Alterations of calcium and phosphate metabolism in primary hyperparathyroidism during pregnancy

Ammann, Patrick; Irion, Olivier; Gast, Jacques; Bonjour, Jean‐Philippe; Béguin, François; Rizzoli, René

doi:10.3109/00016349309021140

Cited by 17 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Se debe realizar un completo estudio etiológico y categorización de gravedad de la PA, mediante triglicéridos, calcemia total y calcio iónico, perfil bioquímico, hemograma, creatinina, electrolitos plasmáticos, gases arteriales y perfil hepático. En relación a este último es importante tener presente que los niveles de fosfatasas alcalinas se pueden encontrar elevados hasta 3 veces sobre el valor normal durante el embarazo [14][15][16][17] .…”

Section: Discussionunclassified

“…El tratamiento de la PAE secundario a un HPTP se basa en las medidas generales iniciales de soporte que incluyen: reanimación con volumen guiado por metas, la no utilización de antibióticos profilácticos, alimentación oral o enteral temprana, junto con la corrección de los niveles de calcio iónico y decidir la mejor estrategia individualizada para la resolución del HPTP. El cuadro debe ser manejado con una acuciosa valoración individual por un equipo multidisciplinario [15][16][17] .…”

Section: Discussionunclassified

“…La calcitonina (categoría B), a pesar que inhibe la función osteoclástica, no atravesando la barrera placentaria, tiene una baja efectividad y presenta taquifilaxis, limitando su uso rutinario. Los bifosfonatos (categoría C) en estudios animales han evidenciado potencial teratogénico, por lo que se deben restringir en situaciones de HPTP con hipercalcemia grave con riesgo vital 15,16 . cinacalcet (categoría C) es un calcimimético, agonista alostérico de receptores sensibles al calcio paratiroideo, disminuye la producción de PTH, no reportándose complicaciones fetales, usado con precaución y valorado individualmente.…”

Section: Discussionunclassified

See 2 more Smart Citations

Pancreatitis aguda por hipercalcemia en el embarazo. Caso clínico

Arnold

Martínez²,

Oksenberg

et al. 2019

Rev. méd. Chile

View full text Add to dashboard Cite

Acute pancreatitis due to hypercalcemia during pregnancy. Report of one case Acute pancreatitis during pregnancy is uncommon and usually associated with gallstones. However other etiologies must be considered. We report a 24 years old woman with a 32 weeks pregnancy consulting for abdominal pain, nausea and vomiting. She had elevated lipase and amylase levels, a corrected serum calcium of 13.1 mg/dl and a serum phosphate of 1.6 mg/dl. A magnetic resonance colangiopancreatography showed an enlarged pancreas with inflammatory changes and a normal Wirsung duct. A parathyroid nodule was found on cervical ultrasonography. The patient was treated initially with cinacalcet with partial response. A parathyroidectomy was performed at 39 weeks of pregnancy with a good maternal and fetal evolution. (Rev Med Chile 2019; 147: 1078-1081

show abstract

Section: Discussionunclassified

See 1 more Smart Citation

Pancreatitis aguda por hipercalcemia en el embarazo. Caso clínico

Arnold

Martínez²,

Oksenberg

et al. 2019

Rev. méd. Chile

View full text Add to dashboard Cite

show abstract

“…For this review of the literature, we identified 137 case reports with 269 total cases of hyperparathyroidism in pregnancy with the earliest case report published in 1947. There were 85 cases with a single report and 32 case series with the numbers of cases reported varying from 2 to 28 patients in each case report 1,3,5,10–143 …”

Section: Etiology Prevalence and Backgroundmentioning

confidence: 99%

Hyperparathyroidism in Pregnancy: A Review of the Literature

Strebeck¹,

Schneider²,

Whitcombe³

et al. 2022

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

ImportanceMaternal hyperparathyroidism can be associated with significant maternal and fetal morbidity and fetal mortality. Because the maternal symptoms are typically nonspecific, the disorder may not be recognized leading to adverse pregnancy outcomes.ObjectiveThe aim of this study was to review the literature on the etiology/prevalence, pathophysiology, diagnosis, management (medical and surgical), and the maternal/neonatal complications associated with pregnancies complicated by hyperparathyroidism.Evidence AcquisitionA literature search was undertaken by our university librarian using the search engines PubMed and Web of Science. Search terms used included “hyperparathyroidism” AND “pregnancy” OR “pregnancy complications” OR “maternal.” The number of years searched was not limited, but the abstracts had to be in English.ResultsThere were 309 abstracts identified, 164 of which are the basis of this review. This includes 137 articles of the 269 individual case reports in the literature since the first case report in 1947. The articles and case reports reviewed the etiology, risk factors, diagnosis, management, complications, and maternal/fetal outcomes of pregnancies complicated by hyperparathyroidism.Conclusions and RelevanceUndiagnosed maternal hyperparathyroidism can result in critical maternal and fetal outcomes during pregnancy. This review highlights what is currently known about hyperparathyroidism during pregnancy to increase the awareness of this serious pregnancy disorder.Target AudienceObstetricians and gynecologists, and family physiciansLearning ObjectivesAfter completing this activity, the learner should be better able to identify the causes of hyperparathyroidism in pregnancy; explain its pathophysiology; detect the nonspecific symptoms/conditions; evaluate the medical and surgical management; and describe the maternal and fetal complications.

show abstract

“…A menudo no se diagnostica debido a una presentación asintomática e inespecífica en el 80% de los casos debido a que los cambios fisiológicos del embarazo atenúan los signos clínicos 4 . Su incidencia en mujeres en edad fecunda es de 8/100 000 pacientes por año 5 . Algunas alteraciones fisiológicas propias de la mujer gestante contribuyen a ocultar la hipercalcemia, entre ellas el aumento de la tasa de filtración glomerular y la excreción urinaria de calcio, el incremento del volumen del líquido extracelular, la hipoalbuminemia y la gran demanda fetal de calcio.…”

unclassified