Altered intrinsic regional brain activity in male patients with severe obstructive sleep apnea: a resting-state functional magnetic resonance imaging study

Peng, Dechang; Dai, Xuesong; Gong, Honghan; Li, Hai-Jun; Nie, Xin; Zhang, Wei

doi:10.2147/ndt.s67805

Cited by 67 publications

(55 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current findings dovetail with a growing literature suggesting that sleep and DMN connectivity are closely linked. Specifically, this study suggests that in addition to sleep deprivation 4,6 , quality 36 , and disorders, such as insomnia and OSA 3,5,20 , greater sleep/wake irregularity may impact network structure within the DMN. Previously, reduced DMN functional connectivity has been proposed as a neural substrate of the behavioral correlates for sleep deprivation 4 and/or may reflect a "local sleep" in which a portion of the brain enters a sleep state when an individual is otherwise conscious 7,55 .…”

Section: Discussionmentioning

confidence: 90%

“…Specifically, prior work has shown that sleep deprivation results in reduced functional connectivity of the DMN and the DMN-ACN anticorrelation during both rest and task performance and among both young and older adults 4,6 . In addition, reduced DMN connectivity has been observed among young and elderly adults who report high levels of daytime sleepiness 7 as well as individuals diagnosed with insomnia and obstructive sleep apnea (OSA) disorders 3,5,20 . Taken together, these studies suggest a close association between sleep and DMN connectivity and highlight a potential neural mechanism by which poor sleep results in cognitive deficits.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults

Lunsford‐Avery

Damme

Engelhard

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Sleep deprivation and disorders are linked to reduced DMn connectivity. Less is known about how naturalistic sleep patterns -specifically sleep irregularity -relate to the DMN, particularly among adolescents and young adults. Additionally, no studies have utilized graph theory analysis to clarify whether sleep-related decreases in connectivity reflect global or local DMN changes. Twenty-five healthy adolescents and young adults (age range = 12-22; mean = 18.08; SD = 2.64, 56% female) completed 7 days of actigraphy and resting-state fMRI. Sleep regularity was captured by the Sleep Regularity Index (SRI) and the relationship between the SRI and DMN was examined using graph theory analysis. Analogous analyses explored relationships between the SRi and additional resting-state networks. Greater sleep regularity related to decreased path length (increased network connectivity) in DMn regions, particularly the right and left lateral parietal lobule, and the Language network, including the left inferior frontal gyrus and the left posterior superior frontal gyrus. findings were robust to covariates including sex and age. Sleep and DMn function may be tightly linked during adolescence and young adulthood, and reduced DMN connectivity may reflect local changes within the network. future studies should assess how this relationship impacts cognitive development and neuropsychiatric outcomes in this age group. open Scientific RepoRtS | (2020) 10:509 | https://doi.complaints are often observed among adolescents with neuropsychiatric conditions, such as ADHD, depression, and emerging psychosis 17,18,[57][58][59][60] , future studies should examine how the interplay between sleep regularity and DMN connectivity and network structure impacts the presentation of these disorders during this developmental period.Indeed, a recent study has shown that poor sleep quality is related to increased impulsivity among adolescents with low, but not high, connectivity between the DMN and prefrontal cortex, suggesting DMN connectivity may contribute to links between sleep and behavioral outcomes in this age group 61 . Additionally, another recent investigation has suggested that greater sleep irregularity, as measured by the SRI, may mediate the relationship between delayed sleep onset time and daytime functioning in work/school, social, and family domains 62 . Finally, exploratory analysis in the current study indicated a relationship between sleep regularity and network structure efficiency within the Language Network, particularly in areas of the left inferior frontal gyrus and the left posterior superior frontal gyrus. Relative to the DMN, very little is known about how sleep may relate to connectivity within this network. However, it is notable that from a behavioral perspective, sleep irregularity in general has been linked to poorer verbal cognition in youth 21 and the SRI specifically is associated with poorer communication among youth with Autism 63 . Future investigations using larger samples of adolescents and young adults should rep...

show abstract

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults

Lunsford‐Avery

Damme

Engelhard

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Previous brain Rs-MRI studies in OSA patients have revealed alterations in cerebellar, frontal, parietal, temporal, thalamic, middle and dorsal prefrontal cortex, left precentral gyrus, and posterior cingulate cortex regions 11–13,16. OSA patients have abnormal Rs-FC in various brain regions that are related to affective, autonomic, sensorimotor, executive, and cognitive regulatory functions 11.…”

