Alterações retinianas em jovens portadores de anemia falciforme (hemoglobinopatias) em hospital universitário no nordeste do Brasil

Santos, Allisson Mário dos; Faro, Gustavo Baptista de Almeida; Amaral, Marcus Vinicius Melo do; Mendonça, Cléverton de Oliveira; Leal, Bruno Campelo; Cipolotti, Rosana

doi:10.1590/s0004-27492012000500003

Cited by 5 publications

(9 citation statements)

References 10 publications

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“…Hence, the retinal periphery of patients with NPSCR is frequently characterized by precocious bilateral changes, peripheral closure/anastomoses, salmon-patch hemorrhages ( Figure 2 ), iridescent spots, and black sunbursts. 34 The central part of the retina usually reveals arteriovenous tortuosity, enlargement of the foveal avascular (non-perfused) zone (FAZ), CRAO (eye stroke), as well as peripapillary and perimacular arterial occlusions. 34 It is worthwhile to mention that CRAO is a rare but a potentially devastating cause of acute blindness in SCD.…”

Section: Pathogenesis Clinical Manifestations and Complications Of mentioning

confidence: 99%

Sickle cell retinopathy: improving care with a multidisciplinary approach

Menaa¹,

Khan²,

Uzair³

et al. 2017

JMDH

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Sickle cell retinopathy (SCR) is the most representative ophthalmologic complication of sickle cell disease (SCD), a hemoglobinopathy affecting both adults and children. SCR presents a wide spectrum of manifestations and may even lead to irreversible vision loss if not properly diagnosed and treated at the earliest. Over the past decade, multidisciplinary research developments have focused upon systemic, genetic, and ocular risk factors of SCR, enabling the clinician to better diagnose and manage these patients. In addition, newer imaging and testing modalities, such as spectral domain-optical coherence tomography angiography, have resulted in the detection of subclinical retinopathy related to SCD. Innovative therapy includes intravitreal injection of an anti-vascular endothelial growth factor (eg, Lucentis® [ranibizumab] or Eylea® [aflibercept]) which appears comparatively safe and efficient, and may be combined with laser photocoagulation (LPC) for proliferative SCR. The effect of LPC alone does not significantly lead to the regression of advanced SCR, although it helps in avoiding hemorrhage and sight loss. This comprehensive article is based on 10-years retrospective (2007–2017) studies. It aims to present advances and recommendations in SCR theranostics while pointing out the requirement of combinatorial approaches for better management of SCR patients. To reach this goal, we identified and analyzed randomized original and review articles, clinical trials, non-randomized intervention studies, and observational studies using specified keywords in various databases (eg, Medline, Embase, Cochrane, ClinicalTrials.gov).

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Section: Pathogenesis Clinical Manifestations and Complications Of mentioning

confidence: 99%

Sickle cell retinopathy: improving care with a multidisciplinary approach

Menaa¹,

Khan²,

Uzair³

et al. 2017

JMDH

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“…Ocular manifestations of sickle cell anemia include orbital, conjunctival, uveal, papillary, and especially retinal changes. 5,7,12 Retinal changes characterize sickle cell retinopathy, which may be non-proliferative or proliferative and is divided into five stages. 1,10,12,13 Among the forms of sickle cell anemia, SS patients present a more severe systemic clinical picture than those with type SC.…”

Section: Ocular Manifestationsmentioning

confidence: 99%

“…8 Diagnosis is made by retinography and fluorescein angiography in cases with fundoscopic alterations, as well as measurement of visual acuity and intraocular pressure. 5,7,8,13 treatMent Treatment is performed in different ways, including diathermy, cryotherapy and argon or xenon photocoagulation. The latter is widely used to treat the typical stage III lesion (sea fan) of proliferative retinopathy.…”

Section: Diagnosismentioning

confidence: 99%

“…3,4 The most common genotypes are homozygous (SS), heterozygous or sickle cell trait (SA), hemoglobin C trait (SC), hemoglobin D trait (SD), and thalassemia genotype (S-Thal). 1,[5][6][7][8] The World Health Organization (WHO) estimates that more than 5% of the world population has some type of hemoglobinopathy. The estimate of new cases in Brazil is 700 to 1,000 per year, with a prevalence of over 2 million carriers of the HbS gene.…”

Section: Introductionmentioning

confidence: 99%

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Sickle cell retinopathy: A literature review

Ribeiro

Jucá

Alves

et al. 2017

Rev. Assoc. Med. Bras.

