Alkali complexes of non-steroidal anti-inflammatory drugs inhibit lung and oral cancers in vitro

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain, fever, and inflammations. In this paper, we report four new alkali metal complexes (1 – 4) containing 1,10–phenanthroline (phen), and...

1D and 2D Coordination Polymers of Calcium with Nonsteroidal Anti‐Inflammatory Drugs: Synthesis, Crystal Structures, Hirshfeld Surfaces, Antimicrobial and Antioxidant Activities

“…[34] Moreover, coordination of the metal center or a metal-containing fragment to a biomolecule may prompt valuable antimicrobial, [35] anti-inflammatory, antioxidant [11,36] and anticancer [37] activities. Shan et al obtained alkaline earth metal complexes with diclofenac, [19] ibuprofen and flurbiprofen [20] with excellent anticancer activity against lung and oral cancer cell lines. In addition, Ali et al described zinc naproxen complex with significant activity against certain strains of Pseudomonas aeruginosa.…”

“…[2,7,[15][16][17][18] These metal ions play a crucial role in numerous biological pathways such as cellular diversity, partition, apoptosis, homeostasis, adjusting electrolyte balances, pH, and nerve impulses. [19,20] Additionally, they have an advantage over transition or lanthanide metal ions because most of the sblock cations are non-toxic, relatively cheap, and soluble in aqueous media. [21,22] Furthermore, their high coordination numbers increase coordination arrangements and prompt unusual supramolecular topologies.…”

“…However, significantly less attention has been paid to CPs based on the alkaline‐earth metal ions [2,7,15–18] . These metal ions play a crucial role in numerous biological pathways such as cellular diversity, partition, apoptosis, homeostasis, adjusting electrolyte balances, pH, and nerve impulses [19,20] . Additionally, they have an advantage over transition or lanthanide metal ions because most of the s‐block cations are non‐toxic, relatively cheap, and soluble in aqueous media [21,22] .…”

“…Shan et al. obtained alkaline earth metal complexes with diclofenac, [19] ibuprofen and flurbiprofen [20] with excellent anticancer activity against lung and oral cancer cell lines. In addition, Ali et al.…”