Alkaloid compound identification of Rhodomyrtus tomentosa stem as biology instructional material for senior high school X grade

Ningrum, Retno; Purwanti, Elly; Sukarsono, Sukarsono

doi:10.22219/jpbi.v2i3.3863

Cited by 16 publications

(17 citation statements)

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“…Ligands are organic or inorganic compounds that play a role in interactions in the binding domain of proteins and can affect the activity of these proteins. Based onNingrum, Purwanti, & Sukarsono (2016), karamunting stems contain alkaloid-derived compounds, namely, Maritidine, Homolycorine, Lycorine, Ismine and Tazetine, where homolycorine and maritidine are ligands in large quantities (Ningrum, Purwanti, & Sukarsono, 2016). Ligands will be used for the anchoring process adjusted to human conditions, namely pH 7.4.…”

Section: Validation Of Alkaloid Derivative Compoundsmentioning

confidence: 99%

“…One of the plants used as traditional medicine by the people of Kalimantan is karamunting (Rhodomyrtus tomentosa). This plant belongs to the Myrtaceae family and has the international name Rosemyrle (Ningrum, Purwanti, & Sukarsono, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Still, some alkaloid compounds are toxic, so it is necessary to identify alkaloid compounds whose benefits can be known. Furthermore, Ningrum, Purwanti, & Sukarsono (2016) research showed that the alkaloids found in the karamunting plant were Maritidine, Homolycorine, Ismine, Tazettine, and Lycorine (Ningrum et al, 2016). α-Glucosidase inhibitor is a type of drug for type 2 diabetes that works to block starch metabolism by inhibiting enzymes in the intestine to break down carbohydrates to slow down glucose absorption (Ak, Juliani, Sugito, & Abrar, 2019;Laily & Khoiri, 2016;Ouassou et al, 2018;Yin, Zhang, Feng, Zhang, & Kang, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa)Against α-Glucosidase Enzymes

Mulyati

Panjaitan

2021

Indo. J. Chem. Res.

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Karamunting plant (Rhodomyrtus tomentosa) is a traditional medicinal plant. The leaves, roots, stems, and fruits of Karamunting have been identified, and their biological activities are antioxidants, antibacterial, antidiabetic, anti-inflammatory, and anticancer that contained alkaloids, tannins, and flavonoids. The types of alkaloids found in karamunting stems are homolycorine, ismine, lycorine, maritidine and tazetine. This study aims to determine the binding score of alkaloid-derived compounds with protein α-glucosidase and determine the protein's active site bound to the ligand. The method used in this research is Protein-Ligand ANT-System (PLANTS). The results showed that the anchoring score of homolycorine was -60.83 kcal/mol, ismine -64.42 kcal/mol, lycorine -71.20 kcal/mol, maritidine -61.82 kcal/mol, and tazetine -65.02 kcal/mol. The active sites used for binding are Glu526, Gly555, and Pro556. The average score for anchoring alkaloid-derived compounds with protein α-glucosidase is 83.84%. This number indicates that karamunting stems can be used as antidiabetic.

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Section: Validation Of Alkaloid Derivative Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa)Against α-Glucosidase Enzymes

Mulyati

Panjaitan

2021

Indo. J. Chem. Res.

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“…Alkaloid merupakan kelompok terbesar dari metabolit sekunder dan sebagian besar bersumber pada tumbuhan, namun sebagian juga dapat ditemui pada bakteri (Ningrum et al, 2016). Senyawa alkaloid terdapat gugus basa yang mengandung nitrogen akan bereaksi dengan senyawa asam amino yang menyusun dinding sel bakteri dan DNA bakteri.…”

Section: Prosedur Penelitianunclassified

EFEKTIVITAS BERBAGAI KONSENTRASI EKSTRAK DAUN KAYU MANIS (Cinnamomum burmannii [Ness.] BI) TERHADAP DIAMETER ZONA HAMBAT PERTUMBUHAN BAKTERI Staphylococcus epidermidis

