Aloe vera extract reduces 8-oxo-2'-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats

Christijanti, Wulan; Marianti, Aditya; Isnaeni, Wiwi

doi:10.18051/univmed.2017.v36.34-41

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…DNA fragmentation and the intracellular concentration of 8-oxo-2′-deoxyguanosine were also increased significantly in diabetic patients (Shin et al 2001 ; Rama Raju et al 2012 ). Aloe vera extract significantly reduces the level of 8-oxo-dG and DNA fragmentation in STZ-induced diabetes (Christijanti et al 2017 ; Christijanti et al 2019b ). Haritha et al ( 2014 ) reported that oxidative stress was lowered by the oral administration of A. vera gel extract at a dose of 300 mg/kg body weight.…”

Section: Aloe Vera and Stz-induced Diabetesmentioning

confidence: 99%

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Haghani

Arabnezhad

Mohammadi

et al. 2022

Rev. Bras. Farmacogn.

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Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys, and cardiovascular and neurological systems. Herbal agents and their derived supplements have been used for treatment of diabetes mellitus as a part of integrated complementary medicine for centuries. Numerous studies have considered Aloe vera (L.) Burm.f, Xanthorrhoeaceae, as an alternative medicine due to its abundant bioactive chemicals, such as alkaloids, anthraquinones, and enthrones, with therapeutical properties including antioxidant, anti-inflammatory, neuro-protective, and anti-diabetic effects. Aloe vera has received considerable attention in traditional medicine for the treatment of several diseases including diabetes mellitus. Numerous studies have investigated the effects of herbal agents on diabetes mellitus using a streptozotocin-induced diabetic model. Thereby, this article reviews the effects of Aloe vera prescription on streptozotocin-induced diabetes mellitus to provide a clear insight into the role of this medicinal plant in several biological functions, such as antioxidant, wound healing, anti-inflammatory, anti-hyperglycemic, and anti-hyperlipidemic in diabetic models.

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Section: Aloe Vera and Stz-induced Diabetesmentioning

confidence: 99%

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Haghani

Arabnezhad

Mohammadi

et al. 2022

Rev. Bras. Farmacogn.

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“…These results are in agreement with (Sadri et al ., 2017)who observed that, Plasma levels of MDA were significantly increased While antioxidant enzymes such as SOD and PON1 activities were significantly decreased in diabetic rats received an intraperitoneal injection of STZ(55 mg/kg; i.p)in comparison with normal control rats. In addition, Christijanti et al . (2017) reported that the 8-oxo-dG levels were significantly increased in diabetic rats received an intraperitoneal injection of STZ (65 mg/kg; i.p) .…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats

Elbably

Elhamid

El-Nahas

2019

Benha Veterinary Medical Journal

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This study evaluated the protective effect of Sukkari date extract on Streptozotocin(STZ)induced diabetes in rats. Forty male albino rats were divided into 2 main groups: Group I (Control group, n=10): received no drugs and served as control. Group II (Diabetic group, n=30):received a single dose of STZ (50mg/kg b.wti.p.) for induction of diabetes, and 48hoursafterdiabetes induction,the rats were divided into 3 equal subgroups. Subgroup (a): Diabetic non-treated rats.Subgroup (b): Diabetic aqueous sukkari date extract-treated rats.Subgroup (c): DiabeticAmaryl-treated rats. Treatment with sukkari date extract(10 ml/rat/day) and Amaryl(1ml/rat/day) were given orally and daily for 60 days. Blood samples and liver tissues were collected from all animals once after 60 days of treatment for determination of serum glucose, lipids profile, insulin,L-malondialdehyde (L-MDA), superoxide dismutase (SOD) and 8-hydroxy-2-deoxyguanosine (8-OHdG) inaddition to paraoxonase 1 (PON1) gene expression level in liver tissue. The obtained results showed a significant increase in serum glucose, total cholesterol, triacylglycerols, low density lipoprotein-cholesterol (LDL-c), L-MDA and 8-OHdG levels with marked decrease in serum insulin, high density lipoprotein-cholesterol (HDL-c) and SOD activity in addition to significant down-regulation of PON1 gene expression level in liver in STZ-induced diabetic rats.On the other hand, treatments of diabetic rats with aqueous sukkari date extract or amaryl exhibited a significant ameliorative effect on all previous biomarkers and approximately reach to normal levels. This study suggest the ameliorativerole of aqueous sukkari date extract in diabetes and its protective effect may be mediated through reduction in oxidative stress, the promising hypoglycemic and hypolipidemic activity.

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“…18 Other researchers state that peel extracts can significantly reduce serum 8-oxo-dG levels compared to the gel. 19…”

Section: Introductionmentioning

confidence: 99%

Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats

Christijanti¹,

Juniarto²,

Suromo³

2019

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Background: Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia. Aim: The present study aimed to evaluate the effect of Aloe vera peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. Materials and Methods: Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level > 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by Aloe vera peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. Results: The levels of SOD, CAT, and GSH in the group receiving Aloe vera peel extract were statistically significant (p <0.05) higher than the control. There were also significant differences between the dose variations group. Conclusion: Aloe vera peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.

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Aloe vera extract reduces 8-oxo-2'-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats

Cited by 6 publications

References 23 publications

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

Ameliorative effect of Sukkari date extract on STZ induced experimentally diabetes in male rats

Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats

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