Alterations of cellular aging markers in obsessive–compulsive disorder: mitochondrial DNA copy number and telomere length

Kang, Jee In; Park, Chun Il; Lin, Jue; Kim, Shin Tae; Kim, Hae Won; Kim, Se Joo

doi:10.1503/jpn.200238

Cited by 15 publications

(5 citation statements)

References 62 publications

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“…Mitochondria was principal hub in the regulation of immune and inflammatory responses [ 32 ]. A population-based study for obsessive-compulsive disorder, which was a chronic neuropsychiatric disorder, has reported that the disorder and an increased NLR were associated with mtDNAcn, rather than with LTL [ 33 ]. Furthermore, it has been suggested that inflammatory stress causes an increased reactive oxygen species production and accumulated mtDNA damage, and the interaction between oxidative stress and mitochondrial dysfunction can result in energetic failure and death, biological aging, and the pathogenesis of age-related diseases [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Liu

Huang

et al. 2023

Immun Ageing

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Background Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) might mediate the relationship between inflammation and MCI risk. The purpose of the present study is to evaluate whether inflammatory potential of diet assessed by dietary inflammatory index (DII), chronic inflammation, peripheral blood LTL, and mtDNAcn were associated with the risk of MCI. Results A population-based cohort study was conducted with a total of 2944 participants. During a median follow-up of 2 years, 438 (14.90%) individuals were new-onset MCI. After adjustment, a higher score of DII (hazard ratio [HR]: 1.056, 95% CI: 1.005, 1.109), a higher log systemic immune inflammation index (SII) (HR: 1.333, 95% CI: 1.089, 1.633) and log system inflammation response index (SIRI) (HR: 1.487, 95% CI: 1.024, 2.161) predicted elevated risk of MCI. An increased mtDNAcn (HR: 0.843, 95% CI: 0.712, 0.997), but not LTL, predicted a decreased risk of MCI. Negative associations of log SII with LTL (β:-0.359, 95% CI: -0.445, -0.273) and mtDNAcn (β:-0.048, 95% CI: -0.090, -0.006) were found. Additionally, negative associations of log SIRI with LTL (β: -0.035, 95% CI: -0.052, -0.017) and mtDNAcn (β:-0.136, 95% CI: -0.216, -0.056) were also found. Path analysis suggested that SIRI, LTL, and mtDNAcn, in series, have mediation roles in the association between DII score and MCI risk. Conclusions Higher DII, SII, and SIRI might predict a greater risk of MCI, while a longer LTL and an increased mtDNAcn were linked to a reduced risk of MCI among the older population. LTL and mtDNAcn could play mediation roles in the association between DII and MCI risk.

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Section: Discussionmentioning

confidence: 99%

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Liu

Huang

et al. 2023

Immun Ageing

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“…These results were replicated in a tandem (combined) analysis of the telomere content and leukocyte mtDNA copies in young and middle-aged individuals [43,44]. More significant correlation was observed in groups of patients with signs of psychiatric or developmental disorders [45].…”

Section: Non-inclusion Criteriamentioning

confidence: 66%

“…Controversial data 2 on telomere length in schizophrenia relative to healthy controls has been reported in the literature, but the results of meta-analyses [ 19 , 41 ] demonstrate a significant telomer shortening in young patients with schizophrenia spectrum disorders [ 42 ]. These results were replicated in a tandem (combined) analysis of the telomere content and leukocyte mtDNA copies in young and middle-aged individuals [ 43 , 44 ]. More significant correlation was observed in groups of patients with signs of psychiatric or developmental disorders [ 45 ].…”