Section: Discussionmentioning

confidence: 99%

Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI

Chen¹,

Fan²,

Li³

et al. 2017

NDT

Self Cite

View full text Add to dashboard Cite

PurposeObstructive sleep apnea (OSA) is a common sleep-related breathing disorder that can damage cognitive function. However, the functional network organization remains poorly understood. The aim of this study was to investigate the topological properties of OSA patients using a graph theoretical analysis.Patients and methodsA total of 30 male patients with untreated severe OSA and 25 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (MRI) examinations. Clinical and cognitive evaluations were conducted by an experienced psychologist. GRETNA (a toolbox for topological analysis of imaging connectomics) was used to construct the brain functional network and calculate the small-world properties (γ, λ, σ, Eglob, and Eloc). Relationships between these small-world properties and clinical and neuropsychological assessments were investigated in OSA patients.ResultsThe networks of both OSA patients and GSs exhibited efficient small-world topology over the sparsity range of 0.05–0.40. Compared with GSs, the OSA group had significantly decreased γ, but significantly increased λ and σ. The OSA group’s brain network showed significantly decreased Eglob (P<0.05) over the sparsity range of 0.09–0.15, but significantly increased Eloc over the sparsity range of 0.23–0.40. In OSA patients, γ was significantly negatively correlated with apnea–hypopnea index (AHI; r=−0.326, P=0.015) and Epworth Sleepiness Scale (ESS; r=−0.274, P=0.043), λ was significantly positively correlated with AHI (r=0.373, P=0.005) and ESS (r=0.269, P=0.047), and σ was significantly negatively correlated with AHI (r=−0.363, P=0.007) and ESS (r=−0.295, P=0.029).ConclusionOur results suggest that the high degree of local integration and integrity of the brain connections in OSA patients may be disrupted. The topological alterations of small-world properties may be the mechanism of cognitive impairment in OSA patients. In addition, σ, γ, and λ could be used as a quantitative physiological index for auxiliary clinical diagnoses.

show abstract

“…Recently, ReHo has been successfully used to explore functional modulations and to characterize pathophysiological changes in patients with sleep problems, such as obstructive sleep apnea 25 and sleep deprivation, 24 and various neuropsychiatric disorders related to mood/emotional changes, such as unhappy individuals, 26 social anxiety disorders, 27 panic disorder, 28 early life stress 29 and depression. 30 However, it has not yet been used to explore pathophysiological changes in PCPIs.…”

Section: Introductionmentioning

confidence: 99%

Altered intrinsic regional brain spontaneous activity and subjective sleep quality in patients with chronic primary insomnia: a resting-state fMRI study

Dai¹,

Peng²,

Gong³

et al. 2014

NDT

Self Cite

107

121

View full text Add to dashboard Cite

Study objectiveTo prospectively explore the underlying regional homogeneity (ReHo) brain-activity deficit in patients with chronic primary insomnia (PCPIs) and its relationship with clinical features.DesignThe ReHo method and Statistical Parametric Mapping 8 software were used to evaluate whether resting-state localized brain activity was modulated between PCPIs and good sleepers (GSs), and correlation analysis between altered regional brain areas and clinical features was calculated.Patients and participantsTwenty-four PCPIs (17 females, seven males) and 24 (12 females, 12 males) age-, sex-, and education-matched GSs.Measurements and resultsPCPIs disturbed subjective sleep quality, split positive mood, and exacerbated negative moods. Compared with GSs, PCPIs showed higher ReHo in left fusiform gyrus, and lower ReHo in bilateral cingulate gyrus and right cerebellum anterior lobe. Compared with female GSs, female PCPIs showed higher ReHo in the left fusiform gyrus and right posterior cingulate, and lower ReHo in the left cerebellum anterior lobe and left superior frontal gyrus. Compared with male GSs, male PCPIs showed higher ReHo in the right temporal lobe and lower ReHo in the bilateral frontal lobe. The fusiform gyrus showed strong positive correlations and the frontal lobe showed negative correlations with the clinical measurements.ConclusionThe ReHo analysis is a useful noninvasive imaging tool for the detection of cerebral changes and the indexing of clinical features. The abnormal spontaneous activity areas provided important information on the neural mechanisms underlying emotion and sleep-quality impairment in PCPIs.

show abstract

Altered intrinsic regional brain activity in male patients with severe obstructive sleep apnea: a resting-state functional magnetic resonance imaging study

Cited by 67 publications

References 45 publications

Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults

Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults

Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI

Altered intrinsic regional brain spontaneous activity and subjective sleep quality in patients with chronic primary insomnia: a resting-state fMRI study

Contact Info

Product

Resources

About