Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura

Chen, Can; Yan, Manyun; Yu, Yang; Ke, Jun; Xu, Chang; Guo, Xiaoning; Lu, Haifeng; Wang, Ximing; Hu, Lan; Wang, Jingwen; Ni, Jielei; Zhao, Hongru

doi:10.1007/s10916-019-1425-z

Cited by 31 publications

(39 citation statements)

References 34 publications

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“…Thus, with accumulation of more sessions, the cumulative modulating therapeutic effect of acupuncture can better promote the rehabilitation of migraine from more aspects, which seen on fMRI becomes more extensive and significant than the immediate effect. Pervious study observed that frequent episodic migraine showed decreased ReHo value in the angular gyrus than infrequent episodic migraine group (44). Although, the angular gyrus only showed significant increase after the 12th sessions of acupuncture and no such decrease at baseline, this may be caused by small sample sizes and days of migraine attack were relatively low which need further studies with larger sample size and larger ranges of migraine attack frequency to confirm these results.…”

Section: Discussionmentioning

confidence: 89%

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

et al. 2021

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Introduction: Migraine is a recurrent neurological disorder, the symptoms of which can be significantly relieved by acupuncture. However, the central mechanism via which acupuncture exerts its therapeutic effect in migraine is unclear. The aim of this study was to compare the differences in regional homogeneity (ReHo) between patients with migraine without aura (MwoA) and healthy controls (HCs) and to explore the immediate and cumulative therapeutic effect of acupuncture in patients with MwoA using resting-state functional magnetic resonance imaging (fMRI).Methods: The study subjects were 40 patients with MwoA and 16 matched HCs. The patients with MwoA received acupuncture on 2 days per week for 6 weeks for a total of 12 sessions followed by 24 weeks of follow-up. The primary clinical efficacy outcomes were the number of days with migraine and the average severity of headache. Secondary outcomes were the Migraine-Specific Quality of Life Questionnaire, Self-Rating Anxiety Scale, and Self-Rating Depression Scale scores. In the migraine group, resting-state blood-oxygen-level-dependent fMRI scans were obtained at baseline and after the first and 12th acupuncture sessions to measure the ReHo value. In the HCs, only a baseline resting-state blood-oxygen-level-dependent fMRI scan was obtained.Results: Compared with the control group, the migraine group had a significantly lower ReHo value in the cerebellum, which increased after the first acupuncture session. Long-term acupuncture significantly improved migraine symptoms and mood with a therapeutic effect that lasted for at least 6 months. After 12 acupuncture sessions, there were significant increase of cerebellum and angular gyrus in the migraine group.Conclusion: These findings suggest that migraine is related to cerebellar dysfunction. Acupuncture can relieve the symptoms of migraine, improve dysfunction of cerebellum, and activate brain regions involved in modulation of pain and emotion The cumulative therapeutic effect of acupuncture is more extensive and significant than its immediate effect.

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Section: Discussionmentioning

confidence: 89%

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

et al. 2021

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“…Both Reho and VBM are data-driven analysis methods, reflecting the functional and structural status in vivo. Studies using Reho [31][32][33][34] or VBM [35][36][37][38][39] alone for patients with migraine have been reported. Whole-brain VBM or Reho studies identified widespread functional and volume alternations in migraineurs, specifically in the frontal cortex and limbic systems [31][32][33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

Zhou

Lan

et al. 2020

J Headache Pain

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Objectives To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS). Methods Seventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed. Results Compared with HS, MwoA patients showed decreased volume in the bilateral superior and inferior colliculus, periaqueductal gray matter (PAG), locus ceruleus, median raphe nuclei (MRN) and dorsal pons medulla junction. MwoA patients showed decreased Reho values in the middle occipital gyrus and inferior occipital gyrus, and increased Reho values in the MRN. Only a region in the MRN showed both structural and functional alteration in MwoA patients. Pearson correlation analysis showed that there was no association between volume or Reho values of the MRN and headache frequency, headache intensity, disease duration, self-rating anxiety scale or self-rating depression scale in MwoA patients. Resting state functional connectivity (FC) with the MRN as the seed showed that MwoA patients had increased FC between the MRN and PAG. Conclusions MRN are involved in the pathophysiology of migraine during the interictal period. This study may help to better understand the migraine symptoms. Trial registration NCT01152632. Registered 27 June 2010.

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“…This reduced FC between the left and right hypothalamus and right MFG was significantly positively correlated with headache frequency and headache intensity, respectively. The MFG, as part of the prefrontal cortex that regulates pain perception [ 21 ], has been reportedly involved in both dorsal and ventral attentional networks, responses to fearful expressions, emotional management and the detection of salient behaviorally relevant but task-irrelevant stimuli in patients with migraine compared with controls [ 22 ]. In particular, the MFG is considered to play an important role in the cognitive evaluation and modulation of pain.…”

Section: Discussionmentioning

confidence: 99%

Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury

Wang

et al. 2020

J Headache Pain

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Background Post-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an important factor in pain disorders. However, it is unknown whether there are alterations in the hypothalamus-based resting state FC within PTH following mTBI at the acute stage and its relationship with headache symptom measurement. Methods Forty-four mTBI patients with PTH, 27 mTBI patients without PTH and 43 healthy controls who were well matched for age, gender, and years of education were enrolled in this study. All participants underwent resting-state functional magnetic resonance imaging (fMRI) scanning as well as headache symptom measurement and cognitive assessment. Hypothalamic resting state networks were characterized by using a standard seed-based whole-brain correlation method. The bilateral hypothalamic FC was compared among the three groups. Furthermore, the correlations between hypothalamic resting state networks and headache frequency, headache intensity and MoCA scores was investigated in mTBI patients with PTH using Pearson rank correlation. Results Compared with mTBI patients without PTH, mTBI patients with PTH at the acute stage presented significantly decreased left hypothalamus-based FC with the right middle frontal gyrus (MFG) and right medial superior frontal gyrus (mSFG), and significantly decreased right hypothalamus-based FC with the right MFG. Decreased FC of the right MFG was significantly positively associated with headache frequency and headache intensity ( r = 0.339, p = 0.024; r = 0.408, p = 0.006, respectively). Decreased FC of the right mSFG was significantly positively associated with headache frequency and headache intensity ( r = 0.740, p < 0.0001; r = 0.655, p < 0.0001, respectively). Conclusion Our data provided evidence of disrupted hypothalamic FC in patients with acute mTBI with PTH, while abnormal FC significantly correlated with headache symptom measurement. Taken together, these changes may play an essential role in the neuropathological mechanism of mTBI patients with PTH.

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Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura

Cited by 31 publications

References 34 publications

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury

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