Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia

Lu, Jia; M, Fu; Tian, Ying; Xu, Yu; Gou, Lantu; Tian, Haoming; Tian, Li

doi:10.1016/j.ijcard.2006.10.007

Cited by 15 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common hyperlipidemia in the general population and, in particular, in subjects with cardiovascular disease is combined dyslipidemia. 35 This could be partly related to a different distribution less effective HDL subclasses, 36 but also to other factors In this study, carried out on subjects affected by acquired mixed dyslipidemia, we observed that the serum levels of MMP-2, MMP-9 and their tissue inhibitors are macroscopically higher than in control subjects. In particular, MMP-2 is doubled and TIMP-1 tripled, MMP-9 is 10 times higher than controls, while TIMP-2 increased by 30%.…”

Section: Discussionmentioning

confidence: 62%

Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia

Derosa

Maffioli

D’Angelo

et al. 2009

CIM

View full text Add to dashboard Cite

Clin Invest Med 2009; 32 (2): E124-E132. AbstractPurpose: To evaluate the distribution of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their specific inhibitors in a sample of patients affected by mild dyslipidemia but not yet treated with antihyperlipidemic drugs. Methods: One hundred and sixty-eight Caucasian patients aged 18 yr of either sex with combined dyslipidemia and who had never previously taken lipid-lowering medications were evaluated. As a control population, we enrolled 179 Caucasian healthy subjects, aged 18 yr of either sex. We evaluated body mass index (BMI), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) Lp(a), plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high sensitivity Creactive protein (Hs-CRP), adiponectin (ADP), MMP-2, MMP-9, tissue inhibitors of metalloproteinase-1 (TIMP-1), and tissue inhibitors of metalloproteinase-2 (TIMP-2). Results: TC, Tg, and LDL-C were higher (P << 0.05, P << 0.01 and P << 0.05, respectively) in the dyslipidemic group, while HDL-C levels were lower (P << 0.01) compared with the control group. Increases of PAI-1, Hct, Fg, and Hs-CRP (P << 0.01, P << 0.05, P << 0.05, and P << 0.05, respectively) were present in the dyslipidemic group, while ADP level was lower (P << 0.01) in the dyslipidemic patients compared with controls. MMP-2, MMP-9, TIMP-1, and TIMP-2 levels were higher (P << 0.0001) in the dyslipidemic group. Conclusions: Combined hyperlipidemic patients have increased levels of prothrombotic and microinflammatory parameters and higher levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 than control subjects. The prognostic importance of this observation has to be evaluated in adequately designed prospective studies. List of Abbreviations

show abstract

Section: Discussionmentioning

confidence: 62%

Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia

Derosa

Maffioli

D’Angelo

et al. 2009

CIM

View full text Add to dashboard Cite

show abstract

“…Regardless of in CHD patients with or without diabetes, the mean levels of plasma lipids, and lipoproteins were normal or desirable(as defined by the NCEP ATP-III guidelines) except the TG levels were border-line high and HDL-C levels were low for CHD patients with diabetes; whereas the contents of HDL 2b+preβ2 (389.3 mg/L) were significantly lower for the CHD patients without diabetes than HDL 2b added preβ 2 -HDL contents (378.4 + 56.0 = 434.4 mg/L) for normolipidemic subjects [24]. Unlike this, we have previously investigated the plasma HDL subclasses distribution in hyperlipidemic, obese, primary diabetic mellitus (DM), and CHD patients [22,23,25-27].…”

Section: Discussionmentioning

confidence: 99%

High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes

Tian

Long

et al. 2012

Lipids Health Dis

Self Cite

View full text Add to dashboard Cite

BackgroundA higher prevalence of coronary heart disease (CHD) in people with diabetes. We investigated the high-density lipoprotein (HDL) subclass profiles and alterations of particle size in CHD patients with diabetes or without diabetes.MethodsPlasma HDL subclasses were quantified in CHD by 1-dimensional gel electrophoresis coupled with immunodetection.ResultsAlthough the particle size of HDL tend to small, the mean levels of low density lipoprotein cholesterol(LDL-C) and total cholesterol (TC) have achieved normal or desirable for CHD patients with or without diabetes who administered statins therapy. Fasting plasma glucose (FPG), triglyceride (TG), TC, LDL-C concentrations, and HDL3 (HDL3b and 3a) contents along with Gensini Score were significantly higher; but those of HDL-C, HDL2b+preβ2, and HDL2a were significantly lower in CHD patients with diabetes versus CHD patients without diabetes; The preβ1-HDL contents did not differ significantly between these groups. Multivariate regression analysis revealed that Gensini Score was significantly and independently predicted by HDL2a, and HDL2b+preβ2.ConclusionsThe abnormality of HDL subpopulations distribution and particle size may contribute to CHD risk in diabetes patients. The HDL subclasses distribution may help in severity of coronary artery and risk stratification, especially in CHD patients with therapeutic LDL, TG and HDL levels.

show abstract

“…The findings demonstrated that plasma increased TG and TC concentrations cause the particles size of HDL subclasses tend to smaller, creating an environment of diminished reverse cholesterol reverse cholesterol transport(RCT)[12,16-18]. The elevated TG levels are usually not only accompanied by other lipid metabolic disturbance but also associated with the change in plasma apolipoprotein levels.…”

Section: Introductionmentioning

confidence: 99%

The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution

Tian

Xu²,

et al. 2011

Lipids Health Dis

Self Cite

View full text Add to dashboard Cite

ObjectiveTo investigate the effect of triglyceride (TG) integrates with plasma major components of apolipoproteins in HDL subclasses distribution and further elicited the TG-apolipoproteins (apos) interaction in the processes of high density lipoprotein (HDL) mature metabolic and atherosclerosis related diseases.MethodsContents of plasma HDL subclasses were quantities by two-dimensional gel electrophoresis associated with immunodetection in 500 Chinese subjects.ResultsContents of preβ1-HDL, HDL3a, and apoB-100 level along with apoB-100/A-I ratio were significantly increased, whereas there was a significant reduction in the contents of HDL2, apoA-I level as well as apoC-III/C-II ratio with increased TG concentration. Moreover, preβ1-HDL contents is elevated about 9 mg/L and HDL2b contents can be reduced 21 mg/L for 0.5 mmol/L increment in TG concentration. Moreover, with increase of apoA-I levels, HDL2b contents were marginally elevated in any TG concentration group. Furthermore, despite of in the apoB-100/A-I < 0.9 group, the contents of preβ1-HDL increased, and those of HDL2b decreased significantly for subjects in both high and very high TG levels compared to that in normal TG levels. Similarly, in the apoB-100/A-I ≥ 0.9 group, the distribution of HDL subclasses also showed abnormality for subjects with normal TG levels.ConclusionsThe particle size of HDL subclasses tend to small with TG levels increased which indicated that HDL maturation might be impeded and efficiency of reverse cholesterol transport(RCT) might be weakened. These data suggest that TG levels were not only significantly associated with but liner with the contents of preβ1-HDL and HDL2b. They also raise the possibility that the TG levels effect on HDL maturation metabolism are subjected to plasma apolipoproteins and apolipoproteins ratios.

show abstract

Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia

Cited by 15 publications

References 41 publications

Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia

Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia

High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes

The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution

Contact Info

Product

Resources

About