Qomar¹,

Budiyanto

Sukarsono

et al. 2018

Biota

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Staphylococcus epidermidis is one of the bacteria that can cause infectious diseases. In general Staphylococcus epidermidis can cause diseases of swelling (abscess) such as skin infections or acne. Cinnamon (Cinnamomum burmannii [Ness.] BI) leaf extract has a substance which gives antimicrobial effects that can be used as an inhibitor of the Staphylococcus epidermidis bacteria’s growth because it contains substances such as essential oils, flavonoids, saponins, tannins, and alkaloids. The aim of this research is to analyse the effect of the concentration of cinnamon leaf extract and to determine the concentration of extract which has the best influence to the inhibition zone diameter of Staphylococcus epidermidis bacteria. This research was conducted in Biology Laboratory of University of Muhammadiyah Malang, on 17-18 May 2017. The results showed that there was an effect of giving various concentrations of cinnamon leaf extract to the inhibition zone diameter of Staphylococcus epidermidis bacteria’s growth. The concentration of cinnamon leaf extract which has the best influence to the inhibitory zone diameter of Staphylococcus epidermidis bacteria is 100% with the mean of inhibitory zone diameter 15.16 mm.

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“…Adanya senyawa antioksidan menyebabkan perubahan warna violet menjadi kuning, karena semakin kuat senyawa antioksidan, makin jelas perubahan warna yang terjadi (Pisoschi, 2009). Faktor suhu memberikan pengaruh terhadap senyawa fenolik (Ningrum et al, 2016). Suhu yang terlalu lama akan mengakibatkan terjadinya pemaparan O2 semakin banyak, sementara terdapat beberapa komponen fenol yang bersifat termosensitif.…”

Section: Pembahasanunclassified

Kualitas Minuman Herbal Kulit Pisang Raja Bulu (Musa paradisiaca L.) pada Suhu Pengeringan Berbeda

et al. 2017

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Banana peels have not been utilized optimally, just disposed of as organic waste or used as animal feed. Ripe banana peel skin is rich of chemical compounds which are antioxidants, both flavonoid compounds and other phenolic compounds. Banana peel contains high antioxidant activity compared to meat, especially "Raja Bulu" banana skin which has antioxidant equal to 97,85%. Natural source of antioxidants in banana peel skin is very beneficial for health. The purpose of this study was to determine the effect of various drying temperature on antioxidant activity and the optimum drying temperature to antioxidant activity. This study also aims to determine the level of panelist's preference for herbal drinks of "Raja Bulu" banana peel with various drying temperatures. The type of research used is True Experimental Research. The study design was using RAL with 4 treatment P0 (control), P1 (drying temperature 75°C), P2 (drying temperature 80°C), P3 (drying temperature 85°C). Data is included the amount of antioxidant activity content and the average of organoleptic properties of banana peel herbal drink. Data analysis techniques used are One Way Anova and qualitative descriptive. The results showed 1) Various drying temperature effect on the antioxidant activity of banana peel herbal drink. 2) The best treatment is P3 (drying temperature 85°C) with antioxidant activity of 84,87%.3) The result of the panelist's favorite test for the best color, flavor and taste on P3 treatment with 85°C drying temperature.

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Alkaloid compound identification of Rhodomyrtus tomentosa stem as biology instructional material for senior high school X grade

Cited by 16 publications

References 2 publications

Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa)Against α-Glucosidase Enzymes

Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa)Against α-Glucosidase Enzymes

EFEKTIVITAS BERBAGAI KONSENTRASI EKSTRAK DAUN KAYU MANIS (Cinnamomum burmannii [Ness.] BI) TERHADAP DIAMETER ZONA HAMBAT PERTUMBUHAN BAKTERI Staphylococcus epidermidis

Kualitas Minuman Herbal Kulit Pisang Raja Bulu (Musa paradisiaca L.) pada Suhu Pengeringan Berbeda

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