Alterations of putaminal shape in de novo Parkinson's disease

Caligiuri, Maria Eugenia; Nisticò, Rita; Arabia, Gennarina; Morelli, Maurizio; Novellino, Fabiana; Salsone, Maria; Barbagallo, Gaetano; Lupo, Angela; Cascini, Giuseppe Lucio; Galea, Domenico; Cherubini, Andrea; Quattrone, Aldo

doi:10.1002/mds.26550

Cited by 15 publications

(14 citation statements)

References 32 publications

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“…In contrast, while shape differences were evident bilaterally for both L-PD and R-PD relative to non-PD peers, contralateral putamen or caudate nuclei generally showed larger areas of atrophy (see Table 3). This result thus matches previous morphometric research (11, 12) and demonstrates the limitations of assessing asymmetry using traditional volumetrics (2). That there were also ipsilateral shape differences was expected because of the mean disease duration and manifestation of bilateral clinical symptoms.…”

Section: Discussionsupporting

confidence: 90%

“…Taken together, our results demonstrate greater contralateral striatal atrophy relative to side of motor onset in PD and a medial-to-lateral progression of atrophy within the striatum (12). An alternative interpretation is that the medial sides of the putamen and caudate nucleus might be the sides of the structures that shift with neurodegeneration.…”

Section: Discussionsupporting

confidence: 59%

“…Two studies (11, 12) additionally addressed symptom laterality and lateralized atrophy with the suggestion that there were greater contralateral than ipsilateral shape changes in PD, but the results could benefit from replication with larger samples. An additional limitation of previous studies is that while atrophy of the hippocampus and related medial temporal lobe cortex are reported as common features in PD (7, 8, 19, 20), morphometric studies have either not addressed (11, 13, 16, 17) or found (3, 12, 14, 15, 18, 21) hippocampal shape differences.…”

Section: Introductionmentioning

confidence: 99%

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Striatal and Hippocampal Atrophy in Idiopathic Parkinson’s Disease Patients without Dementia: A Morphometric Analysis

2017

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BackgroundAnalyses of subcortical gray structure volumes in non-demented idiopathic Parkinson’s disease (PD) often, but not always, show volume loss of the putamen, caudate nucleus, nucleus accumbens, and hippocampus. There is building evidence that structure morphometry might be more sensitive to disease-related processes than volume.ObjectiveTo assess morphometric differences of subcortical structures (putamen, caudate nucleus, thalamus, globus pallidus, nucleus accumbens, and amygdala) as well as the hippocampus in non-demented individuals with PD relative to age and education matched non-PD peers.MethodsProspective recruitment of idiopathic no-dementia PD and non-PD peers as part of a federally funded investigation. T1-weighted isovoxel metrics acquired via 3-T Siemens Verio for all individuals [PD n = 72 (left side onset n = 27, right side onset n = 45); non-PD n = 48]. FIRST (FMRIB Software Library) applications provided volumetric and vertex analyses on group differences for structure size and morphometry.ResultsGroup volume differences were observed only for putamen and hippocampi (PD < non-PD) with hippocampal volume significantly associating with disease duration. Group shape differences were observed for bilateral putamen, caudate nucleus, and hippocampus with greater striatal atrophy contralateral to side of motor symptom onset. Hippocampal shape differences disappeared when removing the effects of volume.ConclusionThe putamen was the primary structure to show both volume and shape differences in PD, indicating that the putamen is the predominant site of basal ganglia atrophy in early- to mid-stage PD. Side of PD symptom onset associates with contralateral striatal atrophy. Left-onset PD might experience more extensive striatal atrophy than right-onset PD. Hippocampus morphometric results suggest possible primary atrophy of CA3/4 and dentate gyrus.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

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Striatal and Hippocampal Atrophy in Idiopathic Parkinson’s Disease Patients without Dementia: A Morphometric Analysis

2017

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“…There is a need for longitudinal in vivo MRI research to present clear rates of atrophy and clinical relevance by structure in PD. Compared to previous research demonstrating greater contralateral subcortical morphometric changes in PD (Sterling et al, 2013; Caligiuri et al, 2016), MN’s baseline brain structure asymmetry and accelerated atrophy of the right caudate nucleus are highly unusual.…”

