Alendronate-functionalized poly(amido amine) cryogels of high-toughness for biomedical applications

Guven, Melek Naz; Demirci, Gozde; Altuncu, Seckin; Gulyuz, Umit; Okay, Oğuz; Acar, Havva Yağcı; Avcı, Duygu

doi:10.1016/j.polymer.2020.122248

Cited by 13 publications

(15 citation statements)

References 68 publications

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“…The transient cryogel can then be photopolymerized to stabilize the structure, and the ice crystals are removed by thawing, leaving large interconnected macropores. Both the freezing rate and the temperature at which cryogels are formed influence the pore size. , Physical–chemical properties of the photopolymerized cryogels were reported, and in particular, swelling properties have been investigated. ,− It was shown that, due to higher porosity, cryogels swell more and faster than equivalent conventional hydrogels. Petrov et al tuned the degree of swelling with temperature by using thermoresponsive polymers in the cryogels.…”

Section: Strategies For Generating Porositymentioning

confidence: 99%

Photopolymerized Porous Hydrogels

Nicol

2021

Biomacromolecules

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Hydrogels are polymeric networks highly swollen with water. Because of their versatility and properties mimicking biological tissues, they are very interesting for biomedical applications. In this aim, the control of porosity is of crucial importance since it governs the transport properties and influences the fate of cells cultured onto or into the hydrogels. Among the techniques allowing for the elaboration of hydrogels, photopolymerization or photo-cross-linking are probably the most powerful and versatile synthetic routes. This Review aims at giving an overview of the literature dealing with photopolymerized hydrogels for which the generation or characterization of porosity is studied. First, the materials (polymers and photoinitiating systems) used for synthesizing hydrogels are presented. The different ways for generating porosity in the photopolymerized hydrogels are explained, and the characterization techniques allowing adequate study of the porosity are presented. Finally, some applications in the field of controlled release and tissue engineering are reviewed.

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Section: Strategies For Generating Porositymentioning

confidence: 99%

Photopolymerized Porous Hydrogels

Nicol

2021

Biomacromolecules

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“…Compression, tensile, and rheological studies have been widely used to determine the mechanical properties. 46,[85][86][87][88][89] For this study, compression tests were performed to analyze the viscoelastic behaviors of the control specimens and obtain the stress-strain curves (Figure 5). Although the compressive modulus alone does not directly inform about tensile performance, it is still consistent with the claim that AMP conjugation does not compromise the mechanical strength of the adhesive polymer.…”

Section: 66mentioning

confidence: 99%

Antimicrobial Peptide–Polymer Conjugates for Dentistry

Xie

Song

Yuca

et al. 2020

ACS Appl. Polym. Mater.

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Bacterial adhesion and growth at the composite/adhesive/tooth interface remain the primary cause of dental composite restoration failure. Early colonizers, including Streptococcus mutans, play a critical role in the formation of dental caries by creating an environment that reduces the adhesive's integrity. Subsequently, other bacterial species, biofilm formation, and lactic acid from S. mutans demineralize the adjoining tooth. Because of their broad spectrum of antibacterial activity and low risk for antibiotic resistance, antimicrobial peptides (AMPs) have received

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“…Aln is the most important anti-bone resorber for the treatment of bone diseases (Vasikaran, 2001;Rogers et al, 2015). Aln has a high affinity with bone minerals to prevent bone destruction by inhibiting osteoclast activity (Guven et al, 2020). We next evaluated the therapeutic potential of Gel+Mtx+Aln in vivo.…”

Section: Evaluation Of Anti-tumor Effects In Vivomentioning

confidence: 99%

Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

Shan

Zhao

et al. 2020

Front. Pharmacol.

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Osteosarcoma (OS) is a serious primary bone malignant tumor that can easily affect children and adolescents. Chemotherapy is one of the important and feasible clinical treatment strategies for the treatment of OS at present, which is severely limited due to insufficient retention time, poor penetration ability, and serious side effects of current antitumor drug preparations. In this work, a novel injectable thermo-sensitive hydrogel (mPEG 45-PLV 19) loaded with methotrexate and alendronate, and the sustained release at the tumor site synergistically inhibited the progression of OS. The mPEG 45-PLV 19 shows excellent physical and chemical properties. Compared with other treatment groups, the in vivo treatment of gel+ methotrexate + alendronate effectively inhibited the growth of tumor. More importantly, it significantly reduced bone destruction and lung metastasis caused by OS. Therefore, this injectable thermo-sensitive hydrogel drug delivery system has broad prospects for OS chemotherapy.

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Alendronate-functionalized poly(amido amine) cryogels of high-toughness for biomedical applications

Cited by 13 publications

References 68 publications

Photopolymerized Porous Hydrogels

Photopolymerized Porous Hydrogels

Antimicrobial Peptide–Polymer Conjugates for Dentistry

Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression

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