Albumin administration - what is the evidence of clinical benefit? A systematic review of randomized controlled trials

State of the art in fluid and volume therapy

“…Whether or not hypoalbuminemia was indeed the cause of the poor outcome or rather symptomatic of the severity of each particular disease (e. g., nutritional status, degree of inflammation) is still controversially discussed. However, in cases of severe hypoalbuminemia (<2.5 g/dl), there are many indications that albumin administration seems to be beneficial in terms of mortality, organ function, the amount of fluid to be applied (fluid balance), and tolerance of enteral nutrition [37][38][39][40][41]. The endothelial glycocalyx requires a low but nevertheless basal albumin concentration for maintenance of its barrier function.…”

Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

“…An oxidative stress resulting from an increased production of ROS, however, is relatively common finding in INS [8,9] though SBP develops only on rare occasions [1][2][3]. From the clinical point of view, it is interesting that hypoalbuminemia in INS is associated with a higher risk of development of SBP [2,3] and that an intravenous administration of human albumin preparations to the patients with SBP caused by liver cirrhosis may be beneficial [4,5]. These findings suggest an oxidative stress not only due to increased ROS but also due to decreased BAP is contributed to the development of SBP because an albumin, of which decreased serum level is hallmark of relapsing INS, is well-known antioxidant in vivo [6]: albumin is able to scavenge various strong oxidants compounds, such as hydroxyl radicals, peroxynitrite, and hypochlorous acid.…”

“…Hypoalbuminemia in INS is associated with a higher risk for development of SBP [2,3] and that an intravenous administration of human albumin preparations to the patients with SBP caused by liver cirrhosis may be beneficial [4,5]. Recent observation revealed that serum albumin plays an important role in the host defense mechanism as it is one of the important and of the most abundant antioxidants in vivo [6].…”

Fluid and Electrolyte Therapy in Cardiac Surgery

“…Hipotonik sıvılarla (yalnızca kristaloid) oluşturulan başlangıç solüsyonları kullanımında, genel olarak interstisyel sıvıda artış ve buna bağlı organ ödemleri görülebilmektedir (24,30) . Yalnızca kristaloid ile hazırlanan başlangıç solüsyonu kullanılan hastalarda postoperatif kilo artışları olurken, kristaloidlere kolloid de ilave edilerek başlangıç sıvısı hazırlandığında postop sıvı dengesindeki artışın azaldığı tespit edilmiştir (38,39) . Kristaloidlerin priming solüsyonu olarak daha yaygın kullanım nedeni, diüretik kullanımı ile atılımlarının kolay olmasından kaynaklanmaktadır.…”