Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Boichenko, Alexander P.; Berthod, Alain

doi:10.1016/j.chroma.2010.07.001

Cited by 13 publications

(4 citation statements)

References 66 publications

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“…The use of hybrid micellar mobile phase (with organic modifier addition) leads to reduction in retention and sharpening of peaks. 13,14 In addition, the efficiency of the separation and peak asymmetry can be improved by using high temperatures due to faster mass transfer of solutes between mobile and stationary phases. 15 Preliminary experiments showed that the most appropriate temperature is 40 C.…”

Section: Resultsmentioning

confidence: 99%

“…It is well known that asymmetry of chromatographic peaks and efficiency of MLC separations could critically depend on the mobile phase composition due to changing of the kinetics of mass transfer in the presence of modifiers such as aliphatic alcohols or carboxylic acids. 9,[13][14][15] In the case of morphine, codeine, papaverine and noscapine separation the effect of modifiers on the efficiency of separation was quite pronounced, e.g. the next efficiencies obtained for the mobile phases contained 0.09 M SDS and 1.0, 2.0, 4.0 and 5.0% (v/v) 1-butanol: 3000, 3700, 3800, 4100 for morphine, and 1000, 1900, 1950, 2050 for papaverine.…”

Section: Optimization Of Chromatographic Conditionsmentioning

confidence: 99%

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Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

2011

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Micellar liquid chromatography (MLC) has been developed for the analysis of opium alkaloids. The composition of micellar mobile phase for the separation of morphine, codeine, papaverine and noscapine have been optimized by a chemometric tool taking into account the efficiency and asymmetry of chromatographic peaks, resolution between each pair of peaks and total time of separation. The optimized mobile phase composition (0.10 M sodium dodecylsulfate (SDS), 5% (v/v) 1butanol; pH 2.5) allows to fully separate alkaloids within 15 min. The proposed MLC method was validated, compared with the RP-HPLC method and successfully applied for the analysis of the pharmaceutical preparation ''Omnopon, solution for injection''.

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Section: Resultsmentioning

confidence: 99%

Section: Optimization Of Chromatographic Conditionsmentioning

confidence: 99%

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

2011

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“…Peak widths, asymmetries, and height ratios can all be considered when modifying the R S parameter. Some resolution should be lost in such optimizations to balance other needs 29 . Gradient elution is significant in chromatography of mixtures with widely varying polarities, such as drug analysis and the analysis of highly polar metabolites.…”

Section: Gradient Elutionmentioning

confidence: 99%

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2023

IJPSR

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The most commonly used analytical method in drug research is reversed-phase high-performance liquid chromatography (RP-HPLC). RP-HPLC methods also use huge quantities of solvents and generate by-products that must be disposed of, posing environmental and operator health worries. Micellar Liquid Chromatography (MLC) is a green chromatographic process for pharmaceutical analysis in which surfactants are applied above the Critical Micellar Concentration in the mobile phase (CMC). The ability of micelles to solubilize compounds that are not soluble or sparingly soluble in water is one of their properties; this property is critical for advancing analytical methods. MLC is also compliant with current RP-HPLC systems. As a result, no changes to the current RP-HPLC instrument are needed. MLC (micellar liquid chromatography) is a green and long-term method for analyzing medication compositions. MLC is not only the more environmentally friendly option, but it is also the more cost-effective. It is believed to have a mobile phase of 90% or more water (v/v), which can be recycled if injection volumes are small and far apart. The present review work will focus on analyzing and quantifying antiretroviral, anti-diabetic, antitumor, and cardiac drug formulations adapting the MLC method. INTRODUCTION:Micellar Liquid Chromatography (MLC) is a type of high-pressure liquid chromatography (HPLC) that uses micelles to separate molecules and in which the mobile phase contains an aqueous surfactant solution that is greater than the critical micellar concentration (CMC). Surfactants help modify internal interactions and decrease the quantity of organic solvent in the mobile phase that can be regenerated because of the high boiling point 1 .

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“…[4][5][6][7][8][9][10][11] Micellar liquid chromatography (MLC) method has been investigated as an interesting approach for green analytical chemistry (GAC), as it eliminates or reduces the use of organic solvents and uses mobile phases containing 90% (v/v) or more water. [12][13][14][15][16][17] MLC is attractive due to its lower cost, lower toxicity, greater stability, reduced negative impact on the environment and greater safety for laboratory use. MLC depends on using surfactants at a concentration above their critical micellar concentration (CMC).…”

Section: Introductionmentioning

confidence: 99%

Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities

Salkić,

Otašević,

Rašević

et al. 2023

ACSi

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A selective eco-friendly micellar HPLC method was developed for investigation of moxifloxacin and related compounds in the presence of its degradation products. Central composite design was used to optimize the experimental conditions. The proposed method is based on isocratic elution on a C18 column using 92.5% (v/v) biodegradable aqueous mobile phase containing 0.01 M sodium dihydrogen phosphate, 0.15 M sodium dodecyl sulfate (SDS) and 0.5% triethylamine (v/v) with a pH of 3.5 and 7.5% isopropanol (v/v) as eco- friendly organic solvent. The flow rate and injection volume were 0.6 ml/min and 5 μl, respectively. Experiments were performed at a temperature of 60 °C and detection was performed at 295 nm. The optimized method was validated. The method was found to be suitable for the quantification of moxifloxacin and its related compounds in moxifloxacin drug substance. The Green Analytical Procedure Index (GAPI) proves the superiority of the developed method against other reported methods.

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Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Cited by 13 publications

References 66 publications

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

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Micellar Liquid Chromatographic Method for Determination of Moxifloxacin and its Impurities

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