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Hemoglobinopathies are a group of hereditary diseases that cause quantitative or qualitative changes in the shape, function or synthesis of hemoglobin. One of the most common is sickle cell anemia, which, due to sickling of erythrocytes, causes vaso-occlusive phenomena. Among the possible ocular manifestations, the most representative is retinopathy, which can lead to blindness if left untreated. Therefore, periodic ophthalmologic monitoring of these patients is important for early diagnosis and adequate therapeutic management, which can be done localy by treating the lesions in the eyes, or systemically.

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“…No gráfico 3 os autores David; Haroldo; Rodrigues 8 demonstraram em suas pesquisas um elevado número de adolescentes e adultos com 73% entre 16 a 45 anos com alterações oculares. Segundo Santos 9 as alterações retinianas em pacientes com 14,4 e 17,4 anos são de 62,30%. A colelitíase relatada na pesquisa de Gumeiro 6 , teve o índice de 45% na idade de 12,5 e 14 anos, porém Ohara 13 mostra que a capacidade funcional (dor osteomuscular) obteve um índice baixo de 5% na idade de 31,77 anos.…”

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Complicações Da Síndrome Falciforme

Cardoso

Barbosa

Pinheiro

et al. 2016

REC

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O presente artigo de revisão integrativa aborda e ressalta as principais complicações da anemia falciforme da criança ao adulto. A Síndrome Falciforme é uma importante hemoglobinopatia genética, um tipo de patologia peculiar pela produção de eritrócitos com deformidades falcêmicas, que ocasiona complicações como litíase biliar, crise álgica, crise do sequestro esplênico, acidente vascular cerebral isquêmico, alterações oculares, alterações retinianas. Objetivo: Destacar as principais complicações da anemia falciforme na criança, no adolescente e adultos auxiliando os profissionais de saúde na assistência ao paciente que apresenta essa patologia. Metodologia do estudo: Com a utilização do meio de informação acadêmico via internet de artigos encontrados na (BVS) Biblioteca Virtual em Saúde, foram utilizados os seguintes descritores: Anemia falciforme AND complicações, Doença Falciforme, Anemia Falciforme e Complicações. Pesquisados 7.544 artigos relacionados às complicações da anemia falciforme, na qual 11 são abordados no presente trabalho, com a utilização bibliográfica do Manual de Hematologia, autor Hamerschlak, Nelson e no Manejo das complicações agudas da doença falciforme conforme Brunetta et al. Resultados: As complicações que predominaram em crianças no presente estudo foi a hipertrofia adenotonsilar obstrutiva acometendo mais de 55% e em adolescentes e adultos foram as alterações oculares com mais de 73% dos clientes. Conclusão: Embora a patologia falciforme seja pouco discutida e de grande prevalência no Brasil devido a miscigenação racial, o presente estudo ressalta as principais complicações causadas pela mesma, tendo as crianças que apresentam uma prevalência de hipertrofia adenotonsilar obstrutiva acima de 55% mostrado no seguinte estudo, na qual o profissional de saúde deve estar atento a sintomatologia para que haja o tratamento adequado e as informações fornecidas aos pais ou responsáveis sejam adequadas para cada cliente. O adulto portador da anemia falciforme tem como principal complicação alterações oculares 73%, na qual o cuidador deve ter atenção a essas ocorrências.

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Alterações retinianas em jovens portadores de anemia falciforme (hemoglobinopatias) em hospital universitário no nordeste do Brasil

Cited by 5 publications

References 10 publications

Sickle cell retinopathy: improving care with a multidisciplinary approach

Sickle cell retinopathy: improving care with a multidisciplinary approach

Sickle cell retinopathy: A literature review

Complicações Da Síndrome Falciforme

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