Alterações fisiológicas e metabólicas em indivíduo com distrofia muscular de Duchenne durante tratamento fisioterapêutico: um estudo de caso

Gevaerd, Monique da Silva; Domenech, Susana Cristina; Júnior, Noé Gomes Borges; Higa, Daniela Fernanda; Lima‐Silva, Adriano Eduardo

doi:10.1590/s0103-51502010000100009

Cited by 9 publications

(8 citation statements)

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“…The same occurred with the diaphragm muscle, where the mdx animals showed signi cantly higher lipid peroxidation levels when compared to the non-exercised mdx animals, demonstrating that the exercise protocol for four weeks was able to prevent the increase in lipid peroxidation. However, swimming was not able to reverse the increase in protein carbonation in diaphragm [4]. Considering what was exposed, it can be suggested that moderate intensity aerobic exercise -swimming -can reduce oxidative stress by increasing antioxidant defenses such as the glutathione, considering the increase in the formation of free thiols shown in the results of this study.…”

Section: Discussionmentioning

confidence: 52%

“…Evidence suggests that oxidative stress is associated with the aggravation of both respiratory and muscular pathology in these patients [19]. In addition, there are studies that show that exercise can protect against oxidative stress in skeletal muscle in mdx mice [4,13]. The protocol used in this study protected against the increase in lipid peroxidation in gastrocnemius in mdx animals.…”

Section: Discussionmentioning

confidence: 81%

“…Patients diagnosed with DMD require a multidisciplinary treatment approach, which must be careful and always focus on the well-being of the patient. Therefore, the role of the physical therapy is important for a successful treatment, once it has achieved good outcomes in the short term, such as maintaining the autonomy of these individuals [4,5]. Physical exercises are also used to treat DMD [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

et al. 2021

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Duchenne muscular dystrophy (DMD) is a genetic disease, which is associated to progressive skeletal muscle degeneration. In humans, DMD has early onset, causes developmental delays, and is a devastating disease that drastically diminishes the quality of life of the young individuals affected. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of Duchenne muscular dystrophy. Male mdx and wild type mice within 28 days were used in this study. The animals were trained in a stepped swimming protocol for four consecutive weeks. It was veri ed that swimming was able to reduce signi cantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius and hippocampus and striatum in exercised animals. Swimming has also prevented lipid peroxidation in diaphragm. Besides, this swimming protocol was able to increase free thiols in gastrocnemius, diaphragm and in all central nervous system structures. These results showed that a protocol of swimming as an aerobic exercise of low intensity, for four weeks, prevented aversive memory and habituation in mdx mice.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

et al. 2021

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“…As crianças realizaram o teste de caminhada na piscina em uma área denominada platô (superfície plana onde e realizado o treino de marcha) e percorreram uma distancia de 15 metros durante 06 minutos, foi oferecido o mesmo comando verbal do solo. Foi realizado primeiro o teste em solo e em seguida as crianças foram orientadas a manter o repouso de 30 minutos com objetivo de retornar os parâmetros basais e eliminar o fator fadiga 9,12,13 . Após este período foi realizado o teste no ambiente aquático.…”

Section: Procedimentounclassified

Energy expenditure analysis in Duchenne muscular dystrophy in land and aquatic environment

Silva

Hengles²,

Verdiani³

et al. 2015

RNC

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original RESUMO Introdução. A Distrofia Muscular de Duchenne (DMD) é uma doença progressiva, caracterizada pela degeneração progressiva das fibras musculares necessitando de maior demanda energética durante as atividades funcionais. Desta forma, é imprescindível a avaliação clínica do gasto energético em diferentes atividades e ambientes. Objetivos. Analisar o gasto energético de crianças com DMD durante a marcha nos ambientes aquático e terrestre. Método. Participaram deste estudo 8 meninos com DMD (10,4±0,5 anos), deambuladores, colaborativo para a realização dos testes, não estavam inseridos em programas de reabilitação e não apresentaram doenças associadas. Foi realizado o Teste de caminhada de 6 minutos e calculamos o índice de gasto energético (IGE) através da fórmula: FC final -FC inicial dividida pela velocidade (metros/segundo), sendo expresso em batimentos/ minuto nos meios aquático e terrestre. Resultados. Observamos que no ambiente aquático os pacientes com DMD percorreram um distância menor, comparado ao solo (p=0,012). Quanto ao Índice de Gasto Energético (IGE), os pacientes com DMD obtiveram uma média no solo de 0,43±0,15 e na água de 3,69±0,44 (p=0,012). Conclusões. Os pacientes percorreram uma distância menor e com um gasto energéti-co maior no ambiente aquático, quando comparado com o terrestre.Unitermos. Distrofia Muscular de Duchenne, Marcha, Metabolismo Energético, Ambiente Aquático Citação. Silva KM, Hengles RC, Verdiani MB, Cecconi ME, Rocco FM, Braga DM. Análise do gasto energético na Distrofia muscular de Duchenne nos ambientes aquático e terrestre. ABSTRACTIntroduction. Duchenne muscular dystrophy (DMD) is a progressive genetic disease, characterized by progressive and irreversible degeneration of muscle fibers, requiring energy demand during functional activities. Given this characteristic, energy expenditure becomes a key factor in a rehabilitation program. So, it is essential energy expenditure clinical assessment in different environments. Objective. Analyze the energy expenditure of children with DMD during gait in aquatic and land environments. Method. The study included 8 boys with DMD (10.4±0.5 years), ambulating and collaborative for testing. They were not included in rehabilitation programs and had no associated diseases. It was applied 6-minute walk test (6MWT) in land and aquatic environment, and calculate energy expenditure index by the formula: End FC -divided by the initial speed FC (meters/ second) and is expressed in beats/minute in the aquatic and terrestrial. Results. It was observed that DMD patients walked (p=0.012) a shorter distance in water in relation to the ground. DMD patients had (p=0.012) higher average of energy expenditure in aquatic environment (3.69±0.44) when compared to land (0.43±0.15). Conclusion. The patients walked a shorter distance and with higher energy expenditure in aquatic environment.Keywords. Muscular Dystrophy Duchenne, Gait, Energy Metabolism, Aquatic Environment Citation. Silva KM, Hengles RC, Verdiani MB, Cecconi ME, Rocco FM, Braga DM....

