Allergic contact dermatitis in patients with leg ulcers

Marasović, Dujomir; Vuksić, I

doi:10.1111/j.1600-0536.1999.tb06242.x

Cited by 29 publications

(20 citation statements)

References 34 publications

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“…Together with the antimicrobials, our study clearly shows the importance of TTCM as contact allergens in our group of patients with chronic venous leg ulcers. The overall sensitization rate of 61.4% was in agreement with studies from previous centres (2–7).…”

Section: Discussionsupporting

confidence: 91%

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Contact sensitization in patients with chronic venous leg ulcers in Singapore

et al. 2007

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Contact sensitization rates are high in patients with chronic venous leg ulcers. Allergic contact dermatitis poses a significant hindrance to the healing of the wounds. There are no published studies examining the rate of contact sensitization in Asian patients. Our objective was to determine the rate of contact sensitization in patients with chronic venous leg ulcer in Singapore and the variation in the common allergens based on local practices in comparison with Western countries. 44 patients were patch tested to the National Skin Centre standard series, steroid series, medicaments, topical Chinese medicaments, and to modern wound dressings used. The overall rate of contact sensitization was 61.4%. The common allergen groups were topical antibiotics (18.2%) and topical traditional Chinese medicaments (TTCM) (15.9%). Individually, colophony (11.3%), Saw Hong Choon skin ointment (Kam Bo Med, Hong Kong, Hong Kong) (11.3%), Balsam of Peru (9.1%), and povidone iodine (9.1%) were among the most frequent allergens. The sensitization rate among users of TTCM was notably high (41%). A high rate of contact sensitization was found in our study, similar to previous reports from the West. TTCM play a major role as possible allergens in our patients. In Asian patients, a history of its usage should be elicited, and patch testing should include the commonly used TTCM where possible.

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Section: Discussionsupporting

confidence: 91%

“…The higher sensitization rate for flavine (6.8%) may be due to exposure to over the counter medicaments containing the compound by patients. Povidone iodine is a rare sensitizer, but has been reported in patients suffering from stasis eczema (4, 19). In our study, povidone iodine tested as is may be an irritant.…”

Section: Discussionmentioning

confidence: 60%

Contact sensitization in patients with chronic venous leg ulcers in Singapore

et al. 2007

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“…Allergic contact dermatitis coexisting with CVLU creates a difficult clinical problem from both diagnostic and therapeutic standpoint. It affects up to 60-85% of patients with CVLU (10)(11)(12)(13)(14)(15)(16)(17)(18). The most common contact allergens found in the CVLU patients are balsam of Peru, fragrances mix, neomycin, gentamycin, glucocorticosteroids and lanolin (10, 12-15, 17, 19, 20).…”

mentioning

confidence: 98%

Contact allergy in patients with chronic venous leg ulcers – possible role of chronic venous insufficiency

Żmudzińska¹,

Czarnecka‐Operacz

Silny³

et al. 2006

Contact Dermatitis

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The purpose of this study was to evaluate frequency of contact allergy in patients with chronic venous leg ulcers (CVLU) and to estimate possible relationships between allergic contact reactions and characteristics of both chronic venous insufficiency (CVI) and CVLU. We performed patch tests with the European standard series, antibiotics, glucocorticosteroids and ointment vehicles in 50 patients with CVLU. Patients underwent detailed CVI diagnostics using colour flow duplex ultrasound examination, ankle brachial pressure index determination and leg ulcers area measurement. Positive patch tests results were found in 80% and polyvalent allergy in 56% of patients. Statistically significant correlations were recorded between CVI and CVLU duration, CVLU duration and CVLU area and between CVI duration and polyvalent allergy frequency. Statistically significant differences were observed between coexistence of superficial and deep system insufficiency and CVLU duration, characteristics of contact allergic reactions and CVI duration, frequency of allergic contact reaction and presence or absence of long saphenous vein insufficiency, incidences of vein thrombosis and characteristics of contact allergic reactions as well as between characteristics of contact allergic reactions and both CVLU duration and area. Complex pathophysiological processes, including inflammatory reactions, in course of CVI may influence development of allergic contact reaction in CVLU patients.

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“…[2][3][4][5][6] This is particularly important, as there have been numerous reports in the literature of allergic reactions to various ingredients used in cosmetic products and some topical medications. [7][8][9][10][11][12] To minimize this risk, the excipients of the emollient should be selected with the greatest care. Ingredients that are known or even highly suspected to cause irritation or sensitization (e.g.…”

Section: Choice Of Ingredientsmentioning

confidence: 99%

Is there room for improvement in the emollients for adjuvant therapy?

Trapp¹

2007

Acad Dermatol Venereol

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Emollients play an important part in the management of patients with dry skin disorders, such as atopy, allergy, eczema, psoriasis or dryness following chemotherapy or radiotherapy. Their use in the treatment of diseased and sensitive skin requires not only an efficient hydrating and lipid-replenishing effect on the skin, but minimal risk for skin irritation or sensitization. This will be influenced by their formulation and number and type of ingredients and, due to the nature of their application, requires clinical testing to ensure their appropriateness for dermatological rather than cosmetic use. A new generation of emollients has been developed for the care of dry, or very dry, and sensitive skin. Among these, Dardia Lipo Line (Intendis GmbH, Berlin, Germany) has been formulated specifically for use in post-therapy preventive skin care. The current clinical evidence for this line of emollients is reviewed here.

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Allergic contact dermatitis in patients with leg ulcers

Cited by 29 publications

References 34 publications

Contact sensitization in patients with chronic venous leg ulcers in Singapore

Contact sensitization in patients with chronic venous leg ulcers in Singapore

Contact allergy in patients with chronic venous leg ulcers – possible role of chronic venous insufficiency

Is there room for improvement in the emollients for adjuvant therapy?

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