Alpha-pinene modulates inflammatory response and protects against brain ischemia via inducible nitric oxide synthase-nuclear factor–kappa B-cyclooxygenase-2 pathway

Shabani, Mohammad; Erfani, Sohaila; Abdolmaleki, Arash; afzali, Fatemeh Ephtekhar; Khoshnazar, Seyedeh Mahdieh

doi:10.1007/s11033-023-08480-8

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…Through the nuclear factor-kappa B-cyclooxygenase-2 pathway, α-Pinene suppresses inflammatory response and provides protection against brain ischemia. (Shabani et al, 2023;Salehi et al, 2019). The compound has a direct interaction with the protein target, neuronal acetylcholine receptor protein α-7 subunit (NACHRA7), which is consistent with the findings in Table 1, which reveal that α-pinene is cytotoxic to brain glaucoma cells.…”

Section: Discussionsupporting

confidence: 84%

In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines

Caasi,

Baldoza,

Bauzon

et al. 2023

Asian Pac J Cancer Prev

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Objective: Alpinia elegans (Zingiberaceae) is a Philippine endemic plant reported to have various folkloric uses. The seed oil of A. elegans has been shown to contain a majority of the following bioactive compounds: D-limonene, α-pinene, and caryophyllene oxide. The study sought to determine if the bioactive compounds found in A. elegans seed oil would be a good natural, inexpensive, and less-detrimental alternative for cancer treatment. Methods: The study utilized in silico (Way2Drug predictive services, SwissADME, AutoDock 4) experiment to examine the aforementioned compounds as viable therapeutic candidates against human cancer cell lines. Result: Results determined that the compounds D-limonene, α-pinene, and caryophyllene oxide were most potent against thyroid gland carcinoma (8505C) cells, brain glaucoma (Hs 683) cells, and promyeloblast leukemia (HL-60) cells, respectively. Additionally, D-limonene was the only compound to show arrhythmia as an adverse effect. Predictions showed that the compounds could inhibit cellular growth factors and serine/threonine-protein kinase activity. The compounds generated a bioavailability score of 0.55 and exhibited blood-brain barrier (BBB) penetration. D-limonene, α-pinene, and caryophyllene oxide had binding energy of -4.59, -5.43, and -6.92, respectively. Conclusion: The binding energy indicated that the ligands could securely dock to the receptors, thus suggesting that interaction between the ligands and receptors was stable. Results have shown that the compounds are promising candidates against human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.

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Section: Discussionsupporting

confidence: 84%

In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines

Caasi,

Baldoza,

Bauzon

et al. 2023

Asian Pac J Cancer Prev

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“…Some studies have investigated the effect of alpha-pinene on normoxic rats, which are rats that are exposed to normal levels of oxygen. For example; alpha-pinene modulates the inflammatory response and protects against brain ischemia–reperfusion injury in normoxic rats by inhibiting the inducible nitric oxide synthase (iNOS)-nuclear factor kappa B (NF-κB)-cyclooxygenase-2 (COX-2) pathway and reducing caspase-3 activation 32 . Alpha-pinene enhances the gastric mucosal defense and reduces the ethanol-induced gastric damage in normoxic rats by upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression 33 and alpha-pinene does not cause significant toxicity or carcinogenicity in normoxic rats when administered by inhalation for up to 2 years 34 .…”

Section: Discussionmentioning

confidence: 99%

Alpha-pinene ameliorate behavioral deficit induced by early postnatal hypoxia in the rat: study the inflammatory mechanism

Bakhtazad,

Ghotbeddin,

Tabandeh

et al. 2024

Sci Rep

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Neonatal hypoxia has a negative impact on the developing brain during the sensitive period. Inflammation plays a key role in the physiological response to hypoxic stress. Considering the anti-inflammatory properties of alpha-pinene, which has received a lot of attention in recent years, in this research we focused on the impact of alpha-pinene on the behavioral responses and proinflammatory factors in rats subjected to the neonatal hypoxia. This study involved Wistar rats (7-day-old) that were divided into six experimental groups, including a control group, groups receiving different doses of alpha-pinene (5 and 10 mg/kg), a hypoxia group receiving 7% O2 and 93% N2, 90 min duration for 7 days, and groups receiving alpha-pinene 30 min before hypoxia. All injections were done intraperitoneally. The rats were evaluated for proinflammatory factors 24 h after exposure to hypoxia (PND14) and at the end of the behavioral test (PND54). The results showed that hypoxia led to decreased motor activity, coordination, and memory, as well as increased inflammation. However, the rats that received alpha-pinene showed improved behavioral responses and reduced inflammation compared to the hypoxia group (all cases p < 0.05). This suggests that alpha-pinene may have a protective effect via anti-inflammatory properties against the negative impacts of hypoxia on the developing brain.

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Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

Pham,

Hoang,

et al. 2024

Chemistry & Biodiversity

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Three species of the Rutaceae family, including Acronychia pedunculata, Euodia lepta, and Severinia monophylla have been used in traditional medicine. However, the comparison of the chemical composition, anti‐cancer, and anti‐inflammatory effects of the leaf essential oils of these species have not been investigated yet. A total of 38 compounds were identified via gas chromatography‐mass spectrometry, comprising 96.5–99.8 % of the total composition. Both A. pedunculata and E. lepta essential oils exhibited strong inhibitory effects against cancer cells (IC50: 59.04–97.52 μg/mL) while that of S. monophylla showed a lower anti‐cancer effect (IC50>100 μg/mL). Among three essential oils, only the E. lepta leaf oil demonstrated a high anti‐inflammatory effect on LPS‐stimulated macrophages (IC50=6.47±0.65 μg/mL), while the others showed a moderate anti‐inflammatory effect (IC50>50 μg/mL). Molecular docking studies also suggested the binding potential of the key compounds from three essential oils against inducible nitric oxide synthase and cyclooxygenase‐2, two proteins associated with inflammatory response, with the negative energies ranging from −41.0 to −71.9 kcal/mol. The present findings suggest the leaf essential oils from these species as potential medicines for treatment of cancer or inflammation associated diseases, especially the ones from A. pedunculata and E. lepta oils.

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Alpha-pinene modulates inflammatory response and protects against brain ischemia via inducible nitric oxide synthase-nuclear factor–kappa B-cyclooxygenase-2 pathway

Cited by 9 publications

References 35 publications

In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines

In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines

Alpha-pinene ameliorate behavioral deficit induced by early postnatal hypoxia in the rat: study the inflammatory mechanism

Chemical Compositions, Molecular Docking, Anti‐Inflammatory, and Anti‐Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam

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