Alcohol consumption during gestation reduces the histamine and triiodothyronine content of rat immune cells

Csaba, G.; Kovács, P.; Pállinger, Éva

doi:10.1007/s00011-005-1366-5

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…Consequently, the durable unequivocal reduction of insulin binding of immune cells by occasional maternal alcohol consumption in the early pregnancy must be considered seriously. Earlier observations support this conclusion: serotonin [14] as well as histamine and triiodothyronine [15] content decreased in the adult animals after short alcohol exposition during early pregnancy. The results demonstrate that the encounter with minute doses of alcohol at the embryonal age can provoke not striking, however important disturbances manifested in adult age.…”

Section: Resultssupporting

confidence: 74%

Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Pállinger

Csaba

2005

Inflamm. res.

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Rat dams were exposed to 15% ethanol containing water ad libitum for 24 h at the 3rd day of gestation. Adult progenies' immune cells (peritoneal, blood and thymic lymphocytes, monocyte-macrophage-granulocyte group and mast cells) were studied by flow cytometry for binding of FITC-labelled insulin (compared to the appropriate cells of untreated animals). All of the cell types studied bound significantly less insulin, except mast cells. The results call attention to the life-long effect of occasional alcohol consumption in early pregnancy manifested in the immune system.

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Section: Resultssupporting

confidence: 74%

Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Pállinger

Csaba

2005

Inflamm. res.

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“…According to the literature, histamine concentration is 2.3 times the serotonin concentration in rat peritoneal fluid containing mast cells. 29 Thus, this CCD ion image sensor successfully detected both histamine and serotonin released from rat mast cells.…”

Section: ■ Results and Discussionmentioning

confidence: 88%

“…The most sensitive potential slope was obtained at 5% Na-TFPB, and this optimal membrane also responded to serotonin, showing a potential response about twice that with histamine. According to the literature, histamine concentration is 2.3 times the serotonin concentration in rat peritoneal fluid containing mast cells . Thus, this CCD ion image sensor successfully detected both histamine and serotonin released from rat mast cells.…”

Section: Results and Discussionmentioning

confidence: 99%

Two-Dimensional Microchemical Observation of Mast Cell Biogenic Amine Release as Monitored by a 128 × 128 Array-Type Charge-Coupled Device Ion Image Sensor

Hattori

Tamamura²,

Tokunaga³

et al. 2014

Anal. Chem.

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Available array-type, chemical-sensing image sensors generally only provide on/off responses to the sensed chemical and produce qualitative information. Therefore, there is a need for an array sensor design that can detect chemical concentration changes to produce quantitative, event-sensitive information. In this study, a 128 × 128 array-type image sensor was modified and applied to imaging of biogenic amines released from stimulated rat mast cells, providing recordable responses of the time course of their release and diffusion. The imaging tool was manufactured by an integrated circuit process, including complementary metal oxide semiconductor and charge-coupled device technology. It was fitted with an amine-sensitive membrane prepared from plasticized poly(vinyl chloride) including a hydrophobic anion, which allowed the sensor to detect amines, such as histamine and serotonin, in Tyrode's solution. As mast cells were larger in diameter than the pixel hollows, some pixels monitored amines released from single cells. The image from the array responses yielded sequential snapshots at a practical frame speed that followed amine concentration changes over time, after mast cell amine release was synchronized by chemical stimulation. This sensor was shown to be sensitive to amine release at very low stimulus concentrations and was able to detect localized spots of high amine release. The entire time course of the amine release was recorded, including maximum concentration at 4-6 s and signal disappearance at 30 s after stimulation. With further development, this sensor will increase opportunities to study a variety of biological systems, including neuronal chemical processes.

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“…We cannot give a clear‐cut explanation of the results as the functional role of nocistatin is still obscure. On the other hand there are several reports on the long‐term consequences of alcohol consumption, for example, a single 15% alcohol treatment during early gestation reduced histamine and triiodothyronine content (Csaba et al . 2005) and insulin binding (Pállinger & Csaba 2005) in the immune cells of adult animals.…”

Section: Resultsmentioning

confidence: 99%

“…Overlapping imprinting can be observed, when the perinatal effects (e.g. stress at weaning or alcohol during gestation) influence foreign molecules and functions especially when the imprinting mobilizes the whole endocrine system (Csaba, Kovács & Pállinger 2005).…”

Section: Introductionmentioning

confidence: 99%

PRECLINICAL STUDY: Perinatal alcohol exposure enhances nocistatin levels in adulthood

Tekes¹,

Hantos²,

Gyenge³

et al. 2007

Addiction Biology

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In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.

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Alcohol consumption during gestation reduces the histamine and triiodothyronine content of rat immune cells

Abstract: Since the immune system had not developed at the time of treatment (3rd day of pregnancy), stem cells were presumably imprinted. Our results indicate the deleterious effects of early maternal alcohol consumption on the hormone content of the immune system.

Cited by 3 publications

References 31 publications

Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Two-Dimensional Microchemical Observation of Mast Cell Biogenic Amine Release as Monitored by a 128 × 128 Array-Type Charge-Coupled Device Ion Image Sensor

PRECLINICAL STUDY: Perinatal alcohol exposure enhances nocistatin levels in adulthood

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