Section: Discussioncontrasting

confidence: 77%

“…There is evidence that individuals with PD have bilateral basal ganglia volume loss regardless of side of onset (Geng, Li, & Zee, 2006) with the putamen the primarily affected structure (Price et al, 2016; Garg et al, 2015; Nemmi et al, 2015). Using shape (morphometric) analyses of subcortical gray matter structures, however, provides evidence of greater contralateral than ipsilateral shape changes in PD for both the putamen and caudate nucleus (Sterling et al, 2013; Caligiuri et al, 2016; Lee et al, 2014). Further, using brain diffusion tensor imaging metrics, it is possible to differentiate between right and left onset PD (Feis, Pelzer, Timmermann, Tittgemeyer, 2013).…”

Section: Introductionmentioning

confidence: 99%

Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson’s disease: a longitudinal analysis

Tanner

Levy

Schwab

et al. 2016

The Clinical Neuropsychologist

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Objective A 71-year old (MN) with an 11-year history of left onset tremor diagnosed as Parkinson’s disease (PD) completed longitudinal brain magnetic resonance imaging (MRI) and neuropsychological testing. MRI scans showed an asymmetric caudate nucleus (right< left volume). We describe this asymmetry at baseline and the progression over time relative to other subcortical gray, frontal white matter, and cortical gray matter regions of interest. Isolated structural changes are compared to MN’s cognitive profiles. Method MN completed yearly MRIs and neuropsychological assessments. For comparison, left onset PD (n=15) and non-PD (n=43) peers completed the same baseline protocol. All MRI scans were processed with FreeSurfer and the FMRIB Software Library (FSL) to analyze gray matter structures and frontal fractional anisotropy (FA) metrics. Processing speed, working memory, language, verbal memory, abstract reasoning, visuospatial, and motor functions were examined using reliable change methods. Results At baseline MN had striatal volume and frontal lobe thickness asymmetry relative to peers with mild prefrontal white matter FA asymmetry. Over time only MN’s right caudate nucleus showed accelerated atrophy. Cognitively, MN had slowed psychomotor speed and visuospatial-linked deficits with mild visuospatial working memory declines longitudinally. Conclusions This is a unique report using normative neuroimaging and neuropsychology to describe an individual diagnosed with PD who had striking striatal asymmetry followed secondarily by cortical thickness asymmetry and possible frontal white matter asymmetry. His decline and variability in visual working memory could be linked to ongoing atrophy of his right caudate nucleus.

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Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease

et al. 2019

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A BS TRACT: Background: Whether structural alterations underpin apathy and depression in de novo parkinsonian patients is unknown. The objectives of this study were to investigate whether apathy and depression in de novo parkinsonian patients are related to structural alterations and how structural abnormalities relate to serotonergic or dopaminergic dysfunction. Methods: We compared the morphological and microstructural architecture in gray matter using voxel-based morphometry and diffusion tensor imaging coupled with white matter tract-based spatial statistics in a multimodal imaging case-control study enrolling 14 apathetic and 13 nonapathetic patients with de novo Parkinson's disease and 15 agematched healthy controls, paired with PET imaging of the presynaptic dopaminergic and serotonergic systems. Results: De novo parkinsonian patients with apathy had bilateral microstructural alterations in the medial corticostriatal limbic system, exhibiting decreased fractional anisotropy and increased mean diffusivity in the anterior striatum and pregenual anterior cingulate cortex in conjunction with serotonergic dysfunction. Furthermore, microstructural alterations extended to the medial frontal cortex, the subgenual anterior cingulate cortex and subcallosal gyrus, the medial thalamus, and the caudal midbrain, suggesting disruption of long-range nondopaminergic projections originating in the brainstem, in addition to microstructural alterations in callosal interhemispheric connections and frontostriatal association tracts early in the disease course. In addition, microstructural abnormalities related to depressive symptoms in apathetic and nonapathetic patients revealed a distinct, mainly right-sided limbic subnetwork involving limbic and frontal association tracts. Conclusions: Early limbic microstructural alterations specifically related to apathy and depression emphasize the role of early disruption of ascending nondopaminergic projections and related corticocortical and corticosubcortical networks which underpin the variable expression of nonmotor and neuropsychiatric symptoms in Parkinson's disease.

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Alterations of putaminal shape in de novo Parkinson's disease

Abstract: Shape analysis in de novo-PD patients suggested a progressive medial-to-lateral involvement of the putamina that paralleled an asymmetric-to-bilateral distribution of DA transporter depletion. © 2016 International Parkinson and Movement Disorder Society.

Cited by 15 publications

References 32 publications

Striatal and Hippocampal Atrophy in Idiopathic Parkinson’s Disease Patients without Dementia: A Morphometric Analysis

Striatal and Hippocampal Atrophy in Idiopathic Parkinson’s Disease Patients without Dementia: A Morphometric Analysis

Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson’s disease: a longitudinal analysis

Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease

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