2020
DOI: 10.1007/s12602-020-09664-5
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Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment

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Cited by 13 publications
(18 citation statements)
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“… 38 In addition, Streptococcus salivarius is an early colonizer in the oral cavity, which also can colonize the intestinal tract, down-regulate the nuclear transcription factor NF-кB of small intestinal epithelial cells and participate in the process of intestinal inflammation and homeostasis. 39 Through population surveys, it is found that poor oral care behaviors related to alteration of the oral flora, cause an imbalance of intestinal microbes, and lead to the occurrence of IBD. 40 Cariogenic bacteria can also participate in intestinal inflammation.…”
Section: Oral Microbes and Digestive System Diseasesmentioning
confidence: 99%
“… 38 In addition, Streptococcus salivarius is an early colonizer in the oral cavity, which also can colonize the intestinal tract, down-regulate the nuclear transcription factor NF-кB of small intestinal epithelial cells and participate in the process of intestinal inflammation and homeostasis. 39 Through population surveys, it is found that poor oral care behaviors related to alteration of the oral flora, cause an imbalance of intestinal microbes, and lead to the occurrence of IBD. 40 Cariogenic bacteria can also participate in intestinal inflammation.…”
Section: Oral Microbes and Digestive System Diseasesmentioning
confidence: 99%
“…lactis ), and S. thermophilus BT01 induced a salivary IFN-γ reduction trend in symptomatic OLP patients, even though the difference was not significant with respect to the controls [ 140 ]. In an in vitro study, Li and collaborators observed that treatment with Streptococcus salivarius ATCC BAA-2593 supernatant of human squamous carcinoma HSC-3 cell line significantly reduced IL-6 expression; a decreased tendency was observed for IL-1β, IL-8 and TNF-α, showing an NF-kB pathway inhibition [ 22 ].…”
Section: Probiotic Effects On Cytokine/mmp-mediated Signalling Pathwaysmentioning
confidence: 99%
“…OLP treatment mainly takes advantage of the use of corticosteroids, retinoids and 0.1% tacrolimus, especially for the control of the inflammatory symptoms [ 22 , 23 , 24 ]. Nevertheless, there is still the need to undertake more detailed, controlled, and comparative clinical studies to determine the balance between benefits and adverse effects after long-term therapy and to discover newly tailored, safer, and specific measures.…”
Section: Introductionmentioning
confidence: 99%
“…Among these, K12 strain seems to be very interesting: it derives from Streptococcus salvarius , and it was firstly used against Streptococcus pyogenes infections and subsequently suggested for a great number of indications; a large amount of research has, in fact, confirmed its efficacy to treat pharyngitis [ 88 ], tonsillitis, and otitis both in children and adults [ 89 , 90 ], in periodontitis [ 91 ] and to eliminate halitosis [ 92 ]; moreover, a very recent study suggested its successful employment in the treatment of Oral Lichen Planus [ 93 ].…”
Section: Future Perspectivesmentioning
confidence: 99%