Allergic reactions to drugs: current concepts and problems

Coleman, JW

doi:10.1111/j.1365-2222.1990.tb02779.x

Cited by 12 publications

(7 citation statements)

References 51 publications

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“…The ability of T-cells to recognize small (haptenic) molecules raises questions of importance both to our understanding of fundamental immunology and to our ability to treat patients suffering from allergic responses to drugs and other haptens. For drug allergens that are not peptide in nature, the molecular conformation of the epitopes recognized by T-cells remains unclear, although there is convincing evidence that T-cells are capable of recognizing many small molecules, ranging from metal ions such as Ni2+, drugs such as penicillamine, and experimental haptens such as trinitrophenol and oxazolone (62)(63)(64). In some cases, conjugation of drug to carrier proteins, followed by conventional processing and presentation by MHC class I1 molecules, may be implicated (63,64) whereas in others there is no convincing evidence yet that carrier proteins are involved (63).…”

Section: Drugs and T-cell Responsesmentioning

confidence: 99%

Structure-Activity Studies on Drug-Induced Anaphylactic Reactions

Baldo

Pham²

1994

Chem. Res. Toxicol.

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As a result of recent research and development, an expanding range of in vitro assays for the detection of drug-reactive IgE antibodies is now available for the diagnosis of individual drug allergies. Continuing immunochemical studies on drugs implicated in allergic reactions via further development of specific immunoassays and production of drug-protein conjugates will allow us to build up a picture of the repertoire of drug and drug-derived B-cell allergenic determinant structures and to identify and predict cross-reactivities. Although we have made good progress in identifying some drug B-cell determinants, we remain ignorant of drug T-cell determinants and, indeed, of the nature of T-cell recognition of all nonpeptide molecules. Demonstration that drugs specifically recognize T-cells from drug-allergic patients may reveal associations with HLA phenotypes, the nature and location of interaction between drug and MHC molecules, and the nature and identity of drug or drug-derived T-cell antigens. A knowledge of the molecular nature of T-cell determinants inducing allergic responses is fundamental to therapeutic attempts to modulate these deleterious reactions. The possibility now exists for the allergenic screening of drugs as part of their toxicological evaluation, and identification of allergenic structures on drugs also has implications for the testing of allergenic activity and sensitizing potential of other chemicals in our environment. Obvious and important areas for the application of our methods and findings are the pharmaceutical and cosmetic industries.

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Section: Drugs and T-cell Responsesmentioning

confidence: 99%

Structure-Activity Studies on Drug-Induced Anaphylactic Reactions

Baldo

Pham²

1994

Chem. Res. Toxicol.

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“…Amoxicillin is a zwitterionic molecule that has a primary amine group, giving it strong reactivity with nucleophilic centers. Haptenation of AMX occurs by nucleophilic opening of the β‐lactam ring; with Lys, Cys, and His residues particularly being the major nucleophilic sites that covalently react with this ring, leading to formation of the amoxicilloic‐protein adduct which may elicit an immune hypersensitivity response (Weck, ; Lafaye and Lapresle, ; Coleman, ; Silvio et al, ; Gleichmann, ; Ariza et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid

Elizalde-Velázquez

Martínez-Rodríguez

Galár-Martínez

et al. 2016

Environmental Toxicology

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Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad-spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, there is not enough information on its potential toxicity to aquatic organisms such as the common carp Cyprinus carpio. This study aimed to evaluate AMX-induced oxidative stress in brain, gill, liver and kidney of C. carpio. Carp were exposed to three different concentrations of AMX (10 ng/L, 10 μg/L, 10 mg/L) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC), protein carbonyl content (PCC) and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Amoxicillin and its main degradation product amoxicilloic acid (AMA) were determined by high performance liquid chromatography coupled with electrochemical detection and UV detection (HPLC-EC-UV). Significant increases in LPX, HPC, and PCC (P < 0.05) were found in all study organs, particularly kidney, as well as significant changes in antioxidant enzymes activity. Amoxicilloic acid in water is concluded to induce oxidative stress in C. carpio, this damage being highest in kidney. The biomarkers used are effective for the assessment of the environmental impact of this agent on aquatic species. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1102-1120, 2017.

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“…Immunotoxic reactions induced by drugs such as penicillins, cephalosporins, sulfonamides, insulin and streptokinases are often caused by specific IgE responses (1, 2). The reactions range from those which are relatively mild to those that are life threatening.…”

Section: Discussionmentioning

confidence: 99%

“…IgE‐mediated allergic reactions to a wide range of drugs are relatively rare but nevertheless represent a serious clinical problem (1, 2). Currently there are no tests that are predictive either of the capacity of novel compounds to induce IgE‐mediated allergic reactions, or of the susceptibility of individuals to experience allergic reactions.…”

mentioning

confidence: 99%

“…In the first system, human peripheral lymphocytes (PBL) from normal donors were stimulated with anti‐CD3 activated T cells and the secretion of specific IgE antibodies from the cells stimulated with or without the allergen was analyzed in ELISA. In this system we selected the allergen β‐lactam antibiotic benzylpenicillin (BP) that induces IgE responses in some individuals and occasional anaphylaxis (1, 2, 10, 11) and a protein allergen, the common environmental grass pollen Phlenum pratense (PP). We compared the in vitro IgE responses to these allergens with the previously well‐characterized in vitro IgG response to the nonallergenic antigen TT, tetanus toxoid (12).…”

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confidence: 99%

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