Altered baseline brain activities before food intake in obese men: A resting state fMRI study

Zhang, Bin; Tian, Derun; Yu, Chunshui; Zhang, Jing; Tian, Xin; Deneen, Karen M. von; Zang, Yu‐Feng; Walter, Martin; Liu, Yijun

doi:10.1016/j.neulet.2014.10.020

Cited by 43 publications

(56 citation statements)

References 23 publications

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“…9 In this study, it was demonstrated that obese vs normal-weight males ‘exhibited a higher level of synchronicity of activity in the left putamen prior to food intake' however, in contrast to the main effect of BMI on resting-state activity in the putamen, claustrum and insula in our study, Zhang et al 9 observed differences in resting-state brain activity before, but not after food intake in obese males. There are essential methodological differences between both the studies that could explain these partially discrepant findings.…”

Section: Discussioncontrasting

confidence: 66%

“…Previous studies demonstrated that the gender influenced task-dependent brain activation patterns in regions associated with reward anticipation 3 and brain activation during voluntary inhibition of hunger during food stimulation. 20 This could offer an explanation as to why we found differences in post-prandial resting-state brain activity between BMI groups, whereas the previous study 9 did not. Another factor that could account for the discrepant post-prandial findings between studies concerns the timing of rsfMRI scans.…”

Section: Discussionmentioning

confidence: 52%

“…23 Dopamine signaling has an important role in reward processing of food. 24 Furthermore, it must be kept in mind that the sample size in each of the studies was relatively small and different between the studies (present vs previous study: 17 obese and 12 normal-weight individuals vs 20 individuals in each group 9 ), which may have not only limited power, but could also explain their discrepant rsfMRI results after food intake. Finally, an important difference in study procedures relates to the amount of calories supplied by the test meal (260 kcal vs 40% of resting energy expenditure) and we cannot rule out that a larger caloric preload may have attenuated post-prandial differences in the resting-state activity between BMI groups observed in our study.…”

Section: Discussionmentioning

confidence: 79%

“…8 To our best knowledge, only one study has systematically examined the intrinsic brain activity patterns under both fasting and post-prandial conditions in normal-weight and obese individuals. 9 This study, which included male participants only, reported increased resting-state activity in the putamen, and decreased activity in the orbitofrontal cortex and medial prefrontal cortex compared with normal-weight male controls in a fasted state. In contrast, no such differences were observed after consumption of a liquid formula meal.…”

Section: Introductionmentioning

confidence: 69%

“…The effect of food intake on rsfMRI has so far only investigated in males, 9 but not in females. The present study therefore sought to measure task-independent (intrinsic) low-frequency blood-oxygenation-level-dependent signals of the brain, both before and after food intake in severely obese and normal-weight females.…”

Section: Introductionmentioning

confidence: 99%

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Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake

et al. 2016

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Background:In response to food cues, obese vs normal-weight individuals show greater activation in brain regions involved in the regulation of food intake under both fasted and sated conditions. Putative effects of obesity on task-independent low-frequency blood-oxygenation-level-dependent signals—that is, resting-state brain activity—in the context of food intake are, however, less well studied.Objective:To compare eyes closed, whole-brain low-frequency BOLD signals between severely obese and normal-weight females, as assessed by functional magnetic resonance imaging (fMRI).Methods:Fractional amplitude of low-frequency fluctuations were measured in the morning following an overnight fast in 17 obese (age: 39±11 years, body mass index (BMI): 42.3±4.8 kg m−2) and 12 normal-weight females (age: 36±12 years, BMI: 22.7±1.8 kg m−2), both before and 30 min after consumption of a standardized meal (~260 kcal).Results:Compared with normal-weight controls, obese females had increased low-frequency activity in clusters located in the putamen, claustrum and insula (P<0.05). This group difference was not altered by food intake. Self-reported hunger dropped and plasma glucose concentrations increased after food intake (P<0.05); however, these changes did not differ between the BMI groups.Conclusion:Reward-related brain regions are more active under resting-state conditions in obese than in normal-weight females. This difference was independent of food intake under the experimental settings applied in the current study. Future studies involving males and females, as well as utilizing repeated post-prandial resting-state fMRI scans and various types of meals are needed to further investigate how food intake alters resting-state brain activity in obese humans.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake

et al. 2016

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Enhanced neural responsiveness to reward associated with obesity in the absence of food‐related stimuli

Opel

Redlich

Grotegerd

et al. 2015

Human Brain Mapping

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Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study

Doornweerd

Duinkerken

Geus

et al. 2017

Human Brain Mapping

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Obesity is related to altered functional connectivity of resting state brain networks that are involved in reward and motivation. It is unknown to what extent these associations reflect genetic confounding and whether the obesity-related connectivity changes are associated with differences in dietary intake. In this study, resting state functional MRI was performed after an overnight fast in 16 female monozygotic twin pairs (aged 48.8 ± 9.8 years) with a mean BMI discordance of 3.96 ± 2.1 kg/m (range 0.7-8.2). Functional connectivity of the salience, basal ganglia, default mode and anterior cingulate-orbitofrontal cortex networks was examined by independent component analysis. Dietary intake was assessed using 3-day 24-hour recalls. Results revealed that within the basal ganglia network, heavier versus leaner co-twins have decreased functional connectivity strength in bilateral putamen (P < 0.05, FWE-corrected). There were no differences in connectivity in the other networks examined. In the overall group, lower functional connectivity strength in the left putamen was correlated with higher intake of total fat (P < 0.01). It was concluded that, after eliminating genetic effects, overweight is associated with lower resting state functional connectivity in bilateral putamen in the basal ganglia network. The association between lower putamen connectivity and higher fat intake suggests an important role of the putamen in appetitive mechanisms. The cross-sectional nature of our study cannot discriminate cause and consequence, but the findings are compatible with an effect of lower putamen connectivity on increased BMI and associated higher fat intake. Hum Brain Mapp 38:5069-5081, 2017. © 2017 Wiley Periodicals, Inc.

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Altered baseline brain activities before food intake in obese men: A resting state fMRI study

Cited by 43 publications

References 23 publications

Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake

Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake

Enhanced neural responsiveness to reward associated with obesity in the absence of food‐related stimuli

Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study

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