chemotherapeutic praziquantel for 1 week has been shown to be more effective than Albendazole alone [28].…”

Section: Treatmentmentioning

confidence: 99%

Uncomplicated Hydatid Cysts of the Liver: Clinical Presentation, Diagnosis and Treatment

Duman¹,

Gırgın²

2016

J Gastrointest Dig Syst

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Hydatid cyst of the liver is zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus and is still endemic in the South European regions, Asia, South America, North Africa, Australia, New Zealand and several Asian and European countries. The diagnosis of non complicated hydatid cyst of the liver depends on clinical suspicion. They appear in two ways as general (systemic) symptoms, and local symptoms based on the site and organ on which larva settles. While cysts sometimes recover spontaneously, more severe clinical presentations are observed in immunosuppressive individuals. Ultrasonography is the gold standard diagnostic tool and E. Granulosus antigen 5 (Ag5) and antigen B (Ag B) obtained from cyst fluid are used as a serologic diagnostic method in combination with the imaging method. The current treatment of hydatid cyst of the liver varies from surgical intervention to minimally invasive treatments (percutaneous drainage) or medical therapies. Surgery is still the best treatment tool. Percutaneous drainage and treatment of the cyst is a good option to surgery in selected cases. Multiple, superficial single cysts are the most suitable ones for surgical treatment. Also for complicated infected cysts pressing biliary tree and vital organs, surgery should be the first choice of treatment coming to mind. We believe that the laparoscopic approach should be safe to uncomplicated cysts. The purpose of our article is to provide a current review of clinical, diagnostic, and therapeutic features of hydrated cyst diseases.

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Albendazole plus praziquantel versus albendazole alone as a pre‐operative treatment in intra‐abdominal hydatidosis caused by Echinococcus granulosus

Abstract: Albendazole plus praziquantel is more effective than monotherapy with albendazole in the preoperative treatment of intra-abdominal hydatidosis.

Cited by 146 publications

References 16 publications

Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease

Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease

Osmoregulatory and tegumental ultrastructural damages to protoscoleces of hydatid cysts Echinococcus granulosus induced by fungal endophytes

Uncomplicated Hydatid Cysts of the Liver: Clinical Presentation, Diagnosis and Treatment

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