Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome

Chiu, Chui-De; Lee, Ming‐Huei; Chen, Wei-Chih; Ho, Hoi Lam; Wu, Huei-Ching

doi:10.1016/j.jpsychores.2017.06.019

Cited by 16 publications

(24 citation statements)

References 61 publications

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“…Further, our longitudinal assessment of bladder capacity across repeated procedures addresses the historical concern that post‐procedural scarring and fibrosis could lead to reduction in bladder capacity beyond that which might be inherent to the disease process. These results are consistent with other recent data suggesting that, similar to stratification of IC/BPS into ulcerative and non‐ulcerative subtypes, bladder capacity may be a unique marker of disease severity, prognosis, and comorbidity burden . The absence of development of new Hunner lesions in this cohort combined with anesthetic bladder capacities higher than what has been typically reported in the literature regarding ulcerative IC/BPS may also lend support to the idea that ulcerative and non‐ulcerative IC/BPS could be two distinct disease processes.…”

Section: Discussionsupporting

confidence: 92%

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Kirk

Santiago‐Lastra

Qin

et al. 2018

Neurourology and Urodynamics

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Section: Discussionsupporting

confidence: 92%

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Kirk

Santiago‐Lastra

Qin

et al. 2018

Neurourology and Urodynamics

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“…The rats also showed increased subepithelial MC infiltration and urinary NGF levels, 137,138 with increased engagement and connectivity of brain micturition neuronal circuits and motor cortex regions 135 . In addition, this WAS‐induced bladder hypersensitivity was exacerbated by early life stress, 139 which could mimic the potential relationship between childhood relational affect dysregulation and the development of IC/BPS without Hunner lesions in humans 140 . Interestingly, a recent study reported the potential link between WAS‐induced chronic stress and urothelial dysfunction, which was mediated by autonomic mechanisms and mitochondrial malfunction 137,141 .…”

Section: Animal Modelsmentioning

confidence: 92%

Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives

et al. 2020

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Abbreviations & Acronyms BPS = bladder pain syndrome CCL2 = C-C motif ligand 2 CNS = central nervous system DMSO = dimethyl sulfoxide EAC = experimental autoimmune cystitis ESSIC = International Society for the Study of BPS FSS = functional somatic syndrome GAG = glycosaminoglycan IC = interstitial cystitis IFN-c = interferon-gamma IL = interleukin MC = mast cell NGF = nerve growth factor OVA = ovalbumin TCR = T-cell receptor TNF = tumor necrosis factor TLR = Toll-like receptor UCPPS = urological chronic pelvic pain syndrome UPK = uroplakin Upo = unpublished observation VEGF = vascular endothelial growth factor WAS = water avoidance stress Correspondence: Yoshiyuki Abstract: Interstitial cystitis/bladder pain syndrome is a debilitating condition of unknown etiology characterized by persistent pelvic pain with lower urinary tract symptoms and comprises a wide variety of potentially clinically useful phenotypes with different possible etiologies. Current clinicopathological and genomic evidence suggests that interstitial cystitis/bladder pain syndrome should be categorized by the presence or absence of Hunner lesions, rather than by clinical phenotyping based on symptomatology. The Hunner lesion subtype is a distinct inflammatory disease with proven bladder etiology characterized by epithelial denudation and enhanced immune responses frequently accompanied by clonal expansion of infiltrating B cells, with potential engagement of infection. Meanwhile, the non-Hunner lesion subtype is a noninflammatory disorder with little evidence of bladder etiology. It is potentially associated with urothelial malfunction and neurophysiological dysfunction, and frequently presents with somatic and/or psychological symptoms, that commonly result in central nervous sensitization. Animal models of autoimmune cystitis and neurogenic sensitization might serve as disease models for the Hunner lesion and non-Hunner lesion subtypes, respectively. Here, we revisit the taxonomy of interstitial cystitis/bladder pain syndrome according to current research, and discuss its potential pathophysiology and representative animal models. Categorization of interstitial cystitis/bladder pain syndrome based on cystoscopy is mandatory to design optimized treatment and research strategies for each subtype. A tailored approach that specifically targets the characteristic inflammation and epithelial denudation for the Hunner lesion subtype, or the urothelial malfunction, sensitized/altered nervous system and psychosocial problems for the non-Hunner lesion subtype, is essential for better clinical management and research progress in this complex condition.

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“…For instance, sexual abuse exposure has been related to greater sensory pain and fewer urinary symptoms, although some report this relationship as modest. A recent study indicated that women exposed to trauma in childhood by close others had more anxiety, dissociative tendencies, and increased anesthetic bladder capacity, proposing that psychosocial factors may drive symptoms in this subset of patients …”

Section: Introductionmentioning

confidence: 99%

Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: Relationship to patient phenotype and clinical practice implications

McKernan

Johnson

Reynolds

et al. 2018

Neurourology and Urodynamics

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Purpose: The relationship between exposure to abuse and interstitial cystitis/bladder pain syndrome (IC/BPS) is well-documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. We aimed to assess the prevalence and impact of PTSD in patients with IC/BPS, including their relation to genitourinary symptom presentation and widespread pain phenotype. Materials and Methods: We recruited 202 participants with chronic pain from an academic medical center and classified 64 individuals as IC/BPS based on validated epidemiological criteria. Participants completed self-reported questionnaires assessing trauma exposure, PTSD symptoms, emotional distress, pain, and urinary symptoms. Wilcoxon rank-sum tests assessed study aims comparing IC/BPS to other chronic pain. Results: Although elevated, IC/BPS trauma exposure rates were equivalent to that of other chronic pain conditions in the sample. Despite this equivalence, in comparison, IC/BPS patients had significantly higher rates of PTSD symptoms, with 42% meeting provisional diagnostic criteria for PTSD. Among IC/BPS, those meeting provisional criteria for PTSD had significantly higher incidence of lifetime sexual abuse, childhood trauma, and presentations consistent with the widespread pain phenotype. In IC/BPS, there was no association between PTSD and genitourinary symptoms, but provisional PTSD was associated with more pain, emotional distress, and poorer quality of life. Conclusions: We recommend that patients with IC/BPS and widespread pain have ongoing screening and monitoring of PTSD. We recommend using trauma-informed care practices with these patients to increase trust and safety, which could improve treatment compliance and follow-up.

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Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome

Cited by 16 publications

References 61 publications

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives

Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: Relationship to patient phenotype and clinical practice implications

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