Alterations of GABA and glutamate–glutamine levels in premenstrual dysphoric disorder: A 3T proton magnetic resonance spectroscopy study

Liu, Bo; Wang, Guangbin; Gao, Dongmei; Gao, Fei; Zhao, Bin; Qiao, Mingqi; Yang, Huan; Yu, Yang; Ren, Fuxin; Yang, Ping; Chen, Weibo; Rae, Caroline

doi:10.1016/j.pscychresns.2014.10.020

Cited by 46 publications

(35 citation statements)

References 61 publications

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“…However, reliable quantification of Glu and Gln has proven to be challenging given the low editing efficiency of Glu and Gln in this acquisition method. Some studies have quantified the peak at 3.75 ppm as Glx (the sum of Glu + Gln) . This approach is incapable of evaluating Glu and Gln separately and is not useful in conditions in which the Glu and Gln concentration change in opposite directions.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have quantified the peak at 3.75 ppm as Glx (the sum of Glu + Gln). [19][20][21][22] This approach is incapable of evaluating Glu and Gln separately and is not useful in conditions in which the Glu and Gln concentration change in opposite directions. Some studies have reported Glu concentrations using LCModel software 16,23 ; however, these studies fall short in quantifying Gln and cannot investigate the precision of Glu estimation.…”

mentioning

confidence: 99%

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Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA‐edited MEGA‐PRESS

et al. 2017

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γ‐Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher–Garwood point‐resolved spectroscopy (MEGA‐PRESS). In a GABA‐edited MEGA‐PRESS spectrum, Glu and Gln co‐edit with GABA, providing the possibility to measure all three in one acquisition. In this study, we investigated the reliability of the composite Glu + Gln (Glx) peak estimation and the possibility of Glu and Gln separation in GABA‐edited MEGA‐PRESS spectra. The data acquired in vivo were used to develop a quality assessment framework which identified MEGA‐PRESS spectra in which Glu and Gln could be estimated reliably. Phantoms containing Glu, Gln, GABA and N‐acetylaspartate (NAA) at different concentrations were scanned using GABA‐edited MEGA‐PRESS at 3 T. Fifty‐six sets of spectra in five brain regions were acquired from 36 healthy volunteers. Based on the Glu/Gln ratio, data were classified as either within or outside the physiological range. A peak‐by‐peak quality assessment was performed on all data to investigate whether quality metrics can discriminate between these two classes of spectra. The quality metrics were as follows: the GABA signal‐to‐noise ratio, the NAA linewidth and the Glx Cramer–Rao lower bound (CRLB). The Glu and Gln concentrations were estimated with precision across all phantoms with a linear relationship between the measured and true concentrations: R 1 = 0.95 for Glu and R 1 = 0.91 for Gln. A quality assessment framework was set based on the criteria necessary for a good GABA‐edited MEGA‐PRESS spectrum. Simultaneous criteria of NAA linewidth <8 Hz and Glx CRLB <16% were defined as optimum features for reliable Glu and Gln quantification. Glu and Gln can be reliably quantified from GABA‐edited MEGA‐PRESS acquisitions. However, this reliability should be controlled using the quality assessment methods suggested in this work.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA‐edited MEGA‐PRESS

et al. 2017

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“…Women with PMDD showed an increase in cortical GABA from the follicular to the luteal phases, while control women showed a decrease in cortical GABA from follicular to luteal, further evidence of altered GABAergic function in PMDD, and perhaps an aberrant interaction between ALLO and GABA in the central nervous system [69]. More recent work showed significantly lower GABA concentrations in the anterior cingulate cortex, medial prefrontal cortex, and left basal ganglia of women with PMDD [70••]. Women with PMDD had lower activation of the pregenual anterior cingulate and ventromedial prefrontal cortex across the menstrual cycle [42••].…”

Section: Research Tools Applied To Pmddmentioning

confidence: 99%

Premenstrual Dysphoric Disorder: Epidemiology and Treatment

Hantsoo¹,

Epperson²

2015

Curr Psychiatry Rep

235

147

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Recently designated as a disorder in the DSM-5, premenstrual dysphoric disorder (PMDD) presents an array of avenues for further research. PMDD's profile, characterized by cognitive–affective symptoms during the premenstruum, is unique from that of other affective disorders in its symptoms and cyclicity. Neurosteroids may be a key contributor to PMDD's clinical presentation and etiology, and represent a potential avenue for drug development. This review will present recent literature on potential contributors to PMDD's pathophysiology, including neurosteroids and stress, and explore potential treatment targets.

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“…Importantly, interactions with the serotonergic [90,94] and the GABAergic system [85••, 95], as well as with glutamate-glutamine [95] and myo-inositol-creatine [88], have been suggested in PMDD patients. Hypothesis-driven volume of interest (VOI)-based statistical analyses and scattered results call for well-powered studies including more than 20 subjects and considering if the magnitude of changes observed between different hormonal conditions is bigger than the one previously reported in test-retest variability.…”

Section: Brain Chemistrymentioning

confidence: 99%

Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder

Comasco

Sundström‐Poromaa

2015

Curr Psychiatry Rep

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Knowledge of gonadal hormone-related influences on human brain anatomy, function, and chemistry is scarce. The present review scrutinized organizational and functional neuroimaging correlates of the menstrual cycle and premenstrual dysphoric disorder (PMDD). Supportive evidence of cyclic short-term structural and functional brain plasticity in response to gonadal hormonal modulation is provided. The paucity of studies, sparsity and discordance of findings, and weaknesses in study design at present hinder the drawing of firm conclusions. Ideal study designs should comprise high-resolution multimodal neuroimaging (e.g., MRI, DTI, rs-fMRI, fMRI, PET), hormones, genetic, and behavioral longitudinal assessments of healthy women and PMDD patients at critical time points of the menstrual cycle phase (i.e., early follicular phase, late follicular phase, mid-luteal phase) in a counter-balanced setup. Studies integrating large-scale brain network structural, functional, and molecular neuroimaging, as well as treatment data, will deepen the understanding of neural state, disorder, and treatment markers.

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Alterations of GABA and glutamate–glutamine levels in premenstrual dysphoric disorder: A 3T proton magnetic resonance spectroscopy study

Cited by 46 publications

References 61 publications

Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA‐edited MEGA‐PRESS

Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA‐edited MEGA‐PRESS

Premenstrual Dysphoric Disorder: Epidemiology and Treatment

Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder

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