Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential

Ravanelli, N.; Santos, Kátia Pereira dos; Motta, Lucimar Barbosa; Lago, João Henrique G.; Furlan, Cláudia Maria

doi:10.1016/j.sajb.2015.06.011

Cited by 26 publications

(18 citation statements)

References 25 publications

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“…Bisbenzylisoquinoline alkaloids are also found in the genus Stephania. In 2014, two new compounds, (−)pseudocurine (55) and (−)-pseudoisocurine (56), were isolated from a leaf extract of Stephania abyssinica. 48 Tetrandrine (57) and fangchinoline (58) were isolated from Stephania tetrandra, which has been used for 2000 years as an antirheumatic herbal medicine in China.…”

Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

“…infectoria, and C. griffithiana. 37 Corydine (90) and norisoboldine (91) were isolated from Croton echinocarpus leaves, 55 while isocorydine (92) and norisocorydine (93) were identified from A. corneri 52 ( Figure 5).…”

Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning

confidence: 99%

“…Corydine(90)and norisoboldine(91), aporphine alkaloids from Croton echinocarpus leaves, displayed significant in vitro anti-HIV potential. The latter compound more potently inhibited HIV-1 reverse transcriptase enzyme activity 55. Several michellamine-type dimeric naphthylisoquinoline alkaloids inhibited replication of HIV reference…”

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confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

146

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

146

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“…showing anti-HIV activity [189]. Table 2 depicts the plant based alkaloids possessing anti-HIV activity.…”

Section: Natural Plants As Protease Inhibitorsmentioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Kaur

Sharma

Gupta³

et al. 2020

Preprint

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Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.

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“…Chemically, Croton stands out for the production of diterpenes (MACIEL et al, 2006;PIZZOLATTI et al, 2013). Other secondary metabolites include triterpenes, flavonoids, alkaloids and phenylpropanoids (CANELO et al, 2017;SANTOS et al, 2015;RAVANELLI et al, 2016;ALVES et al;. A broad biological action is attributed to these metabolites and to extracts and/or fractions obtained from species of the genus, such as antioxidant, cytotoxic, mutagenic and antimicrobial activities (AQUINO et al, 2017;SANTOS et al, 2015;ALMEIDA et al, 2019).…”

Section: Introductionmentioning

confidence: 99%