Alpha-Fetoprotein Following Neonatal Resection of Sacrococcygeal Teratoma

Barreto, Maria Weber Guimarães; Silva, Luciana Vivas; Barini, Ricardo; Oliveira-Filho, Antônio Gonçalves de; Sbragia, Lourenço

doi:10.1080/08880010600629056

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…The cell cycle of the two-cell embryos in the mouse has duration of 20–26 h with G 1 and S phases that last ∼1–2 and 6–7 h; these phases are followed by an extended G 2 phase (12–15 h) and M (mitosis) phase of 1–2 h ( 49 ). Many plant extracts have been used as a source of medicinal agents to cure urinary tract infections, cervicitis vaginitis, gastrointestinal disorders, respiratory diseases, cutaneous problems, helmintic infections, parasitic protozoan diseases, and antitumor and antimicrobial ( 17 , 50 – 53 ). The results of this investigation may improve our understanding in usage of this plant as an alternative anticancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Indigofera suffruticosa: An Alternative Anticancer Therapy

Vieira

Souza

Nascimento

et al. 2006

Evidence-Based Complementary and Alternative Medicine

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Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves of I. suffruticosa obtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg−1 (intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves of I. suffruticosa may be used as an alternative anticancer agent.

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Section: Discussionmentioning

confidence: 99%

Indigofera suffruticosa: An Alternative Anticancer Therapy

Vieira

Souza

Nascimento

et al. 2006

Evidence-Based Complementary and Alternative Medicine

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“…In addition to its prognostic value, the AFP assay is an excellent means for postoperative follow-up; as it falls after tumor resection, and rises in case of recurrence or metastases. According to some studies, normalization of AFP after tumor resection occurs between 6 and 12 months, however, its recommended dosage every 3 to 6 months for 3 years after surgery [28,31]. the clinic and complementary examinations allowed us to classify our patient into the SCT type II of Altman's classification.…”

Section: Discussionmentioning

confidence: 94%

“…The normal AFP level at birth can be 100,000 ng / ml. The interpretation of the AFP rate is only possible thanks to the Tsuchida chart [28,29]. This marker is considered as an important key for the clinical differentiation between benign and malignant teratomas, as well as for evaluating the efficacy of treatment [30].…”

Section: Discussionmentioning

confidence: 99%

Sacro-coccygeal Teratoma in a Child of 6 Months: A Case Report

Frederic¹,

Paul²,

Essola³

et al. 2019

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Sacro-coccygeal teratoma (SCT) is a type of tumor which mostly occurs in newborn babies. The vast majority of this type of tumor is benign. That pathology can be diagnosed antenatally or at birth. Teratomas, especially those diagnosed in the neonatal period, occur most frequently in the sacrococcygeal region. Clinically in many cases, we can observe a large swelling (mass) in the sacrococcygeal region. In some cases, there are signs of compression following by the displacement of the rectum and pelvic organs. Alphafetoprotein is the main biological test used. In association morphologically by echography, CT-scan, MRI and others, the tumor is classified. The classification used is the topographical one of TSCs, which was proposed by Altman to the American Academy of Pediatric Surgery. The mainstay of therapy is the complete surgical removal. We present a case of a newborn (6 months), female, with teratoma sacro-coccygeal. At birth the baby was noticed to have large swelling (mass), without any sign of compression of others organs. Clinical and paraclinical signs permitted us to conclude of a SCT type II of Altman's classification. A surgery was performed with a sacral approach. Histologically, tumors were classified into good (mature) category.

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“…Interestingly, AFP values were far higher in patients with metastatic disease than in the one with IVC. We might speculate that such a difference may be due to AFP production from metastatic cells retaining their fetal potential [11].…”

Section: Casementioning

confidence: 99%

Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

et al. 2007

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Alpha-fetoprotein (AFP) is a common tumoral marker in pediatric neoplasms; increased serum levels are usually encountered in tumors arising from tissues producing AFP during fetal life. However, elevation of such protein is rarely found in patients with Wilms tumor (WT). Three patients with WT and elevated serum AFP were studied over the course of the disease. One patient had left WT with invasion of aorto-caval lymph nodes and lung metastases. The second patient was referred to our center for abdominal recurrence of bilateral WT whereas the third showed right WT with inferior vena cava thrombosis. AFP levels demonstrated a trend parallel to decrease/increase of tumor size, with further elevation in patients with metastases. Elevated AFP serum levels in patients with WT could be related to peculiar histological features and serial dosage might be a useful diagnostic and prognostic test.

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Alpha-Fetoprotein Following Neonatal Resection of Sacrococcygeal Teratoma

Cited by 22 publications

References 11 publications

Indigofera suffruticosa: An Alternative Anticancer Therapy

Indigofera suffruticosa: An Alternative Anticancer Therapy

Sacro-coccygeal Teratoma in a Child of 6 Months: A Case Report

Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

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