Allergic contact dermatitis caused by glycyrrhetinic acid and castor oil

Allergic contact dermatitis caused by aftershave creams containing Glycyrrhiza inflata

“…They are probably only poorly absorbed through the (intact) skin, and they are considered to be relatively safe, that is, without obvious irritant or (photo‐)sensitizing properties . Interestingly, weaker reactions to higher concentrations of the steroid‐like enoxolone have been observed during patch testing, which (similarly to the situation with corticosteroids) may be attributable to a dominating anti‐inflammatory effect . A summary of previously published cases of allergic contact dermatitis caused by liquorice derivatives is given in Table S1 ().…”

“…glabridin), whereas water‐soluble (dry) extracts typically contain saponins such as glycyrrhizin, a mixture of potassium and calcium salts of 18β‐glycyrrhizic acid (glycyrrhizate), which may be hydrolysed to form 18β‐glycyrrhetinic acid (syn. glycyrrhizinate; enoxolone) (). Enoxolone possesses (mild) anti‐inflammatory properties, which is why it has been included in a medical specialty to treat atopic and allergic contact dermatitis (Atopiclair®; Graceway Pharmaceuticals, Bristol, TN, USA) .…”

Contact Allergy to Castor Oil, but Not to Castor Wax

“…Cases of allergic contact dermatitis from the oil, and from its derivatives, have occasionally been reported [5][6][7]. We here report 2 additional cases of allergic contact dermatitis from castor oil present in lip balms, whereas patch tests with hydrogenated castor oil 30% in petrolatum (pet.)…”

Allergic contact dermatitis caused by arbutin and dipotassium glycyrrhizate in skin‐lightening products

“…Cases of allergic reactions to extracts from Glycyrrhiza spp. root have been reported (3,(5)(6)(7)(8)(9)(10)(11).…”