Alloantibodies against low‐frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases

Ghevaert, Cédric; Rankin, Angela; Huiskes, Elly; Porcelijn, Leendert; Javela, Kaija; Kekomäki, Riitta; Bakchoul, Tamam; Nutland, Sarah; Smyth, Deborah J.; Smith, Graham; McBride, Simon; Watkins, Nicholas A.; Ouwehand, Willem H.

doi:10.1111/j.1537-2995.2009.02246.x

Cited by 35 publications

(39 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the only previously reported study of this type, Ghevaert and colleagues determined the prevalence of 11 LFHPAs in 1054 fathers of suspected NAIT cases, 831 of which could not be accounted for by maternal antibodies against common HPA antigens. Eight fathers were positive for the antigens HPA‐6bw (four cases), HPA‐10bw (one case), HPA‐11bw (one case), and HPA‐12bw (two cases).…”

Section: Discussionmentioning

confidence: 99%

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

et al. 2013

View full text Add to dashboard Cite

Background Twenty-four low frequency platelet antigens (HPAs) have been implicated as immunogens in neonatal alloimmune thrombocytopenia (NAIT). We performed studies to define more fully how often these antigens trigger maternal immunization leading to NAIT. Study design and methods In a Phase 1 study, fathers of selected NAIT cases not resolved by serologic testing but thought to have a high likelihood of NAIT on clinical and serologic grounds were typed for low frequency HPAs (LFHPAs) by DNA sequencing. In a Phase 2 study, high-throughput methods were used to type fathers of 1067 consecutive unresolved NAIT cases for LFHPAs. Mothers of 1338 unresolved cases were also typed to assess the prevalence of LFHPAs in a population racially/ethnically similar to the fathers. Results In Phase 1, LFHPAs were identified in 16 of 244 fathers (6.55%). In Phase 2, LFPAs were found in only 28 of 1067 fathers (2.62%). LFHPAs were identified in 27 of 1338 maternal samples (2.01%). HPA-9bw was by far the most common LFHPA identified in the populations studied and was the only LFHPA that was significantly more common in fathers than in mothers of affected infants (P=0.02). Conclusions Maternal immunization against recognized LFHPAs accounts for only a small fraction of the cases of apparent NAIT not resolved by standard serologic testing. Typing of the fathers of such cases for LFHPAs is likely to be rewarding only when a maternal antibody specific for a paternal platelet glycoprotein is demonstrated and/or there is compelling clinical evidence for NAIT.

show abstract

Section: Discussionmentioning

confidence: 99%

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In a recent large cohort study on antibodies in FNAIT, low‐frequency HPAs were estimated as not significant 24 . However, intensive analysis of maternal sera with paternal PLTs in experienced laboratories revealed a constantly growing number of low‐frequency PLT antigens as well as first examples of repeated immunizations against already known HPAs 10,22,25,26 .…”

Section: Discussionmentioning

confidence: 99%

A new platelet alloantigen, Swi^a, located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia

Kroll

Feldmann²,

Zwingel³

et al. 2011

Transfusion

Self Cite

View full text Add to dashboard Cite

show abstract

“…137 In addition, HPA-6bw is a more common polymorphism to the Finnish population that causes FNAIT. 138 HPA-5 is located on integrin α2 subunit of the collagen receptor and is the second most common antigen causing FNAIT accounting for 10%–15% of all cases. 139 The reported incidence of FNAIT due to HPA-2 on GPIbα is rare.…”

Section: Gene Polymorphisms and Platelet Alloantigens In Fnaitmentioning

confidence: 99%

Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia

et al. 2015

View full text Add to dashboard Cite

Platelets play critical roles in hemostasis and thrombosis. Emerging evidence indicates that they are versatile cells and also involved in many other physiological processes and disease states. Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life threatening bleeding disorder caused by fetal platelet destruction by maternal alloantibodies developed during pregnancy. Gene polymorphisms cause platelet surface protein incompatibilities between mother and fetus, and ultimately lead to maternal alloimmunization. FNAIT is the most common cause of intracranial hemorrhage in full-term infants and can also lead to intrauterine growth retardation and miscarriage. Proper diagnosis, prevention and treatment of FNAIT is challenging due to insufficient knowledge of the disease and a lack of routine screening as well as its frequent occurrence in first pregnancies. Given the ethical difficulties in performing basic research on human fetuses and neonates, animal models are essential to improve our understanding of the pathogenesis and treatment of FNAIT. The aim of this review is to provide an overview on platelets, hemostasis and thrombocytopenia with a focus on the advancements made in FNAIT by utilizing animal models.

show abstract

Alloantibodies against low‐frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases

Abstract: It was concluded that the minor alleles of HPA-4 and -6bw to -17bw are exceptionally rare in the Caucasian population and therefore do not explain the large number of FMAIT referrals which test negative for the common HPA antibodies.

Cited by 35 publications

References 19 publications

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

A new platelet alloantigen, Swi^a, located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia

Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia

Contact Info

Product

Resources

About

Alloantibodies against low‐frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases

Abstract: It was concluded that the minor alleles of HPA-4 and -6bw to -17bw are exceptionally rare in the Caucasian population and therefore do not explain the large number of FMAIT referrals which test negative for the common HPA antibodies.

Cited by 35 publications

References 19 publications

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

Low‐frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia

A new platelet alloantigen, Swia, located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia

Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia

Contact Info

Product

Resources

About

A new platelet alloantigen, Swi^a, located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia