All-polysaccharide hydrogels for drug delivery applications: Tunable chitosan beads surfaces via physical or chemical interactions, using oxidized pullulan

Duceac, Ioana A.; Vereştiuc, Liliana; Coroabă, Adina; Arotăriței, Dragoș; Coseri, Sergiu

doi:10.1016/j.ijbiomac.2021.04.128

Cited by 43 publications

(22 citation statements)

References 61 publications

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“…Polymeric materials processed in the form of cryogels can be obtained by various strategies. Physical and chemical cross-links have been explored in the literature with significant success in finely tuning network parameters and properties [ 28 ]. In this context, we hypothesized that stable networks can be obtained by combining dialdehyde pullulan and dopamine, aiming to create a material suitable for dressing in the management of bleeding wounds.…”

Section: Resultsmentioning

confidence: 99%

“…Given the experience of our research group in obtaining polysaccharides functionalized using selective oxidation methods, particularly pullulan, and their further use for preparing hydrogels [ 22 , 28 , 29 , 30 ], we propose in this study a new polymeric system. We hypothesized that periodate-oxidized pullulan can form stable hydrogels based on (hemi)acetal bonds and additional dopamine can be incorporated with success by interacting with the aldehyde groups, improving the stability of the networks.…”

Section: Introductionmentioning

confidence: 99%

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Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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“…For drug-loaded hydrogel system, the drug release is determined by the interactions between the drug and the hydrogel, the ratio of drug diffusion, the loading of drug, and stability and biodegradation of the hydrogel. 45 The triggered release of drugs from hydrogels combined with a controlled release ratio are important functions of drug-loaded hydrogels. 46 Fig.…”

Section: Release Of Tannic Acidmentioning

confidence: 99%

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Cheng

Peng

Xi³

et al. 2022

Food Funct.

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“…Chitosan hydrogels are mostly dedicated to skin wound healing [252][253][254][255][256][257][258][259], but also find application as biomaterial applied to bone regeneration [260], spinal cord regeneration [261] or heart disease [262].…”

Section: Hydrogelsmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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All-polysaccharide hydrogels for drug delivery applications: Tunable chitosan beads surfaces via physical or chemical interactions, using oxidized pullulan

Cited by 43 publications

References 61 publications

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Chitosan as an Underrated Polymer in Modern Tissue Engineering

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