Alkaline phosphatase levels in canine mammary neoplasia

Hamilton, JM; Wright, J. L. W.; Kight, D

doi:10.1136/vr.93.5.121

Cited by 6 publications

(7 citation statements)

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“…Reference values: 24-129 U/l (mean ± SE: 63.5 ± 3.0 U/l). Hamilton et al (1973) reported significant increases of serum-ALP activity in a group of 21 dogs with benign (seven of 21) and malignant (14 of 21) mammary tumours, but no associations with malignancy or histological typing was attempted. The same investigators, however, also noticed that there was no precise correlation between tissue and serum-ALP activities.…”

Section: Discussionmentioning

confidence: 97%

“…Hamilton et al. (1973) reported significant increases of serum‐ALP activity in a group of 21 dogs with benign (seven of 21) and malignant (14 of 21) mammary tumours, but no associations with malignancy or histological typing was attempted.…”

Section: Discussionmentioning

confidence: 99%

“…The increased serum TALP in a certain number of canine mammary tumours could be the result of an exaggerated osteoblastic activity of neoplastic cells, leading to increased BALP production, as it has also been seen in some canine and human osteosarcomas and soft tissue sarcomas (Levine and Rosenberg, 1979; Leung et al., 1993; Yudoh et al., 1996; Ehrhart et al., 1998). Moreover, increased tissue‐ALP activities were found in the myoepithelial cells of both normal and neoplastic canine mammary glands (Hamilton et al., 1973; Tateyama and Cotchin, 1977). Therefore, increased serum TALP might also represent the local production of a new isoenzyme by tumour cells, similar to Regan‐isoenzyme in humans (Hamilton et al., 1973; Lehmann, 1975; Hoffmann, 1977; Larner and Rutherford, 1977; Mayne et al., 1987).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, increased tissue‐ALP activities were found in the myoepithelial cells of both normal and neoplastic canine mammary glands (Hamilton et al., 1973; Tateyama and Cotchin, 1977). Therefore, increased serum TALP might also represent the local production of a new isoenzyme by tumour cells, similar to Regan‐isoenzyme in humans (Hamilton et al., 1973; Lehmann, 1975; Hoffmann, 1977; Larner and Rutherford, 1977; Mayne et al., 1987).…”

Section: Introductionmentioning

confidence: 99%

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Total Serum Alkaline Phosphatase Activity in Dogs with Mammary Neoplasms: a Prospective Study on 79 Natural Cases

Karayannopoulou¹,

Koutinas²,

Polizopoulou³

et al. 2003

Journal of Veterinary Medicine Series A

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Increased total alkaline phosphatase (TALP) activity in the serum, long noticed in canine mammary tumours among other neoplasms, has not been yet associated with malignancy, osseous transformation of neoplastic tissue or histopathological typing. Therefore, the purpose of this study was to correlate this biochemical abnormality with the above-mentioned parameters, in 79 adult to elderly female dogs with mammary neoplasms, without evidence of metastatic or any other disease. Histopathology disclosed that 64 (81%) of these neoplasms were malignant and 15 (19%) benign, belonging to various histological types. Radiology and histopathology revealed the presence of osseous tissue in 18 (22.8%) cases. The malignant neoplasms were subsequently allocated into group A including 46 (74.2%) of epithelial origin and group B with 16 (25.8%) neoplasms of both epithelial and mesenchymal origin ('malignant mixed' tumours). In addition, their benign counterparts were divided into group C (adenomas, fibroadenomas) and group D (benign mixed tumours) that included seven (46.7%) and eight (53.3%) tumours, respectively. Almost 55% of the dogs with malignant and 47% with benign tumours had increased serum-TALP activity. However, no significant difference in serum-TALP activity was found between the dogs with malignant (mean +/- SE: 243.7 +/- 37.4 U/l) and benign (167.9 +/- 38.4 U/l) neoplasms, with (238.9 +/- 45.3 U/l) and without (226.5 +/- 38.3 U/l) osseous transformation, with (298.5 +/- 85.6 U/l) or without (201.2 +/- 30.5 U/l) myoepithelial cell proliferation and with different tumour size (T1/T2: 175.1 +/- 34.9 and T3: 254.5 +/- 42.5 U/l). In histopathological typing, the only difference noticed involved the malignant neoplasms of group A (190.5 +/- 25.5 U/l) compared with group B (378 +/- 124.6 U/l) dogs. The higher increase of serum-TALP activity in 'malignant mixed' tumours could not be attributed to osseous transformation or new ALP isoenzyme production by myoepithelial cells. Increased serum-TALP activity is of no apparent diagnostic (as to tumour type) or prognostic value.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Total Serum Alkaline Phosphatase Activity in Dogs with Mammary Neoplasms: a Prospective Study on 79 Natural Cases

Karayannopoulou¹,

Koutinas²,

Polizopoulou³

et al. 2003

Journal of Veterinary Medicine Series A

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“…[3][4][5] Increased serum TALP activity also has been observed in dogs with certain types of neoplasms, mainly bone and soft tissue sarcomas 6,7 and mammary gland tumors. 1,3,8,9 In the latter, the significantly higher serum TALP activity in dogs with malignant mixed (epithelial-mesenchymal) neoplasms compared to those with carcinomas could not be attributed to the osteoblastic activity of certain neoplastic cells of these tumors that eventually undergo osseous transformation. 9 However, in general, serum BALP has been considered a more specific indicator of osteoblastic activity and bone formation than serum TALP.…”

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confidence: 88%