Albumin/Procalcitonin Ratio Is a Sensitive Early Marker of Nosocomial Blood Stream Infection in Patients with Intra-Cerebral Hemorrhage

Deng, Shuixiang; Gao, Jiamin; Zhao, Zhiyong; Tian, Mi; Li, Yuming; Gong, Yi

doi:10.1089/sur.2018.260

Cited by 14 publications

(21 citation statements)

References 36 publications

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“…In ICH, serum PCT correlate with outcome, with higher PCR levels at admission being independently associated with unfavorable clinical outcome [ 100 ]. Another study combined albumin and PCT to uncover a ratio, where albumin/PCT ratio could be an additional diagnostic predictor for nosocomial infection in patients with ICH [ 101 ]. The role of PCT in CVT has not been investigated.…”

Section: Resultsmentioning

confidence: 99%

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

Dias

Azevedo

et al. 2021

Life

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Recent attention has been focused on the field of inflammatory biomarkers associated with vascular disorders, regarding diagnosis, prognosis, and possible therapeutical targets. In this study, we aimed to perform a comprehensive review of the literature regarding the use of inflammatory biomarkers in stroke patients. We searched studies that evaluated inflammation biomarkers associated with Cerebrovascular Disease (CVD), namely, ischemic Stroke (IS), Intracerebral Hemorrhage (ICH) and Cerebral Venous Thrombosis (CVT). As of today, neutrophil–lymphocyte ratio (NLR) seems the be the most widely studied and accepted biomarker for cerebrovascular disease due to its easy access and availability. Although demonstrated as a prognostic risk factor, in IS, ICH and CVT, its diagnostic role is still under investigation. Several other prognostic factors could be used or even combined together into a diagnostic or prognostic index. Multiple inflammatory biomarkers appear to be involved in IS, ICH, and CVT. Blood inflammatory cells, easily measured and accessible at admission may provide information regarding accurate diagnosis and prognosis. Although not yet a reality, increasing evidence exists to suggest that these may become potential therapeutic targets, likely influencing or mitigating complications of CVD and improving prognosis. Nevertheless, further larger, well-designed randomized clinical trials are still needed to follow up this hypothesis.

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Section: Resultsmentioning

confidence: 99%

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

Dias

Azevedo

et al. 2021

Life

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“…Studies have reported that PAR or ALB/PCT was an independent predictor of 28-day mortality in acute respiratory distress syndrome (ARDS) patients 43 and could be used as a sensitive early diagnostic marker for nosocomial blood stream infection in patients with intra-cerebral hemorrhage. 44 A low ALB/PCT ratio was associated with a high risk to experience shock in patients with intra-cerebral hemorrhage. 44 Luo et al 20 reported that PAR was an early diagnostic predictor that can discriminate between urosepsis and febrile urinary tract infection, and urosepsis patients with high PAR were more likely to experience uroseptic shock.…”

Section: Discussionmentioning

confidence: 98%

Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates

Liu

et al. 2022

JIR

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Purpose Previous studies have demonstrated that procalcitonin and albumin have a close correlation with sepsis. However, the role of procalcitonin (PCT) to albumin (ALB) ratio (PAR) in sepsis was still unclear, especially in neonates. Thus, this study aimed to investigate the association between PAR and neonatal sepsis. Patients and Methods A total of 1,196 neonates with suspected sepsis were included in this study. Neonates were divided into control group and sepsis group, according to whether they were diagnosed with sepsis. Neonates with sepsis were further divided into mild sepsis and severe sepsis group according to the severity of sepsis. PAR was calculated as serum PCT (ng/mL)/ALB (mg/mL). All statistical analyses were performed using the statistical package SPSS 24.0, as appropriate. Results Compared with the control group, neonates with sepsis had a higher PAR. PAR also showed a significant gradual increase in the control, mild sepsis, and severe sepsis groups ( P <0.001). Correlation analysis showed that there was a strong positive correlation between PAR and hsCRP, neonatal sequential organ failure assessment score (nSOFA), and prolonged length of hospital stay ( P <0.001). On multiple logistic regression, higher PAR was independently associated with the presence and severity of neonatal sepsis. According to the receiver operating characteristic curve analysis, a PAR ≥0.065 had 64% sensitivity and 72% specificity in predicting the presence of neonatal sepsis (area under curve (AUC)=0.72, 95% CI=0.69–0.75, P <0.001) and a PAR≥0.070 had 69% sensitivity and 63% specificity in predicting the presence of severe sepsis (AUC=0.71, 95% CI=0.68–0.74, P <0.001). Conclusion PAR is significantly higher in neonates with sepsis and correlated with the severity of the disease. Increased PAR is an independent predictor useful for identifying the presence and severity of neonatal sepsis.

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“…It is a cheap, easy-to-obtain, widely available clinical marker that can aid in the risk stratification of patients with various diseases ( 28 ). As a strong marker in diseases related to infection and inflammation, the ALB level usually decreases during the acute period ( 10 , 29 ). Miraeidi et al ( 12 ) reported that inflammation can lower ALB levels regardless of a patient's nutritional status.…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial dysfunction may also lead to impaired labyrinthine perfusion and reduced hearing capability in SSNHL patients ( 40 ). Finally, the ALB can elevate serum osmotic pressure, which attracts interstitial fluid and improves organ perfusion ( 29 ). Hearing recovery is thus facilitated by improved perfusion of the inner ear.…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study

et al. 2021

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Objectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL.Methods: A total of 135 SSNHL patients and 135 sex- and age-matched controls were prospectively enrolled. The baseline and clinical characteristics, along with liver function levels of participators, were collected. Linear correlation, logistic regression, and receiving operator characteristic curve analysis tests were applied to examine the association between liver function levels and SSNHL.Results: There were no differences in baseline characteristics between SSNHL and control groups. The albumin (ALB) level of the SSNHL group was significantly lower than that in the control group (p < 0.001). The logistic regression showed that the low ALB level may be a predictive factor of SSNHL with an adjusted OR of 0.809 (95% CI, 0.742–0.882, p < 0.001). By comparing the indicators of different prognosis groups, we found that the effective group had a significantly lower hearing impair onset and higher ALB (p = 0.001) and AGR (p = 0.003) levels than the ineffective group. Logistic regression revealed that the hearing level onset (OR, 0.976; 95% CI, 0.956–0.997; p = 0.026) and ALB level (OR, 1.181; 95% CI, 1.071–1.301; p = 0.001) showed strong associations with treatment outcome.Conclusions: Lower ALB levels, within the normal ranges, were associated with the occurrence and unfavorable outcome of SSNHL. However, further research on the underlying mechanisms needs to be conducted.

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Albumin/Procalcitonin Ratio Is a Sensitive Early Marker of Nosocomial Blood Stream Infection in Patients with Intra-Cerebral Hemorrhage

Cited by 14 publications

References 36 publications

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates

Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study

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