Allergic contact dermatitis from para‐nitrobenzyl bromide

Airborne allergic contact dermatitis from 4‐(bromomethyl)benzoic acid in a university chemist

“…Bromine is a highly reactive halogen, which may cause irritation too. A facial dermatitis was recently reported from 4‐nitrobenzyl bromide, closely resembling 4‐(bromomethyl)benzoic acid (2) (Fig. 1).…”

“…Airborne contact dermatitis caused by powdered or volatile chemicals has been described in chemistry workers (1–3). Chemists are often exposed to multiple chemicals, and complete avoidance may be difficult.…”

Contact dermatitis caused by bromide compounds

“…Although rare, contact dermatitis caused by bromide products such as p ‐nitrobenzyl bromide has been reported ; however, the mechanisms involved have not been evaluated. Here, we found T cell involvement, mainly in the skin, of both CD4 and CD8 cells, with expression of the activation marker HLA‐DR, the memory marker CD45RO, and the homing receptor CLA, a pattern similar to that detected in delayed hypersensitivity reactions to drugs .…”

“…At T2, skin patch testing at 0.1% wt/wt in pet. was performed as previously described , with 4‐carboxybenzyl(triphenyl)phosphonium bromide (CAS no. 17814‐85‐6), N ‐bromosuccinimide (CAS no.…”

Occupational airborne contact dermatitis caused by trifluoroacetic acid in an organic chemistry laboratory

“…Chemists and technicians are exposed to various chemicals. Airborne contact dermatitis caused by volatile chemicals has been shown (). We report a case of airborne allergic contact dermatitis caused by trifluoroacetic acid (TFA) in a laboratory technician.…”