Alpha Glukosidase Inhibitory Test and Total Phenolic Content of Ethanol Extract of Parkia Speciosa Plant

Fitria, Fitrya; Annisa, Andi Nurul; Nikita, S; Ranna, C

doi:10.26554/sti.2019.4.1.1-4

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Six studies comprising three in vitro and three in vivo studies have demonstrated hypoglycemic activity of the plant, but no clinical study has been conducted. Most of the studies have studied the activity in the seeds and pods [ 120 , 156 , 157 , 158 ].…”

Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

“…The seeds also show inhibitory activity but at lower percentage (45.72%) [ 156 ]. In another study, the ethanol extract of the rind had the highest α-glucosidase inhibitory activity followed by the leaf and seed with IC 50 of 4596 ppm, 54,341 ppm, and 67,425 ppm, respectively as compared with acarbose having 162,508 ppm [ 158 ].…”

Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

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Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Saleh

Jalil

Zainalabidin

et al. 2021

IJMS

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The genus Parkia (Fabaceae, Subfamily, Mimosoideae) comprises about 34 species of mostly evergreen trees widely distributed across neotropics, Asia, and Africa. This review aims to provide an overview of the current status of the species from the genus Parkia in terms of its relationship between its phytochemistry and medical uses. Comprehensive information on Parkia species was retrieved from electronic databases, which were Web of Science, ScienceDirect, PubMed, and Google Scholar. This review identified nine species from genus Parkia with properties of medicinal use. They are used traditionally to treat several ailments, such as diabetes, diarrhea, wounds, hypertension, cough, chronic piles, conjunctivitis, and measles. The most common species studied are P. biglobosa, P. speciosa, P. javanica, P. bicolor, P. biglandulosa, P. filicoidea, and P. clappertoniana. A considerable number of secondary metabolites, such as terpenoids, phenolic acids, flavonoids (aglycone and glycosides), and numerous volatile compounds have been identified in this genus, which are responsible for their diverse pharmacological activities. Their extracts, pure compounds and seed lectins have been reported for their anticancer, antimicrobial, antihypertensive, antiulcer, antidiabetic, anti-inflammatory, antioxidant, antimalarial, hepatoprotective, and antidiarrheal activities. The information gathered in this review might be of help for future studies in terms of the current knowledge on the link between the phytochemical components and medicinal uses. This could facilitate more discoveries on its potentials particularly in the pharmacological characteristics and potential to be developed into modern medicines.

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Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

Section: Pharmacological Activities Of Parkia Smentioning

confidence: 99%

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Saleh

Jalil

Zainalabidin

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…One kg of dry Benalu leaf powder was extracted by maceration method using 3 L of 70% ethanol three times. After filtering, the total filtrate was evaporated with a rotavapor (Yamato® RE301) to obtain an ethanol extract of Benalu leaves (EDP) (Fitrya et al, 2019) .…”

Section: Extract Preparationmentioning

confidence: 99%

Gastroprotective Effects of Dendropthoe pentandra Leaf Ethanol Extract on Peptic Ulcer Animal Models

Fitrya

Amriani

Novita

et al. 2023

Sci. Technol. Indones

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Dendrophthoe pentandra (Loranthaceae) is a semi-parasitic plant with several diverse metabolites and biological activities and is widely used in traditional medicine. This study aims to evaluate the gastroprotective effectiveness of the ethanol extract of D. pentandra leaves in animals induced by an acute peptic ulcer with absolute ethanol. The gastroprotective effect of the extract (100, 250 and 500 mg/kg doses) was evaluated through ulcer index parameters, physicochemical properties of gastric fluid, and histopathological analysis. The study results of the study showed that the ethanol extract of D. pentandra leaves at a dose of 500 mg/kg could provide a protective effect equivalent to omeprazole. Histopathological analysis proved the improvement of the mucous membrane structure in the animals pre-treated with the extract. Based on these findings, it can be concluded that the ethanol extract of D. pentandra leaves is effective as an anti-ulcer drug, so it is feasible to be developed as a gastroprotective from herbal.

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“…Traditionally, these plant seeds have been used by locals to treat various diseases and symptoms like diabetes, kidney disorder, headache, hypertension, skin problems, and diarrhea [ 6 , 7 , 8 ]. Scientifically, P. speciosa has been reported to possess hypoglycemic [ 9 , 10 , 11 ], antioxidant [ 8 , 12 , 13 , 14 , 15 ], anti-inflammatory [ 16 , 17 ], and antihypertensive [ 18 , 19 ] properties. The polyphenols found in this plant include gallic acid, ellagic acid, catechin, quercetin, vanillic acid, and epicatechin [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

et al. 2022

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Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and is considered a major health problem in the world. It is associated with endothelial dysfunction which causes progressive vascular damage. DM is a known risk factor for atherosclerosis and cardiovascular complications such as peripheral artery disease, coronary artery disease, and stroke. Medicinal plants may act as an alternative resource or adjunctive treatment option in the treatment of diabetes and its cardiovascular complications. Parkia speciosa (Fabaceae) is a plant found abundantly in the Southeast Asian region. Its seeds, with or without pods, and roots have long been used as a traditional medicine in this region to treat hypertension and diabetes. Studies have shown its numerous beneficial pharmacological properties. Extracts of P. speciosa, particularly from its seeds and empty pods, show the presence of polyphenols. They also exhibit potent antioxidant, hypoglycemic, anti-inflammatory, and antihypertensive properties. Its hypoglycemic properties are reported to be associated with the presence of β-sitosterol, stigmasterol, and stigmat-4-en-3-one. The current review aimed to provide an overview of the current status of P. speciosa, its pharmacological potential, and its phytochemical content in attenuating diabetic vasculopathy. Glycemic status, oxidative stress, inflammation, and hyperlipidemia are known to play pivotal roles in the initiation and severity of diabetic cardiovascular diseases; thus, targeting these factors might be beneficial for preventing and/or treating diabetic vasculopathy.

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Alpha Glukosidase Inhibitory Test and Total Phenolic Content of Ethanol Extract of Parkia Speciosa Plant

Cited by 4 publications

References 10 publications

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Genus Parkia: Phytochemical, Medicinal Uses, and Pharmacological Properties

Gastroprotective Effects of Dendropthoe pentandra Leaf Ethanol Extract on Peptic Ulcer Animal Models

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

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