Section: Introductionmentioning

confidence: 82%

Telomere Length as a Marker of Suicidal Risk in Schizophrenia

Zakharova¹,

Bravve²,

Mamedova³

et al. 2022

Consortium Psychiatricum

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Schizophrenia and suicidal behavior are associated with shortening of telomere length. The aim of the study was to compare the content (pg/g) of the telomeric repeat in DNA isolated from peripheral blood cells in three groups of subjects: patients with schizophrenia and a history of suicide, patients with schizophrenia without suicide, and healthy control volunteers. Material and methods 47 patients with schizophrenia with suicidal behavior, 47 patients without self-destructive tendencies and 47 healthy control volunteers were examined clinically and for the content of telomere repeat in the DNA of blood leukocytes matched by sex and age. Results Analysis of the determination of the telomere repeat (TR) content in DNA indicates a statistically significant increase in telomere length in the series: patients with schizophrenia and suicides - patients with schizophrenia without suicides - healthy controls (225 vs 224 vs 255; p = 0.024). The same trend is observed for the concentration of mitochondrial DNA (mtDNA) (257 vs 262 vs 272; p = 0.012). Conclusions: first established the phenomenon of telomere shortening in schizophrenia associated with suicidal risk. Telomere length corresponds to the parameters of a biological marker - an objectively measured indicator of normal or pathological processes, but its validity still needs to be verified with an assessment of its sensitivity, specificity, positive and negative predictive value. It is premature to consider telomere length as a predictive indicator of suicidal risk.

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“…Previous observational studies have given little attention to OCD in older adults. Some studies suggest that individuals with OCD experience accelerated brain aging, as well as shortening of mitochondrial DNA copy number (mtDNAcn) and telomere length in the blood ( 44 , 45 ). However, our study did not observe a bidirectional relationship between FI and OCD.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional causal relational between frailty and mental illness: a two-sample Mendelian randomization study

Ma,

Liu,

et al. 2024

Front. Psychiatry

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BackgroundFrailty has been associated with mental illness (MI) observational studies, but the causal relationship between these factors remains uncertain. We aimed to assess the bidirectional causality between frailty and MI by two-sample Mendelian randomization (MR) analyses.MethodsTo investigate the causal relationship among them, summary statistics of frailty index (FI) and six types of MI: anxiety, depression, affective disorder, mania, schizophrenia, and obsessive-compulsive disorder (OCD) were included in this MR study. This MR analysis was performed using inverse variance weighting (IVW), MR-Egger regression, and weighted median. The stability of the results was evaluated using Cochran’s Q test, MR-Egger intercept test, Funnel Plots, and leave-one-out analysis.ResultsGenetic predisposition to FI was significantly associated with increased anxiety (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.13-2.33, P = 8.18E-03), depression (OR = 1.88, 95% CI 1.30-2.71, P = 8.21E-04), affective disorder (OR = 1.70, 95% CI 1.28-2.27, P = 2.57E-04). However, our study findings do not demonstrate a causal relationship between FI and mania (OR = 1.02, 95% CI 0.99-1.06, P = 2.20E-01), schizophrenia (OR = 1.02, 95% CI 0.07-0.86, P = 9.28E-01). In particular, although the IVW results suggest a potential causal relationship between FI and OCD (OR = 0.64, 95% CI 0.07-0.86, P = 2.85E-02), the directions obtained from the three methods we employed ultimately show inconsistency. Therefore, the result must be interpreted with caution. The results of the reverse MR analysis indicated a statistically significant and causal relationship between anxiety (OR = 1.06, 95% CI 1.01-1.11, P = 2.00E-02), depression (OR = 1.14, 95% CI 1.04-1.26, P = 7.99E-03), affective disorder (OR = 1.15, 95% CI 1.09-1.21, P = 3.39E-07), and schizophrenia (OR = 1.02, 95% CI 1.01-1.04, P = 1.70E-03) with FI. However, our findings do not provide support for a link between mania (OR = 1.46, 95% CI 0.79-2.72, P = 2.27E-01), OCD (OR = 1.01, 95% CI 1.00-1.02, P = 2.11E-01) and an increased risk of FI.ConclusionThe MR results suggest a potential bidirectional causal relationship between FI and anxiety, depression, and affective disorder. Schizophrenia was found to be associated with a higher risk of FI. The evidence was insufficient to support a causal relationship between Fl and other Ml. These findings offer new insights into the development of effective management strategies for frailty and MI.

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Alterations of cellular aging markers in obsessive–compulsive disorder: mitochondrial DNA copy number and telomere length

Cited by 15 publications

References 62 publications

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Telomere Length as a Marker of Suicidal Risk in Schizophrenia

Bidirectional causal relational between frailty and mental illness: a two-sample Mendelian randomization study

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