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“…Treatment of patients diagnosed with Duchenne muscular dystrophy (DMD) needs to be multidisciplinary, careful, and always focused on the well-being of the patient. Given this, the role of physical therapy becomes crucial to the success of treatment, as it has achieved good results in the short term, such as maintenance of the autonomy of these individuals [4,5]. Another method that has been used to treat DMD is physical exercise [6,7].…”

Section: Introductionmentioning

confidence: 99%

Swimming Prevents Memory Impairment by Increasing the Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

Ribeiro

Alberti

Freiberger

et al. 2019

Preprint

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Duchenne muscular dystrophy (DMD) is a genetic disease which is associated to a 17 progressive skeletical muscle degeneration. Swimming is usually indicated for avoiding 18 impact and facilitating adherence because of a better adaptation to a warm water 19 invironment and also for its benefits on cognition, and modulating memory and learning 20 processes and for increasing antioxidant defenses in oxidative stress. The objective of this 21 study was to evaluate the effects of a swimming protocol on memory and oxidative stress 22 in an animal model of Duchenne muscular dystrophy. Methods: male mdx and wild type 23 mice within 28 days were used in this study. The animals were trained in an stepped 24 swimming protocol for four consecutive weeks. Twenty four hours after the last exercise 25 day, aversive memory and habituation memory tests were performed and removed the 26 encephalic structures of striatus, pre frontal cortex, hippocampus, and cortex and 27 gastrocnemius and diafragma muscles to evaluate protein carbonilation and lipid 2 28 peroxidation and free thiols. Results: it was verified that swimming was able to reduce 29 significantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius 30 and hippocampus and striatus in exercised animals. Swimming has also prevented lipid 31 peroxidation in diafragma. Besides, this swimming protocol was able to increase free 32 thiols in gastrocnemius, diafragma and in analysed SNC structures. These results showed 33 that swimming prevented aversive and habituation memory in mdx mice. 34 Keywords: Duchenne muscular dystrophy, Swimming , oxidative stress 35 36 37 42 symptoms [1-3]. 43 Treatment of patients diagnosed with Duchenne muscular dystrophy (DMD) needs 44to be multidisciplinary, careful, and always focused on the well-being of the patient. 45Given this, the role of physical therapy becomes crucial to the success of treatment, as it 46 has achieved good results in the short term, such as maintenance of the autonomy of these 47 individuals [4,5]. Another method that has been used to treat DMD is physical exercise 48 [6,7]. Studies have been using physical exercise to decrease muscle deterioration, muscle 49 contractures, bone fractures, and increase the time of functional independence, in 50 individuals with DMD [8,9]. 51Swimming is one of the aerobic exercise modalities that has become very popular. 52Aerobic exercise in water is a viable alternative to exercise on land, because water, 3 53 through its physical properties such as thrust, hydrostatic pressure, and viscosity, among 54 others, brings increased well-being and quality of life [10]. Swimming, like walking and 55 running, has health benefits compared to a sedentary lifestyle [11]. Swimming is 56 generally indicated because with heated water it avoids impact and facilitates adherence 57 by better adaptation to the environment [11]. Swimming is further described in the 58 literature as having beneficial effects on patients: on cognition by modulating memory 59 and learning processes; and...

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Alterações fisiológicas e metabólicas em indivíduo com distrofia muscular de Duchenne durante tratamento fisioterapêutico: um estudo de caso

Cited by 9 publications

References 30 publications

Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

Energy expenditure analysis in Duchenne muscular dystrophy in land and aquatic environment

Swimming Prevents Memory Impairment by Increasing the Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

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