Almost two years with COVID-19: some aspects of antibiotic use

Ортенберг, Э А

doi:10.36488/cmac.2021.3.248-253

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…По сообщению Э.А. Ортенберга, реальная необходимость назначения АМП отмечается лишь для 6-8 % пациентов, у которых развиваются бактериальные осложнения [2]. Неправильное использование антимикробных препаратов (АМП) в период пандемии НКИ привело к дополнительному косвенному прессингу, способствуя отбору устойчивых к антибиотикам форм бактерий за счет гибели чувствительных к АМП вариантов, что создает предпосылки для формирования лекарственной устойчивости основных видов микроорганизмов, циркулирующих в стационарах.…”

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Comparative Analysis of Bacterial Microflora Isolated from Adult Pneumonia Inpatients and Hospital Objects in the Amur Region

Bondarenko¹,

Курганова²,

Троценко³

et al. 2022

PH&LE

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Background: The COVID-19 pandemic has exacerbated the problem of healthcare-associated infections and worsened the situation with the hospital spread of antibiotic resistant strains potentially inducing nosocomial infections. Objective: To compare bacterial microflora isolated from adult pneumonia inpatients and hospital objects and to assess the risk of hospital-acquired infections in the Amur Region. Materials and methods: The study was conducted in a multidisciplinary and a “COVID” hospital hereinafter referred to as Hospitals 1 and 2, respectively. Parallel bacteria culture testing of 519 sputum samples from 284 inpatients and 486 wipe samples collected weekly during 12 weeks in both hospitals was carried out using a classical method. AutoSCAN-4 and Vitek® 2 Compact 30 analyzers were applied to identify pathogens and determine their antimicrobial susceptibility. Results: Along with the detection of pathogenic bacteria in 33.8 % of hospitalized patients with pneumonia, we found pathogens in 23.3 % and 12.4 % of wipe samples from Hospitals 1 and 2, respectively, and established that the proportion of Gram-negative bacteria in them was 44.9 % and 15.4 % while the share of multidrug-resistant strains was 32.7 % and 3.8 %. The significant differences observed can be attributed to a more stringent disinfection regime in Hospital 2. The structure of multidrug-resistant Gram-negative bacteria was noted for a high proportion of carbapenem-resistant organisms isolated from both sputum (20.0 %) and wipe (38.9 %) samples. Conclusion: Our monitoring results helped define the composition and ratio of bacterial pathogens isolated from pneumonia cases and hospital objects. A wide range of pathogens, including those resistant to antibiotics, often detected in wipe samples and their accumulation over time indicate the potential hazard of the hospital environment posing an increased risk of hospital-acquired infections.

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Comparative Analysis of Bacterial Microflora Isolated from Adult Pneumonia Inpatients and Hospital Objects in the Amur Region

Bondarenko¹,

Курганова²,

Троценко³

et al. 2022

PH&LE

View full text Add to dashboard Cite

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Microbial associations for pneumonia causative agents and level of their resistance to antimicrobial drugs during a new coronavirus infection pandemic

Kolotova,

Kataeva,

Vakarina

et al. 2024

Russian Journal of Infection and Immunity

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Introduction. Bacterial coinfection and secondary bacterial infection are considered critical risk factors for the severity and mortality of SARS-CoV-2-caused pneumonia. The aim of the study was to analyze a pattern of microbial associations between K. pneumoniae and A. baumannii isolated from the lower respiratory tract discharge and sectional material (lung tissue) of patients diagnosed with pneumonia, and to compare resistance level in monoculture and associations during new coronavirus infection pandemic. Materials and methods. A bacteriological study of 2689 sputum and bronchial washing samples from patients at infectious diseases hospitals, and 1411 lung pathological material samples was carried out. Bacterial isolates were identified by mass spectrometry. Antibiotic sensitivity for isolates was determined by the disk diffusion method. Genetic determinants of resistance to beta-lactam antibiotics were detected by PCR. Statistical data processing was performed using SPSS version 22 software. Results. K. pneumoniae and A. baumannii isolates were predominantly found in two- and three-pathogen associations. It was established that the resistance level of K. pneumoniae isolates in association with A. baumannii is significantly higher compared to that in monoculture for all antimicrobial drugs studied. At the same time, K. pneumoniae in combination with Candida spp. vs monoculture showed significantly lower level of resistance to ciprofloxacin, amikacin, cefotaxime, ceftazidime and amoxicillin/clavulanic acid. K. pneumoniae isolates carried resistance determinants to extended-spectrum beta-lactamases: OXA-48 — (22.5%), OXA-51 — (5.6%), OXA-23 — (4.2%), KPC — 70.9%, NDM — 7%. Of these, 14.1% of strains had the ability to co-produce serine carbapenemases OXA-48 and KPC. Sputum and lung tissue A. baumannii isolates exhibited extremely high multiple resistance regardless of their associations with other microorganisms. Microbiome species similarity in the lower respiratory tract and lung tissue discharge was revealed. The proportion of lung tissue vs sputum resistant strains of K. pneumoniae and A. baumannii was significantly higher. Conclusion. The detection of of multiple drug resistant K. pneumoniae and A. baumannii isolates as well as their associations may indicate aggravated pneumonia severity.

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Almost two years with COVID-19: some aspects of antibiotic use

Cited by 2 publications

References 45 publications

Comparative Analysis of Bacterial Microflora Isolated from Adult Pneumonia Inpatients and Hospital Objects in the Amur Region

Comparative Analysis of Bacterial Microflora Isolated from Adult Pneumonia Inpatients and Hospital Objects in the Amur Region

Microbial associations for pneumonia causative agents and level of their resistance to antimicrobial drugs during a new coronavirus infection pandemic

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